Protein Alignment CG12084 and ZYG11A

DIOPT Version :10

• Sequence 1: NP_612112.1
• Gene: CG12084 / 192509
• FlyBaseID: FBgn0043458
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_001004339.2
• Gene: ZYG11A / 440590
• HGNCID: 32058
• Length: 759
• Species: Homo sapiens
• Alignment Length: 818
• Identity: 205/818 - (25%)
• Similarity: 349/818 - (42%)
• Gaps: 139/818 - (16%)

  Fly     1 MSCKVRLMEDGSLDEEPLTLKEIAYQKLCNNLDIISSHRPDGQRGLNPGIVLPNEICDGFLENYQ 65
            :.|.| :.|:.|    |.||..|....|..||:.:.|.||||...|......|.|:.:.|| ...
Human    24 LGCCV-VQEEAS----PYTLVNICLNVLIANLEKLCSERPDGTLCLPEHWSFPQEVAERFL-RVM 82

  Fly    66 RFNRPLDDSVIRLFEDTHRTSLKIVNLRNSTLSSIG-LETLMRHKLFALS-------LWYCDMIS 122
            .:...|.|....:|.. ::..||:||::.:.:|:.. ::...||||..|:       |...|:||
Human    83 TWQGKLTDRTASIFRG-NQMKLKLVNIQKAKISTAAFIKAFCRHKLIELNATAVHADLPVPDIIS 146

  Fly   123 VGSHHLLAHYGDSLRSLELGISSHLLQYAEPNEKEPVDFQLTCPHLRRLVLN--GVVMHHRLQ-F 184
                               |:.|:  ::.:.|        |.|     |:|:  .:..:.||. |
Human   147 -------------------GLCSN--RWIQQN--------LQC-----LLLDSTSIPQNSRLLFF 177

  Fly   185 AHLHDLGHLDLTSCVLANFSLEALGSLPNLHTLILFNVWPIANQLHA-ICCLRRLCTLD------ 242
            :.|..|..|.:.:.......|..:..||.|.:|.:.|.  :...:.| :.|..||.:|.
Human   178 SQLTGLRILSVFNVCFHTEDLANVSQLPRLESLDISNT--LVTDISALLTCKDRLKSLTMHYLKC 240

  Fly   243 ISISSSGNGHGTYDLPDQTLEMLMDNLRHLTHLDISGTNLAGNGVATKESTTTSGMQQSPKMEQH 307
            ::::.|           |.|.::.: |:.|.|||||...      ..|.......:||...:...
Human   241 LAMTKS-----------QILAVIRE-LKCLLHLDISDHR------QLKSDLAFHLLQQKDILPNV 287

  Fly   308 FALTDIPG----------LASRTQRPLQFLGLYHT-----AHWACKRHDIPALEVAGDANEQQIL 357
            .:| ||.|          |..|.:..:||:||..|     ..:..|:    .|.|||.|:..||.
Human   288 VSL-DISGGNCITDEAVELFIRLRPAMQFVGLLATDAGSSDFFTTKQ----GLRVAGGASMSQIS 347

  Fly   358 TAARYYHDRPVLLTRVLNDLY-HLFRFENCKDIHTALDVVLSAMDRHLKFKHMQISGSATLFYIV 421
            .|...|.:|...:...|:.|: ..|..|  ..:...|.:|...|..|.....:|.:.||....:.
Human   348 EALSRYRNRSCFVKEALHRLFTETFSME--VTMPAILKLVAIGMRNHPLDLRVQFTASACALNLT 410

  Fly   422 KGRDRSKFGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILLHGV 486
            :..........|.:.:...|...::.......:.:|..|:||...:.|||.|:.....|.::..:
Human   411 RQGLAKGMPVRLLSEVTCLLFKALKNFPHYQQLQKNCLLSLTNSRILVDVPFDRFDAAKFVMRWL 475

  Fly   487 SKTEQEGFVQRIAIYLLNTLACQVDGRQKLFLGELGV-VSTMFTLIKDRLTRSVFDDVMEVAWST 550
            .|.|... :|.:|:.:.:.||.|:...|...|.||.: |..:..::|.:.|.::.|.........
Human   476 CKHENPK-MQTMAVSVTSILALQLSPEQTAQLEELFMAVKELLAIVKQKTTENLDDVTFLFTLKA 539

  Fly   551 MWNVTDETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIE 615
            :||:||.:...||.|::.:|::.|::.|.||.: ..:...::|||.|:|||:.|..||:|::.::
Human   540 LWNLTDGSPAACKHFIENQGLQIFIQVLETFSE-SAIQSKVLGLLNNIAEVRELSSKLVTEDVLK 603

  Fly   616 VFARLLDSLSDGIEVGGASASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIK 680
            ....||.|                    |||          :|||.|||::||:.|| ...|..:
Human   604 HINSLLCS--------------------REM----------EVSYFAAGIIAHLTSD-RQLWISR 637

  Fly   681 TPSREHVLERMVAAIQRW---NIKSERNINYRSFEPILSLVRCYETPQCQHWAVWALANLTQVYP 742
            ...|..:|:.:.|.||.|   :.|....:.||||:....|:..:..|:.|.||:||:.::....|
Human   638 DFQRRTLLQDLHATIQNWPSSSCKMTALVTYRSFKTFFPLLGNFSQPEVQLWALWAMYHVCSKNP 702

  Fly   743 EKYCKLVEQENGIQILNELIEHESPYCEIKRIARLVIE 780
            .||||::.:|.|:|:|.::.||.....:.::||..:::
Human   703 SKYCKMLVEEEGLQLLCDIQEHSEATPKAQQIAASILD 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	6/31 (19%)
		leucine-rich repeat	136..167	CDD:275381	5/30 (17%)
		leucine-rich repeat	168..189	CDD:275381	6/23 (26%)
		LRR	<184..>282	CDD:443914	25/104 (24%)
		leucine-rich repeat	190..213	CDD:275381	4/22 (18%)
ZYG11A	NP_001004339.2	LRR	<157..331	CDD:443914	46/207 (22%)
		leucine-rich repeat	158..182	CDD:275381	8/28 (29%)
		leucine-rich repeat	183..206	CDD:275381	4/22 (18%)
		LRR 1	204..227		6/24 (25%)
		leucine-rich repeat	207..229	CDD:275381	5/23 (22%)
		leucine-rich repeat	230..257	CDD:275381	6/38 (16%)
		LRR 2	235..260		5/36 (14%)
		leucine-rich repeat	258..286	CDD:275381	9/33 (27%)
		leucine-rich repeat	287..312	CDD:275381	6/25 (24%)
		LRR 3	490..513		7/22 (32%)