DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12084 and K05C4.3

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_001361868.1	Gene:	K05C4.3 / 187018	WormBaseID:	WBGene00010580	Length:	419	Species:	Caenorhabditis elegans

Alignment Length:	487	Identity:	94/487 - (19%)
Similarity:	154/487 - (31%)	Gaps:	188/487 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 HYGDSLRSLELG-----------ISSHLLQYAEPNEKEPVDFQLTCPHLRRLVLNGVVMHHRL-- 182
            ||.:...|..|.           :::..|...|.|:.:.:.|.||...|:   :|  ::||..
Worm    21 HYQNRKESCSLDPKSSNQIFATLLNNRFLLSCELNDIKGLVFNLTDVDLK---MN--LIHHESMK 80

  Fly   183 -------------QFAHLH--------------------------DLGHLDLTSCVLANF--SLE 206
                         .||.:|                          .|.||::.|..|.::  |.:
Worm    81 MTKSHCLDSLALGSFAFVHRDYFCGIKRINIVGILNDILNKGSQTKLKHLEIRSAGLVSYGWSTK 145

  Fly   207 ALGSLPNLHTL----ILFNVWPIANQLHAICCLRRLCTLDISISSSGNGHGTYDLPDQTLEMLMD 267
            ....||:|.:|    |:|        |..|..|:.|..|.|.           ||..:..|.|||
Worm   146 ISDMLPSLKSLKVTYIVF--------LKGISKLKNLQQLSIR-----------DLEFRDCENLMD 191

  Fly   268 -----NLRHLTH---------------------------LDISGTNLAGNGVATKESTTTSGMQQ 300
                 |||.|..                           :|.|||::       :|.......:.
Worm   192 LFKLFNLRTLEMSKSKPLETSKNIRRFVECGMALPALRVMDCSGTDI-------EEELFAKLSRS 249

  Fly   301 SPKMEQHFALTDIPGLASRTQRPLQFLGLYHTAHWACKRHDIPALEVAGDANEQQILTAARYYHD 365
            .||:|: |||.:.         .||:..|            :..:.|...|.....|....||.|
Worm   250 HPKLEK-FALLNC---------HLQYSTL------------LTKITVLNSATLASSLETLNYYTD 292

  Fly   366 --RPVLLTRVLNDLYHLFRFENCKDIHTALDVVLSAMDRHLKFKHMQISGSATLFYIVKGRDRSK 428
              |.....:.|:|:..|.|..|..|....|.::...::..:                   .|...
Worm   293 LKRSEPAKKCLSDMLFLLRQRNEYDWADCLKIIFRVIETFV-------------------TDTCS 338

  Fly   429 FGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILL---HGVSKTE 490
            .|:....|.| .:|...|:...:..:||           |:|.    .:.::|||   :.:::|:
Worm   339 LGSATTPHTI-GILCVAEIATNNAELLR-----------PIDA----TKSLRILLNLTYTLNRTD 387

  Fly   491 QE---GFVQRI--AIYLLNTLACQVDGRQKLF 517
            .:   |..:.|  ||::.......:..|..||
Worm   388 TDITRGLKESIWLAIFIFVFWKKHIPIRYSLF 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	2/3 (67%)
		leucine-rich repeat	136..167	CDD:275381	8/41 (20%)
		leucine-rich repeat	168..189	CDD:275381	7/61 (11%)
		leucine-rich repeat	190..213	CDD:275381	7/24 (29%)
		ARM	535..628	CDD:237987
K05C4.3	NP_001361868.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810