DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12084 and Zer1

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_848809.2	Gene:	Zer1 / 227693	MGIID:	2442511	Length:	779	Species:	Mus musculus

Alignment Length:	820	Identity:	300/820 - (36%)
Similarity:	428/820 - (52%)	Gaps:	98/820 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EEPLTLKEIAYQKLCNNLDIISSHRPDGQR-GLNPGIVLPNEICDGFLENYQRFNRPL-----DD 73
            :.|.:|..:.......|||....:..|.:. .|:|.|.||:||||..:..|.......     .:
Mouse     4 DTPESLMALCTDFCLRNLDGTLGYLLDKETLRLHPDIFLPSEICDQLVNEYVELVSAACTFEPHE 68

  Fly    74 SVIRLFEDTHRTSLKIVNLRNSTLSSIGLETLMRHKLFALSLWYCDMISVGSHHLLAHYGDSLRS 138
            :...||.|...|.|..::||...:....||.:.:..|..|.|..|:.:|..|...|..:..||.|
Mouse    69 TFFSLFSDPRSTRLTRIHLREDLVQDQDLEAIRKQDLVELYLTNCEKLSAKSLQTLRSFRHSLVS 133

  Fly   139 LELGISSHLLQYAEPNEKEPVDFQLTCPHLRRLV-------------------LNGVVMHHRLQF 184
            |.|...:::. |.|.|.....|..|..|..:.||                   ::|:.:...|:
Mouse   134 LSLSGCANIF-YEEDNPGGCEDECLVNPTCQVLVKDFTFEGFSRLRFLNLGRMIDGIPVESLLR- 196

  Fly   185 AHLHDLGHLDLTSCVL--ANFSLEALGSLPNLHTLILFNVWPIANQLHAICCLRRLCT------- 240
             .|:.|..|||:....  |.|..:...|   |.:|:|:|:....:.:..|..|.:|.:
Mouse   197 -PLNSLAALDLSGIQTSDATFLTQWKDS---LMSLVLYNMDLSDDHIRVIVQLHKLRSKILTCGP 257

  Fly   241 ------LDIS---ISSSGNGHGTYDLPDQTLEMLMDNLRHLTHLDISGTNLAGNGVATK---EST 293
                  ||||   :||    :..:.|..:.|.:|:..|.:|..|||||..:..|...:|   |:.
Mouse   258 HLISSHLDISRDRLSS----YYKFKLTRKVLSLLVQKLGNLMSLDISGHMILENCSISKTDEEAG 318

  Fly   294 TTSGMQQSPKMEQHFALTDIPGLASRTQRPLQFLGLYHTAHWACKRHDIPALEVAGDANEQQILT 358
            .||.......:....||          :||||||||:.|:  .|:...|||.:|:||.||:|:|.
Mouse   319 QTSTEPSKSSIMPFRAL----------KRPLQFLGLFETS--LCRLTHIPAYKVSGDKNEEQVLN 371

  Fly   359 AARYYHD-RPVLLTRVLNDLYHLFRFENCKDIHTALDVVLSAMDRHLKFKHMQISGSATLFYIVK 422
            |...|.: ||.:.:|.:|.|:.:.|.|.|..:..||.:|::|:..|...|::|::|||.|||:..
Mouse   372 AIEAYTEHRPEITSRAINLLFDIARIERCNQLLRALKLVITALKCHKYDKNIQVTGSAALFYLTN 436

  Fly   423 GRDRSKFGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILLHGVS 487
            ...||:....||..:|:.:|||||.: .:.|:.||..|||..|.:|.::.|:|.|:.::||..:|
Mouse   437 SEYRSEQSVKLRRQVIQVVLNGMESY-QEVTVQRNCCLTLCNFSIPEELEFQYRRVNELLLGILS 500

  Fly   488 KTEQEGFVQRIAIYLLNTLACQVDGRQKLFLGELGVVSTMFTLIKDRLTRSVFDDVMEVAWSTMW 552
            .|.|:..:||||::|.|.|.||||...|..:|::|.|.||..||:.:|.....|.|||.:||.:|
Mouse   501 PTRQDESIQRIAVHLCNALVCQVDNDHKEAVGKMGFVVTMLKLIQKKLLDKTCDQVMEFSWSALW 565

  Fly   553 NVTDETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVF 617
            |:||||..||:.||:..||:.||.||..||::.||.|||:||||||||||.|||:|||.:||.||
Mouse   566 NITDETPDNCEMFLNFNGMKLFLDCLKEFPEKQELHRNMLGLLGNVAEVKELRPQLMTSQFISVF 630

  Fly   618 ARLLDSLSDGIEVGGASASVVARVREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIKTP 682
            :.||:|.:||||                            |||||.|||:||..||.:||.:..|
Mouse   631 SNLLESKADGIE----------------------------VSYNACGVLSHIMFDGPEAWGVCEP 667

  Fly   683 SREHVLERMVAAIQRWNIKSERNINYRSFEPILSLVRCYETPQCQHWAVWALANLTQVYPEKYCK 747
            .|..|.:||.||||.|:|.|.||||||||||||.|:....:|..||||.|||.||..|||:|||.
Mouse   668 QRAEVEDRMWAAIQSWDINSRRNINYRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPDKYCP 732

  Fly   748 LVEQENGIQILNELIEHESPYCEIKRIARLVIEQCDSGSE 787
            |:.:|.|:.:|.:||:..:...|.|.:||.|||.|.:..|
Mouse   733 LLIKEGGMPLLRDLIKMATARQETKEMARKVIEHCSNFRE 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	7/24 (29%)
		leucine-rich repeat	136..167	CDD:275381	9/30 (30%)
		leucine-rich repeat	168..189	CDD:275381	5/39 (13%)
		leucine-rich repeat	190..213	CDD:275381	7/24 (29%)
		ARM	535..628	CDD:237987	54/92 (59%)
Zer1	NP_848809.2	leucine-rich repeat	82..104	CDD:275381	5/21 (24%)
		leucine-rich repeat	105..130	CDD:275381	7/24 (29%)
		leucine-rich repeat	131..161	CDD:275381	9/30 (30%)
		leucine-rich repeat	177..200	CDD:275381	3/24 (13%)
		leucine-rich repeat	201..223	CDD:275381	6/21 (29%)
		leucine-rich repeat	224..247	CDD:275381	6/22 (27%)
		LRR 1	226..245		4/18 (22%)
		LRR 2	246..281		8/38 (21%)
		LRR 3	291..315		9/23 (39%)
		ARM 1	440..480		17/40 (43%)
		ARM 2	524..569		18/44 (41%)
		ARM	529..655	CDD:237987	73/153 (48%)
		ARM 3	571..613		24/41 (59%)
		armadillo repeat	575..613	CDD:293788	22/37 (59%)
		ARM 4	615..656		28/68 (41%)
		armadillo repeat	618..654	CDD:293788	24/63 (38%)
		ARM 5	727..769		18/41 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839412
Domainoid	1	1.000	434	1.000	Domainoid score	I569
eggNOG	1	0.900	-	-		E1_KOG3665
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4621
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1683
Isobase	1	0.950	-	0	Normalized mean entropy	S5080
OMA	1	1.010	-	-		QHG47529
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006960
OrthoInspector	1	1.000	-	-		oto95054
orthoMCL	1	0.900	-	-		OOG6_107901
Panther	1	1.100	-	-	LDO	PTHR12904
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2960
SonicParanoid	1	1.000	-	-		X5052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740