DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12084 and ZYG11A

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001004339.2	Gene:	ZYG11A / 440590	HGNCID:	32058	Length:	759	Species:	Homo sapiens

Alignment Length:	818	Identity:	205/818 - (25%)
Similarity:	349/818 - (42%)	Gaps:	139/818 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSCKVRLMEDGSLDEEPLTLKEIAYQKLCNNLDIISSHRPDGQRGLNPGIVLPNEICDGFLENYQ 65
            :.|.| :.|:.|    |.||..|....|..||:.:.|.||||...|......|.|:.:.|| ...
Human    24 LGCCV-VQEEAS----PYTLVNICLNVLIANLEKLCSERPDGTLCLPEHWSFPQEVAERFL-RVM 82

  Fly    66 RFNRPLDDSVIRLFEDTHRTSLKIVNLRNSTLSSIG-LETLMRHKLFALS-------LWYCDMIS 122
            .:...|.|....:|.. ::..||:||::.:.:|:.. ::...||||..|:       |...|:||
Human    83 TWQGKLTDRTASIFRG-NQMKLKLVNIQKAKISTAAFIKAFCRHKLIELNATAVHADLPVPDIIS 146

  Fly   123 VGSHHLLAHYGDSLRSLELGISSHLLQYAEPNEKEPVDFQLTCPHLRRLVLN--GVVMHHRLQ-F 184
                               |:.|:  ::.:.|        |.|     |:|:  .:..:.||. |
Human   147 -------------------GLCSN--RWIQQN--------LQC-----LLLDSTSIPQNSRLLFF 177

  Fly   185 AHLHDLGHLDLTSCVLANFSLEALGSLPNLHTLILFNVWPIANQLHA-ICCLRRLCTLD------ 242
            :.|..|..|.:.:.......|..:..||.|.:|.:.|.  :...:.| :.|..||.:|.
Human   178 SQLTGLRILSVFNVCFHTEDLANVSQLPRLESLDISNT--LVTDISALLTCKDRLKSLTMHYLKC 240

  Fly   243 ISISSSGNGHGTYDLPDQTLEMLMDNLRHLTHLDISGTNLAGNGVATKESTTTSGMQQSPKMEQH 307
            ::::.|           |.|.::.: |:.|.|||||...      ..|.......:||...:...
Human   241 LAMTKS-----------QILAVIRE-LKCLLHLDISDHR------QLKSDLAFHLLQQKDILPNV 287

  Fly   308 FALTDIPG----------LASRTQRPLQFLGLYHT-----AHWACKRHDIPALEVAGDANEQQIL 357
            .:| ||.|          |..|.:..:||:||..|     ..:..|:    .|.|||.|:..||.
Human   288 VSL-DISGGNCITDEAVELFIRLRPAMQFVGLLATDAGSSDFFTTKQ----GLRVAGGASMSQIS 347

  Fly   358 TAARYYHDRPVLLTRVLNDLY-HLFRFENCKDIHTALDVVLSAMDRHLKFKHMQISGSATLFYIV 421
            .|...|.:|...:...|:.|: ..|..|  ..:...|.:|...|..|.....:|.:.||....:.
Human   348 EALSRYRNRSCFVKEALHRLFTETFSME--VTMPAILKLVAIGMRNHPLDLRVQFTASACALNLT 410

  Fly   422 KGRDRSKFGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILLHGV 486
            :..........|.:.:...|...::.......:.:|..|:||...:.|||.|:.....|.::..:
Human   411 RQGLAKGMPVRLLSEVTCLLFKALKNFPHYQQLQKNCLLSLTNSRILVDVPFDRFDAAKFVMRWL 475

  Fly   487 SKTEQEGFVQRIAIYLLNTLACQVDGRQKLFLGELGV-VSTMFTLIKDRLTRSVFDDVMEVAWST 550
            .|.|... :|.:|:.:.:.||.|:...|...|.||.: |..:..::|.:.|.::.|.........
Human   476 CKHENPK-MQTMAVSVTSILALQLSPEQTAQLEELFMAVKELLAIVKQKTTENLDDVTFLFTLKA 539

  Fly   551 MWNVTDETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIE 615
            :||:||.:...||.|::.:|::.|::.|.||.: ..:...::|||.|:|||:.|..||:|::.::
Human   540 LWNLTDGSPAACKHFIENQGLQIFIQVLETFSE-SAIQSKVLGLLNNIAEVRELSSKLVTEDVLK 603

  Fly   616 VFARLLDSLSDGIEVGGASASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIK 680
            ....||.|                    |||          :|||.|||::||:.|| ...|..:
Human   604 HINSLLCS--------------------REM----------EVSYFAAGIIAHLTSD-RQLWISR 637

  Fly   681 TPSREHVLERMVAAIQRW---NIKSERNINYRSFEPILSLVRCYETPQCQHWAVWALANLTQVYP 742
            ...|..:|:.:.|.||.|   :.|....:.||||:....|:..:..|:.|.||:||:.::....|
Human   638 DFQRRTLLQDLHATIQNWPSSSCKMTALVTYRSFKTFFPLLGNFSQPEVQLWALWAMYHVCSKNP 702

  Fly   743 EKYCKLVEQENGIQILNELIEHESPYCEIKRIARLVIE 780
            .||||::.:|.|:|:|.::.||.....:.::||..:::
Human   703 SKYCKMLVEEEGLQLLCDIQEHSEATPKAQQIAASILD 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	6/31 (19%)
		leucine-rich repeat	136..167	CDD:275381	5/30 (17%)
		leucine-rich repeat	168..189	CDD:275381	6/23 (26%)
		leucine-rich repeat	190..213	CDD:275381	4/22 (18%)
		ARM	535..628	CDD:237987	28/92 (30%)
ZYG11A	NP_001004339.2	leucine-rich repeat	158..182	CDD:275381	8/28 (29%)
		leucine-rich repeat	183..206	CDD:275381	4/22 (18%)
		LRR_RI	<195..314	CDD:238064	30/139 (22%)
		LRR 1	204..227		6/24 (25%)
		leucine-rich repeat	207..229	CDD:275381	5/23 (22%)
		leucine-rich repeat	230..257	CDD:275381	6/38 (16%)
		LRR 2	235..260		5/36 (14%)
		leucine-rich repeat	258..286	CDD:275381	9/33 (27%)
		leucine-rich repeat	287..312	CDD:275381	6/25 (24%)
		LRR 3	490..513		7/22 (32%)
		ARM	511..629	CDD:237987	41/148 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820