DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12084 and ZYG11B

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_078922.1	Gene:	ZYG11B / 79699	HGNCID:	25820	Length:	744	Species:	Homo sapiens

Alignment Length:	816	Identity:	215/816 - (26%)
Similarity:	361/816 - (44%)	Gaps:	142/816 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MEDGSLDEEPLTLKEIAYQKLCNNLDIISSHRPDGQRGLNPGIVLPNEICDGFLENYQRFNRPLD 72
            ||:.|    |.:|.:|....|..:|:...|.|.||...|....|.|.|:.|..|.. ..|:..|:
Human    10 MEEAS----PYSLLDICLNFLTTHLEKFCSARQDGTLCLQEPGVFPQEVADRLLRT-MAFHGLLN 69

  Fly    73 DSVIRLFEDTHRTSLKIVNLRNSTLSSIGL-ETLMRHKLFAL-------SLWYCDMISVGSHHLL 129
            |..:.:|.. ::..||...:|.:.:|::.. :....|||..|       .:...|:||
Human    70 DGTVGIFRG-NQMRLKRACIRKAKISAVAFRKAFCHHKLVELDATGVNADITITDIIS------- 126

  Fly   130 AHYGDSLRSLELGISSHLLQYAEPNEKEPVDFQLTCPHLRRLVLNGVVMH----HRLQFAHLHDL 190
                        |:.|:  ::.:.|        |.|     ||||.:.:.    :...|:.|..|
Human   127 ------------GLGSN--KWIQQN--------LQC-----LVLNSLTLSLEDPYERCFSRLSGL 164

  Fly   191 GHLDLTSCVLANFSLEALGSLPNLHTLILFNVWPIANQLHAICCLRRLCTLDISISSSGNGHGTY 255
            ..|.:|:.:..|..|..:.|||.|.:|.:.|. .|.:....:.|..||.:|.:        |...
Human   165 RALSITNVLFYNEDLAEVASLPRLESLDISNT-SITDITALLACKDRLKSLTM--------HHLK 220

  Fly   256 DLPDQTLEML--MDNLRHLTHLDISGTNLAGNGVATK-----------ESTTTSGMQQSPKMEQH 307
            .|...|.::|  :..|:||.|||||......:.:|.:           .|...||.:.
Human   221 CLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKH------- 278

  Fly   308 FALTDIPGLASRTQRP-LQFLGLYHT-----------AHWACKRHDIPALEVAGDANEQQILTAA 360
              :||....|...||| :||:||..|           .|          |:|:|:|||.||..|.
Human   279 --VTDKAVEAFIQQRPSMQFVGLLATDAGYSEFLTGEGH----------LKVSGEANETQIAEAL 331

  Fly   361 RYYHDRPVLLTRVLNDLYHLFRFENC--KDIHTALDVVLSAMDRHLKFKHMQISGSATLFYIVKG 423
            :.|.:|...   |...|:|||...:.  |.....|.:|::.|..|.....:|::.||.:|.:.|.
Human   332 KRYSERAFF---VREALFHLFSLTHVMEKTKPEILKLVVTGMRNHPMNLPVQLAASACVFNLTKQ 393

  Fly   424 RDRSKFGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILLHGVSK 488
            ...:.....|...:...||..||.......:.:|..|:|....:..||.|......|:::..:..
Human   394 DLAAGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCN 458

  Fly   489 TEQEGFVQRIAIYLLNTLACQVDGRQKLFLG-ELGVVSTMFTLIKDRLTRSVFDDVMEVAWSTMW 552
            .|.:. :||:|:.:::.||.::...|...|| ||.:|..:..::|.:..::..|..::...|.:|
Human   459 HEDQN-MQRMAVAIISILAAKLSTEQTAQLGTELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALW 522

  Fly   553 NVTDETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVF 617
            |:|||:...|:.|::.:|:|.|::.|.:||....:.:.::|||.|:|||:.|..:||.::||:..
Human   523 NLTDESPTTCRHFIENQGLELFMRVLESFPTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHI 587

  Fly   618 ARLLDSLSDGIEVGGASASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIKTP 682
            :.||.|    :||                          :|||.|||::||:.|.|..|||:...
Human   588 SSLLHS----VEV--------------------------EVSYFAAGIIAHLISRGEQAWTLSRS 622

  Fly   683 SREHVLERMVAAIQRWNIKSERNINYRSFEPILSLVRCYETPQCQHWAVWALANLTQVYPEKYCK 747
            .|..:|:.:.:||.:|.......:.||||.|...|:.|:.||..|.|||||:.::....|.:||.
Human   623 QRNSLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSRYCS 687

  Fly   748 LVEQENGIQILNELIEHESPYCEIKRIARLVIEQCD 783
            ::.:|.|:|.|..:.:||.....:::||..:::..:
Human   688 MLIEEGGLQHLYNIKDHEHTDPHVQQIAVAILDSLE 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	5/31 (16%)
		leucine-rich repeat	136..167	CDD:275381	5/30 (17%)
		leucine-rich repeat	168..189	CDD:275381	6/24 (25%)
		leucine-rich repeat	190..213	CDD:275381	7/22 (32%)
		ARM	535..628	CDD:237987	30/92 (33%)
ZYG11B	NP_078922.1	leucine-rich repeat	107..136	CDD:275381	7/49 (14%)
		leucine-rich repeat	138..163	CDD:275381	8/29 (28%)
		inl_like_NEAT_1	<143..>248	CDD:411101	32/113 (28%)
		leucine-rich repeat	164..182	CDD:275381	5/17 (29%)
		LRR 1	185..208		6/23 (26%)
		leucine-rich repeat	188..213	CDD:275381	7/25 (28%)
		leucine-rich repeat	214..238	CDD:275381	6/31 (19%)
		LRR 2	216..236		4/27 (15%)
		LRR 3	237..261		8/23 (35%)
		leucine-rich repeat	239..267	CDD:275381	7/27 (26%)
		leucine-rich repeat	268..293	CDD:275381	8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820