Protein Alignment CG12084 and Zyg11a

DIOPT Version :10

• Sequence 1: NP_612112.1
• Gene: CG12084 / 192509
• FlyBaseID: FBgn0043458
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: XP_006503039.1
• Gene: Zyg11a / 230590
• MGIID: 2446208
• Length: 760
• Species: Mus musculus
• Alignment Length: 836
• Identity: 212/836 - (25%)
• Similarity: 338/836 - (40%)
• Gaps: 193/836 - (23%)

  Fly    14 DEEPLTLKEIAYQKLCNNLDIISSHRPDGQRGLNPGIVLPNEICDGFLENYQRFNRPLDDSVIRL 78
            :..|.:|..|....|...||...|.||||...|......|:||.|.|||. ..:...|.|....:
Mouse    32 EASPYSLVNICLDVLIAELDKWCSKRPDGTLCLPEHWYFPHEIADKFLER-MAWQGKLTDRTASI 95

  Fly    79 FEDTHRTSLKIVNLRNSTLSSIGL-ETLMRHKLFALSLWYCDMISVGSHHLLAHYGDSLRSLELG 142
            |:. .:.|||::|:....||:... :....|||..:     :..||.| .|||  .|.:.:|:
Mouse    96 FQG-KQMSLKLINIPRVKLSAAAFTKAFCHHKLIEV-----NATSVDS-ELLA--PDIIHALQ-- 149

  Fly   143 ISSHLLQYAEPNEKEPVDFQLTCPHLRRLVLNG---------VVMHHRLQFAHLHDLGHLDLTSC 198
             ||..:|                .:|:.|||:.         |.:.|   |..||.|...:::.|
Mouse   150 -SSAWIQ----------------KNLQCLVLDSVSIPPNSGLVALSH---FTGLHTLSVANVSFC 194

  Fly   199 VLANFSLEALGSLPNLHTLILFNVWPIAN--------------QLHAICCL-----------RRL 238
               |..|.::..||||.:|.:.|.. :.|              .:|.:.||           |:|
Mouse   195 ---NEDLVSVSQLPNLGSLDISNTL-VTNISALLSCKNRLRSLTMHYLKCLAMNSPQVLAVIRQL 255

  Fly   239 -CTLDISISSSGNGHGTYDLPDQTLEMLMDNLRHLTHLDISGTNLAGNGVATKESTTTSGMQQSP 302
             |.|.:.||.......  ||....|:. .|.|.:||.|||||      |....:....|.:|..|
Mouse   256 KCLLHLDISDHQQLRS--DLAFYLLQQ-KDILPNLTSLDISG------GTDVTDQAVESFLQHRP 311

  Fly   303 KMEQHFALTDIPGLASRTQRPLQFLGLYHT-----AHWACKRHDIPALEVAGDANEQQILTAARY 362
            .|                    :|:||.:|     ..:..|:    .|:|||.||..||..|...
Mouse   312 AM--------------------RFVGLLYTDAGYSDFFTAKQ----GLKVAGGANMSQISEALSR 352

  Fly   363 YHDRPVLLTRVLNDLYHLFR-FENCKDIHTALDVVLS----AMDRHLKFKHMQISGSATLFYIVK 422
            |.:|...:...      ||| |.....:...|.|:|.    .|..|.....:|.:.||....:.:
Mouse   353 YRNRSCFVKEA------LFRLFTETLSLRAVLPVMLKLVAIGMRNHPLDLPVQFTASACALNLTR 411

  Fly   423 GRDRSKFGALLRNHIIRTLLNGMEMHITD------------DTMLRNGYLTLTQFHMPVDVLFEY 475
            ..       |.|...:|.|     ..|||            ..:.:|..|:||...:.:||.|:.
Mouse   412 QE-------LARGMPVRLL-----AEITDLLFKATKNFPYYQQLQKNCLLSLTSSRILMDVPFDR 464

  Fly   476 ERLIKILLHGVSKTEQEGFVQRIAIYLLNTLACQVDGRQKLFLGELG-----VVSTMFTLIKDRL 535
            ....|:.|..|.:.|... ::.:|:.:.:.||.::...:   :|:|.     .:..:.|:|:.:|
Mouse   465 FDAAKLALRWVCRRESPK-LRTMAVSITSILALKLSPEE---MGQLQEELIMAIKELLTIIRQKL 525

  Fly   536 TRSVFDDVMEVAWSTMWNVTDETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAE 600
            ..::.|.........:||:|||..:.||.|::..|:...::.|.|| ....:...::|||.||||
Mouse   526 AENLDDVTFLFTLKALWNLTDECPLACKYFMENEGLATVIRVLETF-SISVIQSKVLGLLNNVAE 589

  Fly   601 VKWLRPKLMTQEFIEVFARLLDSLSDGIEVGGASASVVARVREREMASANHAYLRFQVSYNAAGV 665
            |:.|..||:|::.||....||.|.:                              .:||:.||||
Mouse   590 VRELSSKLVTEDVIERIISLLHSSN------------------------------LEVSFLAAGV 624

  Fly   666 LAHIASDGADAWTIKTPSREHVLERMVAAIQRWNIKSER-----NINYRSFEPILSLVRCYETPQ 725
            |||:..| ...|..:...|..:|..:..|||.|  .|.|     .:.||||:....|:..:..|:
Mouse   625 LAHLTCD-RQHWLSRDLQRTDLLRYLHLAIQNW--PSSRCDMSVLVTYRSFKAFSPLLVNFSQPE 686

  Fly   726 CQHWAVWALANLTQVYPEKYCKLVEQENGIQILNELIEHESPYCEIKRIARLVIEQ 781
            .|.||:||:.::....|.|||:|:.:..|:|::.::.||.....:::::...::|:
Mouse   687 VQRWALWAIHHVCSKNPSKYCQLLVEGGGLQLMYDIQEHGQASAQVRQMVSSILEE 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	7/24 (29%)
		leucine-rich repeat	136..167	CDD:275381	4/30 (13%)
		leucine-rich repeat	168..189	CDD:275381	8/29 (28%)
		LRR	<184..>282	CDD:443914	35/123 (28%)
		leucine-rich repeat	190..213	CDD:275381	5/22 (23%)
Zyg11a	XP_006503039.1	LRR	<156..331	CDD:443914	50/210 (24%)
		leucine-rich repeat	158..182	CDD:275381	7/26 (27%)
		leucine-rich repeat	183..206	CDD:275381	7/25 (28%)
		leucine-rich repeat	207..229	CDD:275381	4/22 (18%)
		leucine-rich repeat	230..257	CDD:275381	5/26 (19%)
		leucine-rich repeat	258..286	CDD:275381	8/30 (27%)
		leucine-rich repeat	287..309	CDD:275381	9/27 (33%)