DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12084 and F44E5.2

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_496512.2	Gene:	F44E5.2 / 185735	WormBaseID:	WBGene00009689	Length:	489	Species:	Caenorhabditis elegans

Alignment Length:	481	Identity:	97/481 - (20%)
Similarity:	179/481 - (37%)	Gaps:	156/481 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 KLFALSLW----YCDMIS------------VGSHHLLAHYGDSLRSLELGISSHLLQYAEPNEKE 157
            ||.||.:.    ||..||            |.:.|:.....:.:.||.:|....:.|..:.:::.
Worm    38 KLVALDIELDPNYCLQISRKLNITKAVCKNVTTEHIKLLSNNCILSLTIGNIDKVKQVYQDDKEN 102

  Fly   158 PVDFQLTCPHLRRLVLNGVVMHHRLQFAHLHDLGHLDLTSCVLANFSL-EALG-SLPNLHTLILF 220
            |:      .::.|| |..|:.....|     :|.:||:....|.:::. :||| .||:|.|||:.
Worm   103 PI------INIARL-LEDVLGEESRQ-----NLQYLDIQGNELFSYNWPKALGHMLPSLQTLIVC 155

  Fly   221 NVWPIANQLHAIC-CLRRLCTLDISISSSGNGHG------------------TYDLPDQTLEM-- 264
            ....|.::...:| ....|..||||.::.||..|                  :||...:..|:
Worm   156 QRSFINDEFSQLCNSFPNLHKLDISDTNIGNLSGISNLKNLQKLCMMNLEFESYDDIKELFEVKS 220

  Fly   265 -----------------------LMDNLRHLTHLDISGTNLAGNGVATKESTTTSGMQQS-PKME 305
                                   |.:.|..|..||.||||:      .|||.:|  :|.| |.::
Worm   221 LRVLNISRDRKDFKPSLIMQYIQLKEVLPELRFLDCSGTNV------DKESIST--IQNSHPNLK 277

  Fly   306 QHFALTDIPGLASRTQRPLQFLGLYHTAHWACKRHDIPALEVAGDANEQQILTAARYY----HDR 366
            :..||.: ||                      |...:|.:::....:....|....:|    ||
Worm   278 KVAALCE-PG----------------------KNFIVPEIKILNSIDLGSTLKCLEHYTTLKHD- 318

  Fly   367 PVLLTRVLNDLYHL----FRFEN--CKDIHTALDVVLSAMDRHLKFKHMQISGSATLFYIVKGRD 425
             |.:::.|:.|::.    :..:|  .:.::.|::...|        .::||.|.|.|..|||...
Worm   319 -VFMSQCLHALFNFIKSSYHIDNEWIQYVYRAINTCSS--------DNVQIQGGACLSLIVKKSI 374

  Fly   426 RSK-------FGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILL 483
            ::.       ...:.:..:.:|..|..:.:..|.|:|....::|              .::|.:.
Worm   375 KTMRPYEVALSRVVCKGSVAKTFYNASKPNSWDLTVLERKVVSL--------------EVLKPIA 425

  Fly   484 HGVSKTEQEGFVQRIAIYLLNTLACQ 509
            :|:...:         :.::|.|.|:
Worm   426 YGIIVRD---------MCMINILNCK 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	9/40 (23%)
		leucine-rich repeat	136..167	CDD:275381	5/30 (17%)
		leucine-rich repeat	168..189	CDD:275381	5/20 (25%)
		leucine-rich repeat	190..213	CDD:275381	8/24 (33%)
		ARM	535..628	CDD:237987
F44E5.2	NP_496512.2	leucine-rich repeat	123..148	CDD:275380	8/24 (33%)
		leucine-rich repeat	149..173	CDD:275380	6/23 (26%)
		LRR_4	172..215	CDD:289563	10/42 (24%)
		leucine-rich repeat	174..195	CDD:275380	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810