DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31381 and Trit1

DIOPT Version :9

Sequence 1:	NP_001189283.1	Gene:	CG31381 / 192528	FlyBaseID:	FBgn0043799	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	XP_038966235.1	Gene:	Trit1 / 362586	RGDID:	1304781	Length:	488	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	186/494 - (37%)
Similarity:	279/494 - (56%)	Gaps:	63/494 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RKVPLIVVLGSTGTGKTKLSLQLAERFGGEIISADSMQ---------------------VYTHLD 46
            |.:||:|:||:|||||:.|:|||.:|.||||:||||||                     ||..||
  Rat    21 RTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQELSIQCRLALNLWSSASASPMVYEGLD 85

  Fly    47 IATAKATKEEQSRARHHLLDVATP-AEPFTVTHFRNAALPIVERLLAKDTSPIVVGGTNYYIESL 110
            |.|.|.:.:||...|||::....| ...:||..|||.|..::|.:.|:|..||||||||||||||
  Rat    86 IITNKVSAQEQKMCRHHMISFVDPLVTSYTVVDFRNRATALIEDIFARDKIPIVVGGTNYYIESL 150

  Fly   111 LWDILVDSDVKPDEGKHSGEHL-KDAELNALSTLELHQHLAKIDAGSANRIHPNNRRKIIRAIEV 174
            ||.:||.:  || :|..:|:.: :..||......|||:.|:::|...|.::||:::||:.|:::|
  Rat   151 LWKVLVTT--KP-QGMGTGKAVDRKVELEKEDGHELHKRLSQVDPEMAAKLHPHDKRKVARSLQV 212

  Fly   175 YQSTGQTLSQMLAEQRAQPGGNRLGGPLRYPHIVLLWLRCQQDVLNERLDSRVDGMLAQGLLPEL 239
            ::.||.:.|:.|..|.|:.||..|||||::|:..:|||...|.||:||||.|||.|||.|||.||
  Rat   213 FEETGVSHSEFLHRQHAEEGGGPLGGPLKFPNPCILWLHADQAVLDERLDKRVDDMLAAGLLEEL 277

  Fly   240 RQFHNAHHATTV----QAYTSGVLQTIGYKEFIPYLIKYDQQQDEKIEEYLKTHSYKLPGPEKLK 300
            |.||..::...|    |.|..|:.|:||:|||               .|||.|.....|....
  Rat   278 RDFHRRYNLKNVSEDSQDYQHGIFQSIGFKEF---------------HEYLTTEGKCTPETSN-- 325

  Fly   301 EEGLPDGLELLRNCCEELKLVTRRYSKKQLKWINNRFLASKDRQVPDLYELDTSDVSAWQVAVYK 365
                    :||:...|.||.||:||::||.:|:.||||:.....||.:|.|:.||||.|:..|.:
  Rat   326 --------QLLKKGVEALKQVTKRYARKQNRWVRNRFLSRPGPSVPPVYGLEVSDVSKWEEFVLE 382

  Fly   366 RAETIIESYRNEEACEILPMAKREHPGADLDEETS-HFCQICERHFVGEYQWGLHMKSNKHKRRK 429
            .|.:|::|:.........|:   :.|.::.:.:.| |.|.:|:|..:|:.:|..|.||..|..:.
  Rat   383 PALSIVQSFIQGSKPTATPV---KIPYSETENKRSYHMCDLCDRIIIGDREWAAHTKSKSHLHQL 444

  Fly   430 EGQRKRQRDHETMLSTDL----AKKQKEEKEEAGKAETQ 464
            :.:||...|..:.|.:..    ::.:::|.|.:|:.:.:
  Rat   445 KKRRKLDLDAVSALGSQSNSPDSELERKEGESSGQRDQE 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31381	NP_001189283.1	PLN02748	1..446	CDD:215399	183/470 (39%)
		miaA	4..337	CDD:234626	149/359 (42%)
		zf-C2H2_jaz	401..426	CDD:288983	9/24 (38%)
Trit1	XP_038966235.1	NK	17..>55	CDD:418433	21/33 (64%)
		IPPT	80..354	CDD:396328	124/301 (41%)
		zf-C2H2_jaz	416..440	CDD:403410	9/23 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354298
Domainoid	1	1.000	202	1.000	Domainoid score	I2905
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7010
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2509
OMA	1	1.010	-	-		QHG54912
OrthoDB	1	1.010	-	-		D1003231at2759
OrthoFinder	1	1.000	-	-		FOG0003361
OrthoInspector	1	1.000	-	-		oto96093
orthoMCL	1	0.900	-	-		OOG6_100923
Panther	1	1.100	-	-	LDO	PTHR11088
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1130
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910