DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12084 and zyg11

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001035422.1	Gene:	zyg11 / 555349	ZFINID:	ZDB-GENE-041014-17	Length:	746	Species:	Danio rerio

Alignment Length:	810	Identity:	212/810 - (26%)
Similarity:	355/810 - (43%)	Gaps:	137/810 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SLDEEPL-TLKEIAYQKLCNNLDIISSHRPDGQRGLNPGIVLPNEICDGFLENYQRFNRPLDDSV 75
            ::|:..| :|.::....:.:.|::....|.||.......:|.|.|:.|..|.. ...:..|:||.
Zfish     7 TMDKSSLPSLSDLCMSLVSSRLELFCEMRDDGSLSFREPLVFPQELADQLLCK-MATDGVLNDST 70

  Fly    76 IRLFEDTHRTSLKIVNLRNSTLSSIGL-ETLMRHKLFALSLWYCDMISVGSHHLLAHYGDSLRSL 139
            :.:|.:..:..|:...:|.:.:|:... ..|..|:|..|     |...|.:...:|   |.||.|
Zfish    71 VGIFRNCQQFRLRHACIRTARISAEAFHRALCPHRLVEL-----DASRVNADLTIA---DILRGL 127

  Fly   140 ELGISSHLLQYAEPNEKEPVDFQLTCPHLRRLVLNGVVMHHRLQFAHLHDLGHLDLTSCVLANFS 204
            .   |:..||.:                |:||||||                   ||...|...|
Zfish   128 S---SNKSLQES----------------LQRLVLNG-------------------LTMSSLEEPS 154

  Fly   205 LEALGSLPNLHTLILFNV----WPIANQLHAICCLRRLCTLDISISSSGN--------------- 250
            .....::..|..|.:.||    |.:|:    :|.|.||.:||||.:|..|
Zfish   155 RRCFSAMQGLRALSVSNVDFYDWGLAD----VCLLPRLESLDISNTSVSNLTPLLGLRSRLRYLT 215

  Fly   251 GHGTYDLPDQTLEML--MDNLRHLTHLDISGTNLAGNGVATK-----------ESTTTSGMQQSP 302
            .|....|...|.::|  :..|..|.|||||......:.||.:           .|...||.:|
Zfish   216 MHQLKRLEMTTAQLLAVLSQLEVLQHLDISDDKQFTSDVARQLLETPGILPQLVSLDVSGRKQ-- 278

  Fly   303 KMEQHFALTDIPGLASRTQRP-LQFLGLYHT-AHWACKRHDIPALEVAGDANEQQILTAARYYHD 365
                   :||....|....|| :.|:||..| |.::.......:|:|.|:|||.||..|.|.|.:
Zfish   279 -------VTDAAVKAFVEARPGMTFVGLLATDAGFSEFLSGEGSLKVTGEANETQICEALRRYSE 336

  Fly   366 RPVLLTRVLNDLYHLFRFENC--KDIHTALDVVLSAMDRHLKFKHMQISGSATLFYIVKGRDRSK 428
            |...   |...|:|||...:.  |.....|.:|...|..|....::|::.||.:|.:.|  ....
Zfish   337 REGF---VREALFHLFSLTHAIEKPRPDILKLVALGMKNHPTTLNVQLAASACVFNLTK--QELA 396

  Fly   429 FGALLR--NHIIRTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILLHGVSKTEQ 491
            ||..:|  .::.:.||..|:.......:.:|..|:|....:..:|.|......|:::..:...|.
Zfish   397 FGIPVRLLGNVTQQLLEAMKTFPNHQQLQKNCLLSLCSDRILQEVPFNRFEAAKLVMQWLCNHED 461

  Fly   492 EGFVQRIAIYLLNTLACQVDGRQKLFLG-ELGVVSTMFTLIKDRLTRSVFDDVMEVAWSTMWNVT 555
            :. :||:|:.:::.||.::...|...|| ||.:|..:..:::.:..:|..|..::...|.:||:|
Zfish   462 QN-MQRMAVAIISILAAKLSTEQTAQLGAELFIVKQLLHIVRQKTCQSTVDATLKFTLSALWNLT 525

  Fly   556 DETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVFARL 620
            ||:...|:.|::.:|:|.|:|.|.:||....:.:.::|||.|:|||..|..:||.|.|::....|
Zfish   526 DESPTTCRHFIENQGLELFIKVLESFPSESSIQQKVLGLLNNIAEVSELHGELMVQSFLDHIRTL 590

  Fly   621 LDSLSDGIEVGGASASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIKTPSRE 685
            |.|    .||                          :|||.|||:|||:.|.|...||::...|.
Zfish   591 LHS----PEV--------------------------EVSYFAAGILAHLTSRGEKVWTLELTLRN 625

  Fly   686 HVLERMVAAIQRWNIKSERNINYRSFEPILSLVRCYETPQCQHWAVWALANLTQVYPEKYCKLVE 750
            .:|:::.:||.:|.......:.||||.|...|:.|::||..|.||.||:.::......:||.::.
Zfish   626 TLLQQLHSAILKWPTPECEMVAYRSFNPFFPLLECFQTPGVQLWAAWAMQHVCSKNAGRYCSMLL 690

  Fly   751 QENGIQILNELIEHESPYCEIKRIARLVIE 780
            :|.|:|.|..:..|...:.:::|:...:::
Zfish   691 EEGGLQHLEAITSHPKTHSDVRRLTESILD 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	5/24 (21%)
		leucine-rich repeat	136..167	CDD:275381	6/30 (20%)
		leucine-rich repeat	168..189	CDD:275381	7/20 (35%)
		leucine-rich repeat	190..213	CDD:275381	4/22 (18%)
		ARM	535..628	CDD:237987	32/92 (35%)
zyg11	NP_001035422.1	leucine-rich repeat	77..105	CDD:275381	4/27 (15%)
		leucine-rich repeat	106..129	CDD:275381	9/33 (27%)
		leucine-rich repeat	137..163	CDD:275381	11/44 (25%)
		leucine-rich repeat	164..187	CDD:275381	8/26 (31%)
		LRR 1	185..209		9/23 (39%)
		leucine-rich repeat	188..210	CDD:275381	7/21 (33%)
		leucine-rich repeat	211..236	CDD:275381	4/24 (17%)
		LRR 2	216..241		6/24 (25%)
		leucine-rich repeat	239..267	CDD:275381	8/27 (30%)
		LRR 3	265..289		7/32 (22%)
		leucine-rich repeat	268..290	CDD:275381	7/30 (23%)
		ARM	504..611	CDD:237987	43/136 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820