DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12084 and zer-1

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_741089.2	Gene:	zer-1 / 175249	WormBaseID:	WBGene00020762	Length:	895	Species:	Caenorhabditis elegans

Alignment Length:	851	Identity:	280/851 - (32%)
Similarity:	414/851 - (48%)	Gaps:	146/851 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PLTLKEIAYQKLCNNLDIISSHRPDGQRGLNPGIVLPNEICDGFLENYQRFNRPLDDSVIRLFED 81
            |:.|.:..:.:..|..: |.:|.|.....|.|....|..         .:.|..:...|.|::.|
Worm    38 PVPLSQELFARFRNKWN-IHNHGPAPVEHLGPPTDEPRP---------DQGNIDMIKQVFRIWSD 92

  Fly    82 THRTSLKIVNLRNSTLSS----------------------IGLETLMRHKLFALSLWY------- 117
            :.|..|:.:||..:|:..                      .|:..|....|:|.|..:
Worm    93 STRLPLEKLNLTGATVDDQIFVDLLHAHAHSITELDLTNVTGVTDLSNAYLYARSTHFPMLTSIR 157

  Fly   118 ---CDMIS--------------------VGSHHLLAHYGDSLRSLELGISSHLLQYAEP----NE 155
               .|:::                    :|...|....|...|.   |:.|.|...::|    ::
Worm   158 MTSMDLVTGHQPRRKNGIASTEFRALFMLGEEALAEARGQMERD---GLRSPLSPSSQPSSIQSD 219

  Fly   156 KEPVDFQLTC-------------PHLRRLVL-----NGVVMHHRLQFAH---------LHDLGHL 193
            .:.:|..:.|             |:::||.|     ....:....|..|         |..|..|
Worm   220 HQSLDALVPCDSPVEPPLITARAPNVKRLFLPRCPAKRTTIDEEEQNTHVILTKILSPLQQLEVL 284

  Fly   194 DLTSCVLANFSLEALGSLPN-LHTLILFNVWPIANQLHAICCLRRLCTLDISISSSGNGHGTYDL 257
            ||:.....: .:..|..|.| |..|||::|..:.:.:..||.:..|..||  :|.|....|.|..
Worm   285 DLSYWSKTD-DMRCLQPLSNTLTCLILYDVPDLYHAVPNICHMTELRILD--VSQSNRDSGLYPH 346

  Fly   258 PDQTLEMLMDNLRHLTHLDISGTNLAGNGVATKESTTTSGMQQSPKMEQHFALTDIPGLASRTQR 322
            |..||..|:.:|::|||||||.||||          |......:|...:....|||.||.|.. |
Worm   347 PVTTLNKLIVSLKYLTHLDISSTNLA----------TQPSSHDNPARYRESVRTDICGLQSLV-R 400

  Fly   323 PLQFLGLYHTAHWACKRHDIPALEVAGDANEQQILTAARYYHDRPVLLTRVLNDLYHLFRFENCK 387
            ||::|||:: ...|....:|||..|:|||||.|::|:.:.|.||..||..|||:.|.|:||.|..
Worm   401 PLKYLGLFN-CESASHVREIPAEVVSGDANEDQVITSLQMYKDRAGLLQNVLNESYQLYRFGNSN 464

  Fly   388 DI--HT-ALDVVLSAMDRHLKFKHMQISGSATLFYIVKGRDRSKFGALLRNHIIRTLLNGMEMHI 449
            .:  || ||.:||.||.|||....:||:|||:||||::..|.::.   .:..::..||:|||:|:
Worm   465 PLTRHTEALHLVLEAMHRHLADSTLQIAGSASLFYIIRKVDMNRD---TKRRVVSALLSGMEVHM 526

  Fly   450 TDDTMLRNGYLTLTQFHMPVDVLFEYERLIKILLHGVSKTEQEGFVQRIAIYLLNTLACQVDGRQ 514
            .:..|:||..|:|.||.:|.|:||:|.||..:|:..:.....:...|||.::|||::||.|:|.|
Worm   527 EEQVMVRNCCLSLCQFEIPQDILFDYSRLAVLLVSVLQHHNADNLTQRIVVFLLNSMACHVEGDQ 591

  Fly   515 KLFLGELGVVSTMFTLIKDRLTRSVFDDVMEVAWSTMWNVTDETAINCKRFLDGRGMEYFLKCLH 579
            |:.:|..|.:..:...|..:.|.:|.||||||.||.:||:||||.:||:.||:..|::.|.||..
Worm   592 KVQVGSYGAIEMILDQIARKHTANVCDDVMEVGWSFLWNITDETPVNCELFLNANGLDLFQKCYE 656

  Fly   580 TFPDRDELLRNMMGLLGNVAEVKWLRPKLMTQEFIEVFARLLDSLSDGIEVGGASASVVARVRER 644
            .|....||:||||||:||:|||..||.:||..:::::|..||:|..:.||
Worm   657 AFKTERELVRNMMGLIGNIAEVDELRSQLMKDDYVKIFCALLESQEESIE--------------- 706

  Fly   645 EMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIKTPSREHVLERMVAAIQRWNIKSERNINYR 709
                         :|||:||||||:.|||.:.|...|..|..|::|:|.|...|.:.:.|.||||
Worm   707 -------------ISYNSAGVLAHMVSDGEEVWKQMTVCRNEVMQRIVEATSSWKLATRRFINYR 758

  Fly   710 SFEPILSLVRCYETPQCQHWAVWALANLTQVYPEKYCKLVEQENGIQILNELIEHESPYCEIKRI 774
            ||.|||.|:..|.....||||||||||||....||||..|..|.|:.:|.||:.:.....:|:.:
Worm   759 SFRPILRLLPLYHAYASQHWAVWALANLTTTDGEKYCAYVRDEGGVPLLEELVSNAITTTDIRTL 823

  Fly   775 ARLVIE 780
            |..|:|
Worm   824 ANTVLE 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	7/54 (13%)
		leucine-rich repeat	136..167	CDD:275381	7/47 (15%)
		leucine-rich repeat	168..189	CDD:275381	6/34 (18%)
		leucine-rich repeat	190..213	CDD:275381	6/22 (27%)
		ARM	535..628	CDD:237987	46/92 (50%)
zer-1	NP_741089.2	leucine-rich repeat	98..123	CDD:275381	4/24 (17%)
		leucine-rich repeat	124..152	CDD:275381	5/27 (19%)
		ARM	594..720	CDD:237987	60/153 (39%)
		ARM	691..831	CDD:237987	64/167 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160715
Domainoid	1	1.000	407	1.000	Domainoid score	I356
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4621
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1066
Isobase	1	0.950	-	0	Normalized mean entropy	S5080
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120457at33208
OrthoFinder	1	1.000	-	-		FOG0006960
OrthoInspector	1	1.000	-	-		oto17239
orthoMCL	1	0.900	-	-		OOG6_107901
Panther	1	1.100	-	-	LDO	PTHR12904
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2960
SonicParanoid	1	1.000	-	-		X5052
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.880