DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12084 and Zyg11b

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001028806.2	Gene:	Zyg11b / 414872	MGIID:	2685277	Length:	744	Species:	Mus musculus

Alignment Length:	815	Identity:	225/815 - (27%)
Similarity:	369/815 - (45%)	Gaps:	140/815 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MEDGSLDEEPLTLKEIAYQKLCNNLDIISSHRPDGQRGLNPGIVLPNEICDGFLENYQRFNRPLD 72
            ||:.|    |.:|.:|....|..||:...|.|.||...|....|.|.|:.|..|:.. .|:..|:
Mouse    10 MEEAS----PYSLLDICLSFLTTNLEKFCSARQDGTLCLQEPGVFPQEVADRLLQTI-AFHGLLN 69

  Fly    73 DSVIRLFEDTHRTSLKIVNLRNSTLSSIGL-ETLMRHKLFAL-------SLWYCDMISVGSHHLL 129
            |..:.:|.. ::..||...:|.:.:|::.. :....|||..|       .:...|:||
Mouse    70 DGTVGIFRG-NQMRLKRACIRKAKISAVAFRKAFCHHKLVELDATGVNADITITDIIS------- 126

  Fly   130 AHYGDSLRSLELGISSHLLQYAEPNEKEPVDFQLTCPHLRRLVLNGVVMH----HRLQFAHLHDL 190
                        |:.|:  ::.:.|        |.|     ||||.:.:.    :...|:.|..|
Mouse   127 ------------GLGSN--KWIQQN--------LQC-----LVLNSLTLSLEDPYERCFSRLSGL 164

  Fly   191 GHLDLTSCVLANFSLEALGSLPNLHTLILFNVWPIANQLHAICCLRRLCTLDISISSSGNGHGTY 255
            ..|.:|:.:..|..|..:.|||.|.:|.:.|. .|.:....:.|..||.:|.:        |...
Mouse   165 RALSITNVLFYNEDLAEVASLPRLESLDISNT-SITDITALLACKDRLKSLTM--------HHLK 220

  Fly   256 DLPDQTLEML--MDNLRHLTHLDISGTNLAGNGVATK-----------ESTTTSGMQQSPKMEQH 307
            .|...|.::|  :..|:||.|||||......:.:|.:           .|...||.:.
Mouse   221 CLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKH------- 278

  Fly   308 FALTDIPGLASRTQRP-LQFLGLYHT-AHWA----CKRHDIPALEVAGDANEQQILTAARYYHDR 366
              :||....|...||| :||:||..| |.::    .|.|    |:|:|:|||.||..|.|.|.:|
Mouse   279 --VTDKAVEAFIQQRPSMQFVGLLATDAGYSEFLMGKGH----LKVSGEANETQIAEALRRYSER 337

  Fly   367 PVLLTRVLNDLYHLFR----FENCK-DIHTALDVVLSAMDRHLKFKHMQISGSATLFYIVKGRDR 426
            ...   |...|:|||.    .|..| ||   |.:|::.|..|.....:|::.||.:|.:.|....
Mouse   338 AFF---VREALFHLFSLTHVMEKTKPDI---LKLVVTGMRNHPMNLPVQLAASACVFNLTKQDLA 396

  Fly   427 SKFGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILLHGVSKTEQ 491
            ......|...:...||..||.......:.:|..|:|....:..||.|......|:::..:...|.
Mouse   397 LGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHED 461

  Fly   492 EGFVQRIAIYLLNTLACQVDGRQKLFLG-ELGVVSTMFTLIKDRLTRSVFDDVMEVAWSTMWNVT 555
            :. :||:|:.:::.||.::...|...|| ||.:|..:..::|.:..::..|..::...|.:||:|
Mouse   462 QN-MQRMAVAIISILAAKLSTEQTAQLGAELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNLT 525

  Fly   556 DETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVFARL 620
            ||:...|:.|::.:|:|.|::.|.:||....:.:.::|||.|:|||:.|..:||.::||:..:.|
Mouse   526 DESPTTCRHFIENQGLELFMRVLESFPTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISSL 590

  Fly   621 LDSLSDGIEVGGASASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIKTPSRE 685
            |.|    :||                          :|||.|||::||:.|.|..|||:....|.
Mouse   591 LHS----VEV--------------------------EVSYFAAGIIAHLISRGEQAWTLSRSQRN 625

  Fly   686 HVLERMVAAIQRWNIKSERNINYRSFEPILSLVRCYETPQCQHWAVWALANLTQVYPEKYCKLVE 750
            .:|:.:.:||.:|.......:.||||.|...|:.|:.||..|.|||||:.::....|.:||.::.
Mouse   626 SLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSRYCSMLI 690

  Fly   751 QENGIQILNELIEHE--SPYCEIKRIARLVIEQCD 783
            :|.|:|.|..:.|||  .||  :::||..:::..:
Mouse   691 EEGGLQHLYNIKEHEQTDPY--VQQIAVAILDSLE 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	5/31 (16%)
		leucine-rich repeat	136..167	CDD:275381	5/30 (17%)
		leucine-rich repeat	168..189	CDD:275381	6/24 (25%)
		leucine-rich repeat	190..213	CDD:275381	7/22 (32%)
		ARM	535..628	CDD:237987	30/92 (33%)
Zyg11b	NP_001028806.2	leucine-rich repeat	107..136	CDD:275381	7/49 (14%)
		leucine-rich repeat	138..163	CDD:275381	8/29 (28%)
		leucine-rich repeat	164..182	CDD:275381	5/17 (29%)
		LRR_RI	<177..299	CDD:238064	36/139 (26%)
		LRR 1	185..208		6/23 (26%)
		leucine-rich repeat	188..213	CDD:275381	7/25 (28%)
		leucine-rich repeat	214..238	CDD:275381	6/31 (19%)
		LRR 2	216..236		4/27 (15%)
		LRR 3	237..261		8/23 (35%)
		leucine-rich repeat	239..267	CDD:275381	7/27 (26%)
		leucine-rich repeat	268..293	CDD:275381	8/33 (24%)
		ARM	493..611	CDD:237987	42/147 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820