DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12084 and zer1

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_998066.1	Gene:	zer1 / 405837	ZFINID:	ZDB-GENE-040426-2307	Length:	774	Species:	Danio rerio

Alignment Length:	804	Identity:	291/804 - (36%)
Similarity:	413/804 - (51%)	Gaps:	74/804 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EEPLTLKEIAYQKLCNNLDIISSHRPDGQR-GLNPGIVLPNEICDGFLENY-------QRFNRPL 71
            ::|.:|..:..:....||.....:..:..| .|.|.:.||:||||..:..|       ..|..
Zfish     7 DDPDSLMSLCTEFCLRNLRRTMCYSGERNRLSLRPDVFLPSEICDRLVNAYMDLVHTDSEFEP-- 69

  Fly    72 DDSVIRLFEDTHRTSLKIVNLRNSTLSSIGLETLMRHKLFALSLWYCDMISVGSHHLLAHYGDSL 136
            .|...:||.|...|.|..:.||...|....||.:.:..|..|.|..|..:|..:...|:.:..:|
Zfish    70 QDGFFQLFSDPRSTRLTRLTLREDLLRDRDLEAISKQDLMELHLTDCSRLSSRALRTLSSFRHTL 134

  Fly   137 RSLEL----GI----SSHLLQYAEPNEKE-----------PVDFQLT-CPHLRRLVLNGVVMHHR 181
            .||.|    ||    |...|...|.:|::           .|||... ...||.|.:.|:.....
Zfish   135 LSLSLFGCSGIFFRKSGAPLASGEQDEEDEDPLEERLQTLDVDFSFQGFGRLRVLNVGGLPAELD 199

  Fly   182 LQ--FAHLHDLGHLDLTSCVLANFSLEALGSLPNLHTLILFNVWPIANQLHAICCLRRLCTLDIS 244
            ::  ...|..|..|||::..|...:.....| ..:.:|:|:||......:|.:..:.||..||||
Zfish   200 VEALLQPLPALTALDLSAARLPRPAFLQQWS-DRMASLVLYNVELTDELIHTLLQMTRLRHLDIS 263

  Fly   245 ISSSGNGHGTYDLPDQTLEMLMDNLRHLTHLDISGTNLAGNGVATKESTTTSGMQQSPKMEQHFA 309
            ..:...  ..:.:..:.|..::..|..|..|||||..:..|...|............|.....:.
Zfish   264 RENQRT--SKFKMSRRVLSSVVQTLVQLVSLDISGHIMLDNCTVTPMQEALGRPSTEPSKSSIYP 326

  Fly   310 LTDIPGLASRTQRPLQFLGLYHTAHWACKRHDIPALEVAGDANEQQILTAAR-YYHDRPVLLTRV 373
            ..::       :|||||||||:|.  .|....|||.:|.|..||.|||.|.. |...||.|..|.
Zfish   327 FKEL-------KRPLQFLGLYNTT--LCNVTHIPAYKVTGSKNEDQILNAIEAYTEQRPELAHRA 382

  Fly   374 LNDLYHLFRFENCKDIHTALDVVLSAMDRHLKFKHMQISGSATLFYIVKGRDRSKFGALLRNHII 438
            :|.|:.:.|.::|..:..||.:|::|:..|...|.:|::|||.|||:.....|.:....||..:|
Zfish   383 INQLFDIARIQHCSQLLRALQLVITALKTHKYDKSIQVTGSAALFYLTNTEYRGEQSVRLRRQVI 447

  Fly   439 RTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILLHGVSKTEQEGFVQRIAIYLL 503
            :.:||||| |..:.|:.||..|||..|.:|.::.|:|.|:..:||..:....|:..:||||::|.
Zfish   448 QVVLNGME-HYQEVTVQRNCCLTLCNFSIPEELEFQYRRVNLLLLKILEPLRQDESIQRIAVHLC 511

  Fly   504 NTLACQVDGRQKLFLGELGVVSTMFTLIKDRLTRSVFDDVMEVAWSTMWNVTDETAINCKRFLDG 568
            |.|.||||...|..:|::|.|.||..||:.:|...:.|.|||.:||.:||:||||..||:.||:.
Zfish   512 NALVCQVDNDHKEAVGKMGFVKTMLNLIQKKLQDRMCDQVMEFSWSALWNITDETPDNCQMFLEC 576

  Fly   569 RGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVFARLLDSLSDGIEVGGA 633
            .||..||:||..|||:.||.|||:||||||||||.|||:|:|::||.||:.||||.:||||
Zfish   577 NGMNLFLECLKEFPDKQELHRNMLGLLGNVAEVKALRPQLLTRQFITVFSDLLDSKADGIE---- 637

  Fly   634 SASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIKTPSREHVLERMVAAIQRW 698
                                    |||||.|||:||..||...|:::.|||.||:::|..|||.|
Zfish   638 ------------------------VSYNACGVLSHIMFDGPGVWSMEEPSRTHVMDKMWTAIQSW 678

  Fly   699 NIKSERNINYRSFEPILSLVRCYETPQCQHWAVWALANLTQVYPEKYCKLVEQENGIQILNELIE 763
            ::.|.||||||||||||.|:.....|..||||.|||.||..|||.|||.|:.:|.|:.:|..::|
Zfish   679 DVSSRRNINYRSFEPILRLLPQSGAPVSQHWATWALYNLVSVYPSKYCPLLIKEGGVSLLQAVLE 743

  Fly   764 HESPYCEIKRIARLVIEQCDSGSE 787
            .::.:.|.|.:||.|:|||:|..|
Zfish   744 LQTSHVETKDMARKVMEQCESFKE 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	6/24 (25%)
		leucine-rich repeat	136..167	CDD:275381	13/50 (26%)
		leucine-rich repeat	168..189	CDD:275381	5/22 (23%)
		leucine-rich repeat	190..213	CDD:275381	6/22 (27%)
		ARM	535..628	CDD:237987	55/92 (60%)
zer1	NP_998066.1	leucine-rich repeat	85..107	CDD:275381	6/21 (29%)
		leucine-rich repeat	108..133	CDD:275381	6/24 (25%)
		leucine-rich repeat	134..170	CDD:275381	10/35 (29%)
		leucine-rich repeat	186..209	CDD:275381	5/22 (23%)
		leucine-rich repeat	210..256	CDD:275381	11/46 (24%)
		ARM	524..650	CDD:237987	74/153 (48%)
		armadillo repeat	570..607	CDD:293788	22/36 (61%)
		armadillo repeat	609..649	CDD:293788	27/67 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583526
Domainoid	1	1.000	418	1.000	Domainoid score	I626
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4621
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1780
OMA	1	1.010	-	-		QHG47529
OrthoDB	1	1.010	-	-		D120457at33208
OrthoFinder	1	1.000	-	-		FOG0006960
OrthoInspector	1	1.000	-	-		oto38613
orthoMCL	1	0.900	-	-		OOG6_107901
Panther	1	1.100	-	-	LDO	PTHR12904
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5052
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910