DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12084 and K05C4.9

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001362175.1	Gene:	K05C4.9 / 187021	WormBaseID:	WBGene00010585	Length:	718	Species:	Caenorhabditis elegans

Alignment Length:	887	Identity:	175/887 - (19%)
Similarity:	302/887 - (34%)	Gaps:	311/887 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TLKEIAYQKLCNNLDIISSHRPDGQRGLNPGIVLPNEICDGFLEN--YQRFNR-PLDDSVIRLFE 80
            ||..:|.||:..:  |...|..|    :|...:|     |....|  |..|.: |.....||:.|
Worm     4 TLYNLAVQKVATS--IAEGHYED----MNETFIL-----DSKASNLIYAAFIKIPTSKKAIRIPE 57

  Fly    81 DTHRTSLKIVNLRNSTLSSIGLETLMRHK-LFALSL---------WYCDMISVGSHHLLAHYGDS 135
            ..  .:|..|:|||:||....:|.|...: |.:|:|         :.|:   .|..:::|...|.
Worm    58 LV--LNLTNVDLRNTTLCHNTIEMLRTQRTLESLALGSLLLIKKDYLCE---TGRTNIVALLKDI 117

  Fly   136 LRSLELGISSHLLQYAEPNEKEPVDFQLTCPHLRRLVLNGVVMHHRLQFAHLHDLGHLDLTSCVL 200
            |                 |||.                       |.:..||:..| ..|..|
Worm   118 L-----------------NEKS-----------------------RKRLRHLNIRG-AGLIGC-- 139

  Fly   201 ANFSLEALGSLPNLHTLILFNVWPIANQLHAIC-CLRRLCTLDISISSSGNGHGTYDLPDQTLEM 264
             .:|.:.....|:|.||.:.|:....::|..:| ....||.||||.::..:.||
Worm   140 -GWSDKLSELFPSLKTLNVSNILFENDELLRLCVSFPSLCVLDISGTNIASLHG----------- 192

  Fly   265 LMDNLRHLTHLDI---------------SGTNLAGNGVATKESTTTS---------GMQQSPKM- 304
             :.||::|..|.|               ..|||....::..::..||         || ..|::
Worm   193 -LSNLKNLQELSIRYLEFANANNLVDLFQLTNLKVLDMSKSKNLETSKNVLRFVECGM-NLPELR 255

  Fly   305 ----------EQHFALTDIPGLASRTQRPLQFL-GLYHTAHWACK-RHDIPALE--VAGDANEQQ 355
                      |:.||            :.|.|| .|...|...|: :|.:.:.|  |...|..:.
Worm   256 VLDCSGTDIDEELFA------------KLLSFLPNLQQIALMDCQLKHAVFSTEIRVLNSATLET 308

  Fly   356 ILTAARYYH--DRPVLLTRVLNDLYHLFR---FENCK-DIHTALDVVLSAMDRHLKFKHMQISGS 414
            ......||.  .:...:.:...|::.|.:   .:|.: ||...|.:::..|::.:  .|:|
Worm   309 SFQTLNYYSKLKKSDSVMKCFQDIFFLLKEYYTQNKEYDIAGCLAILIRTMEQFV--THVQ---- 367

  Fly   415 ATLFYIVKGRDRSKFGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERL- 478
                   |.|:...|..   ::|               |...:|.|.:|:.     |....:||
Worm   368 -------KTREFLSFNP---SYI---------------TTYASGILCVTEI-----VSNNAQRLR 402

  Fly   479 -------IKILLHGVSKTEQEG--FVQRIAIYLLNTLACQVDGRQKLFLGELGVVSTMFTLIKDR 534
                   :::||:.:...:..|  |.|    ||.|::...:   |.|...:|.:::
Worm   403 PVCAVTALRVLLNFIHNFDHLGSNFTQ----YLRNSIWSAI---QTLVTLDLSIIN--------- 451

  Fly   535 LTRSVFDDVMEVAWSTMWNVTD--ETAINCKRFLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGN 597
                 :|||.:.|...:..|.|  :.|:...:.|           ::.||.:.:..:  :...|.
Worm   452 -----YDDVCDAAVCCLAEVFDTFDIAVPILQVL-----------VYCFPRKRDKFK--VSKEGT 498

  Fly   598 VAEVKWLRPKL-MTQEFIEVFARLLDSLSDGI---------------EVGGAS------------ 634
            :.:.|.|...| :..:|...:..|..|:.|.|               |..||.
Worm   499 IKDSKILIRNLHLCMKFTPYYTPLCQSIIDIIFCPIMDDPQTCLHIVENKGAKDLFNAINKFDNE 563

  Fly   635 --ASVVARVREREMASANHA---YLRFQVSYNAAGVLAHIASDGADAWTIKTPSREHVLERMVAA 694
              ...:.|:.:|.:..||.:   ::.|.|.|         .....:.|   ...|.::|..:.:.
Worm   564 PLQLEILRILKRLVVCANASFENFIEFNVKY---------LKKTFNKW---KSDRLYLLHSIFSI 616

  Fly   695 IQRWNIKSERNI-------NYRSFE---------PILSLVRCYETPQCQHWAVWALANLTQVYPE 743
            :.....:..||.       ||...|         ||...:  :.:.|.....:|||..:     |
Worm   617 LLNQTRRGFRNYVNRLLRNNYHRLETSEIVDIDLPIFHSL--FASTQFDGPILWALFKI-----E 674

  Fly   744 KYC-------KLVEQENGIQILNELIEHESPYCEIKRIARLV 778
            |:.       ::||:.|   |||.:|       .||..::||
Worm   675 KFLEQHDDGRRIVEKFN---ILNLII-------NIKIKSKLV 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	6/33 (18%)
		leucine-rich repeat	136..167	CDD:275381	4/30 (13%)
		leucine-rich repeat	168..189	CDD:275381	3/20 (15%)
		leucine-rich repeat	190..213	CDD:275381	4/22 (18%)
		ARM	535..628	CDD:237987	18/95 (19%)
K05C4.9	NP_001362175.1	leucine-rich repeat	126..151	CDD:275381	6/28 (21%)
		leucine-rich repeat	152..176	CDD:275381	6/23 (26%)
		leucine-rich repeat	177..198	CDD:275378	10/32 (31%)
		leucine-rich repeat	199..223	CDD:275378	3/23 (13%)
		leucine-rich repeat	224..253	CDD:275378	5/29 (17%)
		leucine-rich repeat	254..278	CDD:275378	6/35 (17%)
		leucine-rich repeat	279..290	CDD:275378	3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810