DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12084 and zyg11l

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_695816.5	Gene:	zyg11l / 567429	ZFINID:	ZDB-GENE-030131-5941	Length:	732	Species:	Danio rerio

Alignment Length:	816	Identity:	205/816 - (25%)
Similarity:	350/816 - (42%)	Gaps:	148/816 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LDEE-PLTLKEIAYQKLCNNLDIISSHRPDGQRGLNPGIVLPNEICDGFLENYQRFNRPLDDSVI 76
            :||| |.:|.:|:...:|:|::.:...:.:|....:...|.|.|:.|..|.. ......|:|..:
Zfish     1 MDEESPPSLTDISLMWICHNVEELCVAQENGSLKFHHCPVFPQELADQLLHK-MASEGVLNDRTV 64

  Fly    77 RLFEDTHRTSLKIVNLRNSTLSSIGLE-TLMRHKLFALSLWYCDMISVGSH-----------HLL 129
            .:|:......|:..::::|.:|:.... .|..|||..|.:         ||           |.|
Zfish    65 GIFQHLEHLRLRRAHIQSSHISAEAFRLALCIHKLQELDI---------SHTQTNIAISEVLHSL 120

  Fly   130 AHYGDSLRSLELGISSHLLQYAEPNEKEPVDFQLTCPHLRRLVLNGVVMHHRLQFAHLHDLGHLD 194
            .......:||:..:...|..|.:.||                         .:.|:.|..|..|.
Zfish   121 TSSKLCRQSLQTLLMDGLRVYGDTNE-------------------------NVSFSMLRGLKKLS 160

  Fly   195 LTSCVLANFSLEALGSLPNLHTL-----ILFNVWPIANQLHAICCLRRLCTLDISISSSGNGHGT 254
            |....|.:.|||.:.:||.|..|     .:.::.|:.|      |..:|.:|.:        ||.
Zfish   161 LAGTDLNDSSLEDICTLPMLENLDISSTNITDLTPLLN------CQSQLKSLTL--------HGL 211

  Fly   255 YDLPDQTLEM-------LMDNLRHLTHLDISGTNLAGNGVATKESTTTSGMQQSPKMEQHFALTD 312
                 |.|||       ::..|..|.|||||...|     .|........:.:.|.:..:....|
Zfish   212 -----QKLEMNASRVNLVLSKLELLRHLDISNDKL-----LTDVDHLVQQLLEQPGILLNLVSLD 266

  Fly   313 IPG------LASRT---QRP-LQFLGLYHTAHWACK--RHDIPALEVAGDANEQQILTAARYYHD 365
            :.|      .|.|.   .|| ::|:||..|.....:  |.| ..|:|||:||.||:..|.|.|.:
Zfish   267 VSGWRGVSDAAIRAFVEHRPGMRFIGLLATGAGGSEMLRGD-GNLKVAGEANLQQLCEALRRYSE 330

  Fly   366 RPVLLTRVLNDLY-HLFRFENCKDIHTALDVVLSAMDRHLKFKHMQISGSATLF-----YIVKGR 424
            |...:...|..|| |....|..:.  ..|.:||:.|.||....|:|:..||.:|     .:|.|.
Zfish   331 RESFIRETLAHLYSHTSELEEPQP--NILKLVLAGMRRHTDSLHVQLVASACVFNLTVQELVLGM 393

  Fly   425 DRSKFGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTLTQFH----MPVDVLFEYERLIKILLHG 485
            .....|.     :::.||..|:.....:.:.:|..|||...|    :|.| .:|..:||.:||
Zfish   394 PLHLLGT-----VVKQLLIAMKNFPKHEQLQKNCLLTLCSDHILQVVPFD-RYEAAKLIMMLL-- 450

  Fly   486 VSKTEQEGFVQRIAIYLLNTLACQVDGRQKLFLG-ELGVVSTMFTLIKDRLTRSVFDDVMEVAWS 549
              ...::..|||:.:.:::.|..::...:...|| |..::..:.::::.:.:..:.|..::.|.|
Zfish   451 --GNHEDQTVQRMVVAVVSILVSKLSTEEISKLGAEEFIMKQLLSIVQQKASLGLVDSTLKFALS 513

  Fly   550 TMWNVTDETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFI 614
            .:||:||||...|..|:..||:|.:|:.|.|:.....:.:.::|||.|||||:.|||:||.:|.:
Zfish   514 ALWNLTDETPTACTHFIQCRGVELYLELLETYYSESSIQQKLLGLLNNVAEVEDLRPELMNEELL 578

  Fly   615 EVFARLLDSLSDGIEVGGASASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTI 679
            |...:||  :...:||                          .|||.|.|:|||:.|.....|::
Zfish   579 EHILQLL--VLPLVEV--------------------------DVSYFAGGILAHLVSVRGPVWSL 615

  Fly   680 KTPSREHVLERMVAAIQRWNIKSERNINYRSFEPILSLVRCYETPQCQHWAVWALANLTQVYPEK 744
            ....|..|.:::.::|..|:......::||:|:|...|:...::...|.||:||:..|......:
Zfish   616 DEELRCTVQDQLHSSILSWSSPQHVMVSYRTFQPFFPLLDVCQSSGVQLWALWAIQFLCSQNAPQ 680

  Fly   745 YCKLVEQENGIQILNELIEHESPYCEIKRIARLVIE 780
            ||.::|.|.|..:|..||.|...:.::|.:...:::
Zfish   681 YCSMLESEGGTDLLRVLIHHAETHSDVKSLVESILK 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	6/35 (17%)
		leucine-rich repeat	136..167	CDD:275381	6/30 (20%)
		leucine-rich repeat	168..189	CDD:275381	2/20 (10%)
		leucine-rich repeat	190..213	CDD:275381	8/22 (36%)
		ARM	535..628	CDD:237987	34/92 (37%)
zyg11l	XP_695816.5	LRR_RI	<70..257	CDD:238064	51/244 (21%)
		leucine-rich repeat	70..98	CDD:275381	4/27 (15%)
		LRR	98..>269	CDD:227223	48/228 (21%)
		leucine-rich repeat	99..128	CDD:275381	6/37 (16%)
		leucine-rich repeat	130..155	CDD:275381	7/49 (14%)
		leucine-rich repeat	156..179	CDD:275381	8/22 (36%)
		leucine-rich repeat	180..202	CDD:275381	5/27 (19%)
		leucine-rich repeat	203..230	CDD:275381	9/39 (23%)
		leucine-rich repeat	231..261	CDD:275381	9/34 (26%)
		leucine-rich repeat	262..284	CDD:275381	4/21 (19%)
		ARM	505..607	CDD:237987	44/129 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920