DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12084 and Zyg11b

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_038967432.1	Gene:	Zyg11b / 362559	RGDID:	1307814	Length:	744	Species:	Rattus norvegicus

Alignment Length:	816	Identity:	222/816 - (27%)
Similarity:	367/816 - (44%)	Gaps:	142/816 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 MEDGSLDEEPLTLKEIAYQKLCNNLDIISSHRPDGQRGLNPGIVLPNEICDGFLENYQRFNRPLD 72
            ||:.|    |.:|.:|....|..||:...|.|.||...|....|.|.|:.|..|:.. ..:..|:
  Rat    10 MEEAS----PYSLLDICLSFLTTNLEKFCSARQDGTLCLQEPGVFPQEVADRLLQTI-ALHGLLN 69

  Fly    73 DSVIRLFEDTHRTSLKIVNLRNSTLSSIGL-ETLMRHKLFAL-------SLWYCDMISVGSHHLL 129
            |..:.:|.. ::..||...:|.:.:|::.. :....|||..|       .:...|:||
  Rat    70 DGTVGIFRG-NQMRLKRACIRKAKISAVAFRKAFCHHKLVELDATGVNADITITDIIS------- 126

  Fly   130 AHYGDSLRSLELGISSHLLQYAEPNEKEPVDFQLTCPHLRRLVLNGVVMH----HRLQFAHLHDL 190
                        |:.|:  ::.:.|        |.|     ||||.:.:.    :...|:.|..|
  Rat   127 ------------GLGSN--KWIQQN--------LQC-----LVLNSLTLSLEDPYERCFSRLSGL 164

  Fly   191 GHLDLTSCVLANFSLEALGSLPNLHTLILFNVWPIANQLHAICCLRRLCTLDISISSSGNGHGTY 255
            ..|.:|:.:..|..|..:.|||.|.:|.:.|. .|.:....:.|..||.:|.:        |...
  Rat   165 RALSITNVLFYNEDLAEVASLPRLESLDISNT-SITDITALLACKDRLKSLTM--------HHLK 220

  Fly   256 DLPDQTLEML--MDNLRHLTHLDISGTNLAGNGVATK-----------ESTTTSGMQQ-SPKMEQ 306
            .|...|.::|  :..|:||.|||||......:.:|.:           .|...||.:. :.|..:
  Rat   221 CLKMTTTQILDVVRELKHLNHLDISDDKQFTSDIALRLLEQKDILPNLVSLDVSGRKHVTDKAVE 285

  Fly   307 HFALTDIPGLASRTQRP-LQFLGLY-----HTAHWACKRHDIPALEVAGDANEQQILTAARYYHD 365
            .|.|          ||| :||:||.     ::.....|.|    |:|:|:|||.||..|.|.|.:
  Rat   286 AFIL----------QRPSMQFVGLLATDAGYSEFLTGKGH----LKVSGEANETQIAEALRRYSE 336

  Fly   366 RPVLLTRVLNDLYHLFR----FENCK-DIHTALDVVLSAMDRHLKFKHMQISGSATLFYIVKGRD 425
            |...   |...|:|||.    .|..| ||   |.:|::.|..|.....:|::.||.:|.:.|...
  Rat   337 RAFF---VREALFHLFSLTHVMEKTKPDI---LKLVVTGMRNHPMNLPVQLAASACVFNLTKQDL 395

  Fly   426 RSKFGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILLHGVSKTE 490
            .......|...:...||..||.......:.:|..|:|....:..||.|......|:::..:...|
  Rat   396 ALGMPVRLLADVTHLLLKAMEHFPNHQQLQKNCLLSLCSDRILQDVPFNRFEAAKLVMQWLCNHE 460

  Fly   491 QEGFVQRIAIYLLNTLACQVDGRQKLFLG-ELGVVSTMFTLIKDRLTRSVFDDVMEVAWSTMWNV 554
            .:. :||:|:.:::.||.::...|...|| ||.:|..:..::|.:..::..|..::...|.:||:
  Rat   461 DQN-MQRMAVAIISILAAKLSTEQTAQLGAELFIVRQLLQIVKQKTNQNSVDTTLKFTLSALWNL 524

  Fly   555 TDETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVFAR 619
            |||:...|:.|::.:|:|.|::.|.:||....:.:.::|||.|:|||:.|..:||.::||:..:.
  Rat   525 TDESPTTCRHFIENQGLELFMRVLESFPTESSIQQKVLGLLNNIAEVQELHSELMWKDFIDHISS 589

  Fly   620 LLDSLSDGIEVGGASASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIKTPSR 684
            ||.|    :||                          :|||.|||::||:.|.|..|||:....|
  Rat   590 LLHS----VEV--------------------------EVSYFAAGIIAHLISRGEQAWTLSRSQR 624

  Fly   685 EHVLERMVAAIQRWNIKSERNINYRSFEPILSLVRCYETPQCQHWAVWALANLTQVYPEKYCKLV 749
            ..:|:.:.:||.:|.......:.||||.|...|:.|:.||..|.|||||:.::....|.:||.::
  Rat   625 NSLLDDLHSAILKWPTPECEMVAYRSFNPFFPLLGCFTTPGVQLWAVWAMQHVCSKNPSRYCSML 689

  Fly   750 EQENGIQILNELIEHE--SPYCEIKRIARLVIEQCD 783
            .:|.|:|.|..:.|||  .||  :::||..:::..:
  Rat   690 IEEGGLQHLYNIKEHEQTDPY--VQQIAVAILDSLE 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	5/31 (16%)
		leucine-rich repeat	136..167	CDD:275381	5/30 (17%)
		leucine-rich repeat	168..189	CDD:275381	6/24 (25%)
		leucine-rich repeat	190..213	CDD:275381	7/22 (32%)
		ARM	535..628	CDD:237987	30/92 (33%)
Zyg11b	XP_038967432.1	leucine-rich repeat	107..136	CDD:275381	7/49 (14%)
		leucine-rich repeat	138..163	CDD:275381	8/29 (28%)
		inl_like_NEAT_1	<143..>248	CDD:411101	32/113 (28%)
		leucine-rich repeat	164..187	CDD:275381	7/22 (32%)
		leucine-rich repeat	188..210	CDD:275381	5/22 (23%)
		leucine-rich repeat	211..238	CDD:275381	7/34 (21%)
		leucine-rich repeat	239..267	CDD:275381	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920