DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12084 and Zer1

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	XP_008759877.1	Gene:	Zer1 / 311842	RGDID:	1310284	Length:	801	Species:	Rattus norvegicus

Alignment Length:	824	Identity:	303/824 - (36%)
Similarity:	429/824 - (52%)	Gaps:	90/824 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CKVRLMEDGSLDEEPLTLKEIAYQKLCNNLDIISSHRPDGQR-GLNPGIVLPNEICDGFLENYQR 66
            |...|.......:.|.:|..:.......|||....:..|.:. .|:|.|.||:||||..:..|..
  Rat    22 CGPLLPSPDMASDTPESLMALCTDFCLRNLDGTLGYLLDKETLRLHPDIFLPSEICDQLVNEYVE 86

  Fly    67 FNRPL-----DDSVIRLFEDTHRTSLKIVNLRNSTLSSIGLETLMRHKLFALSLWYCDMISVGSH 126
            .....     .::...||.|...|.|..::||...:....||.:.:..|..|.|..|:.:|..|.
  Rat    87 LVSAACTFEPHETFFSLFSDPRSTRLTRIHLREDLVQDQDLEAIRKQDLVELYLTNCEKLSAKSL 151

  Fly   127 HLLAHYGDSLRSLELGISSHLLQYAEPNEKEPVDFQLTCPHLRRLV------------------- 172
            ..|..:..||.||.|...:::. |.|.|.....|..|..|..:.||
  Rat   152 QTLRSFSHSLVSLSLFGCANIF-YEEDNPGGCEDECLVNPTCQVLVKDFTFEGFSRLRFLNLGRM 215

  Fly   173 LNGVVMHHRLQFAHLHDLGHLDLTSCVL--ANFSLEALGSLPNLHTLILFNVWPIANQLHAICCL 235
            ::|:.:...|:  .|:.|..|||:....  |.|..:...|   |.:|:|:|:....:.:..|..|
  Rat   216 IDGIPVESLLR--PLNSLTALDLSGIQTSDATFLTQWKDS---LMSLVLYNMDLSDDHIRVIVQL 275

  Fly   236 RRLCTLDIS---ISSSGNGHGTYDLPDQTLEMLMDNLRHLTHLDISGTNLAGNGVATK---ESTT 294
            .:|..||||   :||    :..:.|..:.|.:|:..|.:|..|||||..:..|...:|   |:..
  Rat   276 HKLRHLDISRDRLSS----YYKFKLTRKVLSLLVQKLGNLMSLDISGHMILENCSISKTDEEAGQ 336

  Fly   295 TSGMQQSPKMEQHFALTDIPGLASRTQRPLQFLGLYHTAHWACKRHDIPALEVAGDANEQQILTA 359
            ||.......:....||          :||||||||:.|:  .|:...|||.:|:||.||:|:|.|
  Rat   337 TSTEPSKSSIMPFRAL----------KRPLQFLGLFETS--LCRLTHIPAYKVSGDKNEEQVLNA 389

  Fly   360 ARYYHD-RPVLLTRVLNDLYHLFRFENCKDIHTALDVVLSAMDRHLKFKHMQISGSATLFYIVKG 423
            ...|.: ||.:.:|.:|.|:.:.|.|.|..:..||.:|::|:..|...|::|::|||.|||:...
  Rat   390 IEAYTEHRPEITSRAINLLFDIARIERCNQLLRALKLVITALKCHKYDKNIQVTGSAALFYLTNS 454

  Fly   424 RDRSKFGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILLHGVSK 488
            ..||:....||..:|:.:|||||.: .:.|:.||..|||..|.:|.::.|:|.|:.::||..:|.
  Rat   455 EYRSEQSVKLRRQVIQVVLNGMESY-QEVTVQRNCCLTLCNFSIPEELEFQYRRVNELLLGILSP 518

  Fly   489 TEQEGFVQRIAIYLLNTLACQVDGRQKLFLGELGVVSTMFTLIKDRLTRSVFDDVMEVAWSTMWN 553
            |.|:..:||||::|.|.|.||||...|..:|::|.|.||..||:.:|.....|.|||.:||.:||
  Rat   519 TRQDESIQRIAVHLCNALVCQVDNDHKEAVGKMGFVVTMLKLIQKKLLDKTCDQVMEFSWSALWN 583

  Fly   554 VTDETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVFA 618
            :||||..||:.||:..||:.||.||..||::.||.|||:||||||||||.|||:|||.:||.||:
  Rat   584 ITDETPDNCEMFLNFNGMKLFLDCLKEFPEKQELHRNMLGLLGNVAEVKGLRPQLMTSQFISVFS 648

  Fly   619 RLLDSLSDGIEVGGASASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIKTPS 683
            .||:|.:||||                            |||||.|||:||..||.:||.:..|.
  Rat   649 NLLESKADGIE----------------------------VSYNACGVLSHIMFDGPEAWGVCEPQ 685

  Fly   684 REHVLERMVAAIQRWNIKSERNINY-----RSFEPILSLVRCYETPQCQHWAVWALANLTQVYPE 743
            |..|.|||.||||.|:|.|.|||||     |||||||.|:....:|..||||.|||.||..|||:
  Rat   686 RAEVEERMWAAIQSWDINSRRNINYRSEMGRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPD 750

  Fly   744 KYCKLVEQENGIQILNELIEHESPYCEIKRIARLVIEQCDSGSE 787
            |||.|:.:|.|:.:|.:||:..:...|.|.:||.|||.|.:..|
  Rat   751 KYCPLLIKEGGMPLLRDLIKMVTARQETKEMARKVIEHCSNFRE 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	7/24 (29%)
		leucine-rich repeat	136..167	CDD:275381	9/30 (30%)
		leucine-rich repeat	168..189	CDD:275381	5/39 (13%)
		leucine-rich repeat	190..213	CDD:275381	7/24 (29%)
		ARM	535..628	CDD:237987	54/92 (59%)
Zer1	XP_008759877.1	leucine-rich repeat	112..134	CDD:275381	5/21 (24%)
		leucine-rich repeat	135..160	CDD:275381	7/24 (29%)
		leucine-rich repeat	161..191	CDD:275381	9/30 (30%)
		leucine-rich repeat	207..230	CDD:275381	3/24 (13%)
		leucine-rich repeat	231..253	CDD:275381	6/21 (29%)
		leucine-rich repeat	254..277	CDD:275381	6/22 (27%)
		leucine-rich repeat	311..354	CDD:275380	13/52 (25%)
		ARM	546..672	CDD:237987	73/153 (48%)
		armadillo repeat	592..629	CDD:293788	21/36 (58%)
		armadillo repeat	631..671	CDD:293788	27/67 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343228
Domainoid	1	1.000	435	1.000	Domainoid score	I549
eggNOG	1	0.900	-	-		E1_KOG3665
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4621
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1641
OMA	1	1.010	-	-		QHG47529
OrthoDB	1	1.010	-	-		D120457at33208
OrthoFinder	1	1.000	-	-		FOG0006960
OrthoInspector	1	1.000	-	-		oto98550
orthoMCL	1	0.900	-	-		OOG6_107901
Panther	1	1.100	-	-	LDO	PTHR12904
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5052
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770