Protein Alignment CG12084 and F53G2.1

DIOPT Version :10

• Sequence 1: NP_612112.1
• Gene: CG12084 / 192509
• FlyBaseID: FBgn0043458
• Length: 793
• Species: Drosophila melanogaster
• Sequence 2: NP_494284.1
• Gene: F53G2.1 / 186184
• WormBaseID: WBGene00018766
• Length: 714
• Species: Caenorhabditis elegans
• Alignment Length: 711
• Identity: 133/711 - (18%)
• Similarity: 243/711 - (34%)
• Gaps: 218/711 - (30%)

  Fly    20 LKEIAYQKLC-NNLDIISSHRPDGQRGLNPGIVLPNEICDGFLENYQRFNRPLDDSVIRLFEDTH 83
            |::...:.|| .||..|:|...|.|:.:|        ||  :|.:|.            |.||:.
 Worm    78 LQKSCLKSLCLGNLKNIASFFEDDQKSIN--------IC--YLLSYY------------LNEDSR 120

  Fly    84 RT-------------------------SLKIVNLRNST---------------LSSIGLETLMRH 108
            |.                         ||..:::|..|               |.|:.:......
 Worm   121 RNLQTLDLSGKEEFSTGWTVKIGHMFPSLTTLSIRGRTLYKKEFLVVCQNFPKLISLDISDTNVQ 185

  Fly   109 KLFALS-LWYCDMISVGSHHLLAHYG----DSLRSLE-LGISSHLLQYAEPNEKEPVDFQLTCPH 167
            .||.:| |.:...:::.:...|:|:.    ..|..|| |.||...|.......::.||..:...:
 Worm   186 LLFGISYLIHLRELTMQNLTFLSHFVWLDLFHLSGLEFLDISRDKLNKDMKTVRQYVDCGMGLSN 250

  Fly   168 LRRLVLNGVVMHHR----LQFAHLHDLGHLDLTSCVLANFSLEALGSLPNLHTLIL------FNV 222
            ||.|..:|..:..:    ||.:| ..|..:.:...||...::::.|.: .|:|..|      .|.
 Worm   251 LRFLDCSGTDIDDQLVQCLQLSH-PKLKQICVFDSVLQRSTIQSAGMM-TLNTATLGSSLNCLNY 313

  Fly   223 WPIANQLHAIC-CLRRLCTLDISISSSGNGHGTYDLPDQTLEMLMDNLRHLTHLD--------IS 278
            :....:.:|:. ||:.:           |.| .|:..|       |.|.|...::        .|
 Worm   314 FVARRKEYAVWKCLKEI-----------NTH-VYNTKD-------DELNHTNFINCTLRAMNTFS 359

  Fly   279 GTNLAGNGVATKESTTTSGMQQSPKMEQHFAL-------TDIPGLASRTQRPLQFLGLYHTAHWA 336
            ..|:...|:......:.....:.|.:|:..||       .|:|.|.|     |..|| :|.|.|
 Worm   360 SKNVGDEGIRCLVQISMQETMKMPILERSLALKRLSNFIVDLPSLDS-----LDRLG-FHVAVW- 417

  Fly   337 CKRHDIPALEVAGDANEQQILTAARYYHDRPVLLTRVLNDLYHLFRFENCKDIHTALDVVLSAMD 401
                             |.:..          ||:...||       .:|:.|.      |:||.
 Worm   418 -----------------QAVFN----------LLSNFPND-------SDCEKIW------LAAMG 442

  Fly   402 RHLKFKHMQI---SGSATLFYI---VKGRDRSKFGALLRNHIIRTL------LNGMEMHITDDTM 454
             .|:..|:.:   :|..|:.::   :..:|:....|..|.|:::..      ||..|.::|...|
 Worm   443 -FLQKNHISVYCQTGVLTVLHMCTTIMTQDQLSLFAEKRPHMLQLFLALNWSLNKKEHNLTRCIM 506

  Fly   455 LRNGYLTLTQFHMP--------VDVLFEYER----------LIKILLHGVSKTEQE--GFVQRIA 499
            ....|||.:.:...        |.||.:..|          .:.::::.....|.:  |...|:.
 Worm   507 HIIHYLTKSSYEACKYLEGINFVSVLLDCMRSFNNDQINVQCLAVMVNLARHLEYKCFGIKMRLD 571

  Fly   500 IYLLNTLACQVDGRQKLFLGELGVVSTMFTLIKDRLTRSVFDDVMEVAWSTMWNVTDETAINCKR 564
            .|:..:.:.....::..:.|...:...:.:..|.......:||..::...           ||..
 Worm   572 FYIFFSASFCDTKKESTYYGCTYIALLLISSEKQNSNCWYWDDANDLLME-----------NCSN 625

  Fly   565 FLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVFARLLDSLS 625
            :|.. .:.::.|.|.|.....::|:...|    :..:.|   .|.|   |.::.|.:..:|
 Worm   626 YLPS-SIAHYYKHLITLDFLHDILKTTKG----IGLILW---ALST---IRIYLRSISKIS 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	6/29 (21%)
		leucine-rich repeat	136..167	CDD:275381	9/31 (29%)
		leucine-rich repeat	168..189	CDD:275381	7/24 (29%)
		LRR	<184..>282	CDD:443914	20/112 (18%)
		leucine-rich repeat	190..213	CDD:275381	4/22 (18%)
F53G2.1	NP_494284.1	LRR	27..>263	CDD:443914	43/206 (21%)