DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12084 and zer1

DIOPT Version :10

Sequence 1:NP_612112.1 Gene:CG12084 / 192509 FlyBaseID:FBgn0043458 Length:793 Species:Drosophila melanogaster
Sequence 2:NP_998066.1 Gene:zer1 / 405837 ZFINID:ZDB-GENE-040426-2307 Length:774 Species:Danio rerio


Alignment Length:804 Identity:291/804 - (36%)
Similarity:413/804 - (51%) Gaps:74/804 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 EEPLTLKEIAYQKLCNNLDIISSHRPDGQR-GLNPGIVLPNEICDGFLENY-------QRFNRPL 71
            ::|.:|..:..:....||.....:..:..| .|.|.:.||:||||..:..|       ..|..  
Zfish     7 DDPDSLMSLCTEFCLRNLRRTMCYSGERNRLSLRPDVFLPSEICDRLVNAYMDLVHTDSEFEP-- 69

  Fly    72 DDSVIRLFEDTHRTSLKIVNLRNSTLSSIGLETLMRHKLFALSLWYCDMISVGSHHLLAHYGDSL 136
            .|...:||.|...|.|..:.||...|....||.:.:..|..|.|..|..:|..:...|:.:..:|
Zfish    70 QDGFFQLFSDPRSTRLTRLTLREDLLRDRDLEAISKQDLMELHLTDCSRLSSRALRTLSSFRHTL 134

  Fly   137 RSLEL----GI----SSHLLQYAEPNEKE-----------PVDFQLT-CPHLRRLVLNGVVMHHR 181
            .||.|    ||    |...|...|.:|::           .|||... ...||.|.:.|:.....
Zfish   135 LSLSLFGCSGIFFRKSGAPLASGEQDEEDEDPLEERLQTLDVDFSFQGFGRLRVLNVGGLPAELD 199

  Fly   182 LQ--FAHLHDLGHLDLTSCVLANFSLEALGSLPNLHTLILFNVWPIANQLHAICCLRRLCTLDIS 244
            ::  ...|..|..|||::..|...:.....| ..:.:|:|:||......:|.:..:.||..||||
Zfish   200 VEALLQPLPALTALDLSAARLPRPAFLQQWS-DRMASLVLYNVELTDELIHTLLQMTRLRHLDIS 263

  Fly   245 ISSSGNGHGTYDLPDQTLEMLMDNLRHLTHLDISGTNLAGNGVATKESTTTSGMQQSPKMEQHFA 309
            ..:...  ..:.:..:.|..::..|..|..|||||..:..|...|............|.....:.
Zfish   264 RENQRT--SKFKMSRRVLSSVVQTLVQLVSLDISGHIMLDNCTVTPMQEALGRPSTEPSKSSIYP 326

  Fly   310 LTDIPGLASRTQRPLQFLGLYHTAHWACKRHDIPALEVAGDANEQQILTAAR-YYHDRPVLLTRV 373
            ..::       :|||||||||:|.  .|....|||.:|.|..||.|||.|.. |...||.|..|.
Zfish   327 FKEL-------KRPLQFLGLYNTT--LCNVTHIPAYKVTGSKNEDQILNAIEAYTEQRPELAHRA 382

  Fly   374 LNDLYHLFRFENCKDIHTALDVVLSAMDRHLKFKHMQISGSATLFYIVKGRDRSKFGALLRNHII 438
            :|.|:.:.|.::|..:..||.:|::|:..|...|.:|::|||.|||:.....|.:....||..:|
Zfish   383 INQLFDIARIQHCSQLLRALQLVITALKTHKYDKSIQVTGSAALFYLTNTEYRGEQSVRLRRQVI 447

  Fly   439 RTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILLHGVSKTEQEGFVQRIAIYLL 503
            :.:||||| |..:.|:.||..|||..|.:|.::.|:|.|:..:||..:....|:..:||||::|.
Zfish   448 QVVLNGME-HYQEVTVQRNCCLTLCNFSIPEELEFQYRRVNLLLLKILEPLRQDESIQRIAVHLC 511

  Fly   504 NTLACQVDGRQKLFLGELGVVSTMFTLIKDRLTRSVFDDVMEVAWSTMWNVTDETAINCKRFLDG 568
            |.|.||||...|..:|::|.|.||..||:.:|...:.|.|||.:||.:||:||||..||:.||:.
Zfish   512 NALVCQVDNDHKEAVGKMGFVKTMLNLIQKKLQDRMCDQVMEFSWSALWNITDETPDNCQMFLEC 576

  Fly   569 RGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVFARLLDSLSDGIEVGGA 633
            .||..||:||..|||:.||.|||:||||||||||.|||:|:|::||.||:.||||.:||||    
Zfish   577 NGMNLFLECLKEFPDKQELHRNMLGLLGNVAEVKALRPQLLTRQFITVFSDLLDSKADGIE---- 637

  Fly   634 SASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIKTPSREHVLERMVAAIQRW 698
                                    |||||.|||:||..||...|:::.|||.||:::|..|||.|
Zfish   638 ------------------------VSYNACGVLSHIMFDGPGVWSMEEPSRTHVMDKMWTAIQSW 678

  Fly   699 NIKSERNINYRSFEPILSLVRCYETPQCQHWAVWALANLTQVYPEKYCKLVEQENGIQILNELIE 763
            ::.|.||||||||||||.|:.....|..||||.|||.||..|||.|||.|:.:|.|:.:|..::|
Zfish   679 DVSSRRNINYRSFEPILRLLPQSGAPVSQHWATWALYNLVSVYPSKYCPLLIKEGGVSLLQAVLE 743

  Fly   764 HESPYCEIKRIARLVIEQCDSGSE 787
            .::.:.|.|.:||.|:|||:|..|
Zfish   744 LQTSHVETKDMARKVMEQCESFKE 767

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12084NP_612112.1 leucine-rich repeat 110..135 CDD:275381 6/24 (25%)
leucine-rich repeat 136..167 CDD:275381 13/50 (26%)
leucine-rich repeat 168..189 CDD:275381 5/22 (23%)
LRR <184..>282 CDD:443914 26/97 (27%)
leucine-rich repeat 190..213 CDD:275381 6/22 (27%)
zer1NP_998066.1 leucine-rich repeat 85..107 CDD:275381 6/21 (29%)
leucine-rich repeat 108..133 CDD:275381 6/24 (25%)
leucine-rich repeat 134..170 CDD:275381 10/35 (29%)
LRR <175..>296 CDD:443914 31/123 (25%)
leucine-rich repeat 186..209 CDD:275381 5/22 (23%)
leucine-rich repeat 210..256 CDD:275381 11/46 (24%)
armadillo repeat 570..607 CDD:293788 22/36 (61%)
armadillo repeat 609..649 CDD:293788 27/67 (40%)

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