DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12084 and zyg-11

DIOPT Version :9

Sequence 1:	NP_612112.1	Gene:	CG12084 / 192509	FlyBaseID:	FBgn0043458	Length:	793	Species:	Drosophila melanogaster
Sequence 2:	NP_495677.1	Gene:	zyg-11 / 174284	WormBaseID:	WBGene00006996	Length:	799	Species:	Caenorhabditis elegans

Alignment Length:	816	Identity:	174/816 - (21%)
Similarity:	331/816 - (40%)	Gaps:	150/816 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 CDGFLENYQRFNRPLDDSVIRLFEDTHRTSLKIVNLRNSTLSSIGLETLMRHKLFALSLWYCDMI 121
            |...:....|..:.|:...::....|.|..:..::|..:.:....||......|.:..|...|..
Worm    46 CSNDIFEVLRQKKKLNHQTLQTMCSTSRFQINKIDLMGNKVELQDLELCSNQNLVSFRLGDIDYF 110

  Fly   122 SVGSHHLLAHYGDS---------LRSLELG----ISSHLLQYAEPNEKEPVDFQLTCPHLRRLVL 173
            ...:...:|...|:         ||.|:|.    |:|:...|....          .|.|..|..
Worm   111 PNTNKIQVADVLDTALNRTSRQQLRHLDLSGRHRITSNWPTYVARK----------LPRLESLAF 165

  Fly   174 -NGVVMHHRLQ--FAHLHDLGHLDLTSCVLANFSLEALGSLPNLHTLILFNVWPIANQL-HAICC 234
             |....:..|.  .|.|.:|..||::|..:.:.|  .:.||.||..||::|:..:...: ..:..
Worm   166 ANRSTANETLSQIGASLLNLRFLDISSTCVTDIS--CISSLRNLEVLIMYNLNILKGDVTETLSN 228

  Fly   235 LRRLCTLDIS--------ISSSGNGH-----GTYDLPDQTLEM-LMDNLRHLTHLDISGTNLAGN 285
            |.:|..||||        ..:|.:.|     |.|:...:.:|. .......|..:|:||.::...
Worm   229 LTKLRVLDISRKVNTDYLQETSQDAHLDLALGIYNRSVEAIESGTATPWAELRAIDMSGLSIVQF 293

  Fly   286 GVATKESTTTSGMQQSPKMEQHFALTDIPGLASRTQRPLQFLGLYHTAHWACKRHDIPALEVAGD 350
            |.....:.....::..||:|| .:|...|..:|..:.|              .|:    |:|...
Worm   294 GTDRALAFVEKIIEAHPKLEQ-ISLLATPLDSSLIEIP--------------NRN----LQVINT 339

  Fly   351 ANEQQILTAARYYH--DRPVLLTRVLNDLYHLF-----RFENCKDIHTALDVVLSAMDRHLKFKH 408
            .:.:.|:.|..:|.  |||..:|..|:.:|:..     :|.. :::...|.:|..:|.:.|....
Worm   340 VSRRSIIFALSHYANLDRPAFITHALHSVYYQLQSGYDKFSQ-EELKECLRLVCISMQQGLNTLP 403

  Fly   409 MQISGSATLFYIVKGRDRSKFGALLRNHIIRTLLNGMEMHITDDTMLRNGYLTL-TQFHMPVDVL 472
            :||:|||.|:::.|.:...:......|:.|...|:..|.:.:...:.:|.:||: ..:.:.:|.:
Worm   404 VQIAGSACLYHLCKMKRIKRLSVKEVNNCIERSLDAAEQYRSMTQLQKNVWLTICNDYLLHLDEI 468

  Fly   473 FEYERLIKILLHGVSKTEQEGFVQRIAIYLLNTLACQVDGRQKLFLGELGVVST----MFTLIKD 533
             ::.|..|:.| ......::..|:|:.|.:::.:.      .|:...|..:::|    ::.|:|
Worm   469 -DFYRTCKVAL-DTMLLNRDASVERMTIAIVSIVT------PKMRPSEAKILTTETKYVYHLVK- 524

  Fly   534 RLTRSVFDDVMEV----------------------AWSTMWNVTDETAINCKRFLDGRGMEYFLK 576
                 :.:|.:|.                      ..|.:||:|||....||.|||..|::...:
Worm   525 -----IMNDYLEAYTREHRVGHERDNENALYTLKFTLSALWNLTDECPATCKAFLDAGGVQIAFR 584

  Fly   577 CLHTFPDRDELLRNMMGLLGNVAEVKWLR-PKLMTQEFIEVFARLLDSLSDGIEVGGASASVVAR 640
            .|..|.....:...::|:|.|:|||:.|. .:|...|:|.|....||         |:...|.::
Worm   585 ILKAFDYHGNVQTKVLGILNNLAEVEELHLGQLCKNEYISVLISCLD---------GSFNEVDSK 640

  Fly   641 VREREMASANHAYLRFQVSYNAAGVLAHIASDGADAWTIKTPSREHVLERMVAAIQRWNIKSERN 705
            .|.||:          :.||.|||:||::.:: .|.|..:. .|:...|:::..|:::.......
Worm   641 GRYREV----------ERSYFAAGILANLLTN-TDGWESEN-QRDEACEKLLELIEQYPTLPSAM 693

  Fly   706 INYRSFEPILSLVRCYETPQCQHWAVWALANLTQ--------VYPEKYCKLVEQENGIQILNELI 762
            ::|:||.|...:||...:.....|.:|.:.::.|        .|.:.|.::. .::|:..:.|.:
Worm   694 VSYKSFIPFSRIVRESNSNGAIMWCLWGVHHVLQHREKNKAPTYEKGYIEMF-MDSGLSPIVEDM 757

  Fly   763 EH-ESPY-----CEIKRIARLVIE--QCDSGSERMV 790
            .| .|.:     ..:..:||.:|:  .|.|.|...|
Worm   758 SHGHSKHIHNLDIRVVHLAREIIDIVSCHSLSSSPV 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12084	NP_612112.1	leucine-rich repeat	110..135	CDD:275381	4/24 (17%)
		leucine-rich repeat	136..167	CDD:275381	7/34 (21%)
		leucine-rich repeat	168..189	CDD:275381	6/23 (26%)
		leucine-rich repeat	190..213	CDD:275381	7/22 (32%)
		ARM	535..628	CDD:237987	29/115 (25%)
zyg-11	NP_495677.1	leucine-rich repeat	99..131	CDD:275380	5/31 (16%)
		leucine-rich repeat	134..159	CDD:275381	7/34 (21%)
		LRR_RI	<153..238	CDD:238064	23/96 (24%)
		leucine-rich repeat	160..184	CDD:275381	6/23 (26%)
		leucine-rich repeat	185..206	CDD:275381	7/22 (32%)
		leucine-rich repeat	207..231	CDD:275381	5/23 (22%)
		ARM	551..659	CDD:237987	39/126 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820