DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12084 and F53G2.1

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_494284.1	Gene:	F53G2.1 / 186184	WormBaseID:	WBGene00018766	Length:	714	Species:	Caenorhabditis elegans

Alignment Length:	711	Identity:	133/711 - (18%)
Similarity:	243/711 - (34%)	Gaps:	218/711 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LKEIAYQKLC-NNLDIISSHRPDGQRGLNPGIVLPNEICDGFLENYQRFNRPLDDSVIRLFEDTH 83
            |::...:.|| .||..|:|...|.|:.:|        ||  :|.:|.            |.||:.
Worm    78 LQKSCLKSLCLGNLKNIASFFEDDQKSIN--------IC--YLLSYY------------LNEDSR 120

  Fly    84 RT-------------------------SLKIVNLRNST---------------LSSIGLETLMRH 108
            |.                         ||..:::|..|               |.|:.:......
Worm   121 RNLQTLDLSGKEEFSTGWTVKIGHMFPSLTTLSIRGRTLYKKEFLVVCQNFPKLISLDISDTNVQ 185

  Fly   109 KLFALS-LWYCDMISVGSHHLLAHYG----DSLRSLE-LGISSHLLQYAEPNEKEPVDFQLTCPH 167
            .||.:| |.:...:::.:...|:|:.    ..|..|| |.||...|.......::.||..:...:
Worm   186 LLFGISYLIHLRELTMQNLTFLSHFVWLDLFHLSGLEFLDISRDKLNKDMKTVRQYVDCGMGLSN 250

  Fly   168 LRRLVLNGVVMHHR----LQFAHLHDLGHLDLTSCVLANFSLEALGSLPNLHTLIL------FNV 222
            ||.|..:|..:..:    ||.:| ..|..:.:...||...::::.|.: .|:|..|      .|.
Worm   251 LRFLDCSGTDIDDQLVQCLQLSH-PKLKQICVFDSVLQRSTIQSAGMM-TLNTATLGSSLNCLNY 313

  Fly   223 WPIANQLHAIC-CLRRLCTLDISISSSGNGHGTYDLPDQTLEMLMDNLRHLTHLD--------IS 278
            :....:.:|:. ||:.:           |.| .|:..|       |.|.|...::        .|
Worm   314 FVARRKEYAVWKCLKEI-----------NTH-VYNTKD-------DELNHTNFINCTLRAMNTFS 359

  Fly   279 GTNLAGNGVATKESTTTSGMQQSPKMEQHFAL-------TDIPGLASRTQRPLQFLGLYHTAHWA 336
            ..|:...|:......:.....:.|.:|:..||       .|:|.|.|     |..|| :|.|.|
Worm   360 SKNVGDEGIRCLVQISMQETMKMPILERSLALKRLSNFIVDLPSLDS-----LDRLG-FHVAVW- 417

  Fly   337 CKRHDIPALEVAGDANEQQILTAARYYHDRPVLLTRVLNDLYHLFRFENCKDIHTALDVVLSAMD 401
                             |.:..          ||:...||       .:|:.|.      |:||.
Worm   418 -----------------QAVFN----------LLSNFPND-------SDCEKIW------LAAMG 442

  Fly   402 RHLKFKHMQI---SGSATLFYI---VKGRDRSKFGALLRNHIIRTL------LNGMEMHITDDTM 454
             .|:..|:.:   :|..|:.::   :..:|:....|..|.|:::..      ||..|.::|...|
Worm   443 -FLQKNHISVYCQTGVLTVLHMCTTIMTQDQLSLFAEKRPHMLQLFLALNWSLNKKEHNLTRCIM 506

  Fly   455 LRNGYLTLTQFHMP--------VDVLFEYER----------LIKILLHGVSKTEQE--GFVQRIA 499
            ....|||.:.:...        |.||.:..|          .:.::::.....|.:  |...|:.
Worm   507 HIIHYLTKSSYEACKYLEGINFVSVLLDCMRSFNNDQINVQCLAVMVNLARHLEYKCFGIKMRLD 571

  Fly   500 IYLLNTLACQVDGRQKLFLGELGVVSTMFTLIKDRLTRSVFDDVMEVAWSTMWNVTDETAINCKR 564
            .|:..:.:.....::..:.|...:...:.:..|.......:||..::...           ||..
Worm   572 FYIFFSASFCDTKKESTYYGCTYIALLLISSEKQNSNCWYWDDANDLLME-----------NCSN 625

  Fly   565 FLDGRGMEYFLKCLHTFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVFARLLDSLS 625
            :|.. .:.::.|.|.|.....::|:...|    :..:.|   .|.|   |.::.|.:..:|
Worm   626 YLPS-SIAHYYKHLITLDFLHDILKTTKG----IGLILW---ALST---IRIYLRSISKIS 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	6/29 (21%)
		leucine-rich repeat	136..167	CDD:275381	9/31 (29%)
		leucine-rich repeat	168..189	CDD:275381	7/24 (29%)
		leucine-rich repeat	190..213	CDD:275381	4/22 (18%)
		ARM	535..628	CDD:237987	16/91 (18%)
F53G2.1	NP_494284.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810