Protein Alignment Ndf and GLYR1

DIOPT Version :9

• Sequence 1: NP_001188767.1
• Gene: Ndf / 192507
• FlyBaseID: FBgn0043456
• Length: 603
• Species: Drosophila melanogaster
• Sequence 2: XP_016879275.2
• Gene: GLYR1 / 84656
• HGNCID: 24434
• Length: 602
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 191/587 - (32%)
• Similarity: 302/587 - (51%)
• Gaps: 61/587 - (10%)

  Fly    24 DLIWAKMKGFTPWPGMIVDPPLDLLSQQRRANTKCVF--FFGSRNFAWIEENNIKPFEGPWKEEL 86
            ||:|.|:..:.||||.||:||.||   ::....||.|  |||:.:.|||:...:||:.. .|||:
Human    60 DLVWGKLGRYPPWPGKIVNPPKDL---KKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHA-HKEEM 120

  Fly    87 AKVSKPAAFRHAMTDIEKYIDDPAEVDEQVNKSCGAPNHATEADFDKIR--DGLDSEEIVGEEAT 149
            .|::|...|:.|:..:|:::......|:..:.:.....:...:..::.|  .|.:..::...|..
Human   121 IKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGK 185

  Fly   150 ADGNNGVVAHVV--GSPDEGDGLDVEINADSSASPVTSPAVTTKAAGKRTPKAKSVAATSVKSTK 212
            ...|.|.....|  ||.:.|           |.||:       |.|.:::|:           .:
Human   186 VKKNMGEGKKRVSSGSSERG-----------SKSPL-------KRAQEQSPR-----------KR 221

  Fly   213 GSAKSAQKRRTSAQQSP-----SGPSNAKRGKRDVSGEALQDADEASSTPTGRRRVETDALLASI 272
            |.....:|..|..:.|.     :||..|.:.:...| |.::|||.           .....|.|.
Human   222 GRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTAS-EPVKDADP-----------HFHHFLLSQ 274

  Fly   273 AAKRAPNAIALLDRPVVTRPEAQVIDMSSRSNTLADRDIVPSEQTFGFLGLGMMGSTIVKDLIYT 337
            ..|.|....|:..:..:...|.....:.:..:|..:..|.|:::..||||||:|||.||.:|:..
Human   275 TEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKM 339

  Fly   338 GHKVVVWNRTIDKCQPFAEAGAEVKDTPMDVVEAADVIFCCVSDPKGAKDLVFGNCGVLQ-LKDL 401
            ||.|.|||||.:||..|.:.||.:..||.:||...|:.|.||||||.||| |.|..|||| ::.
Human   340 GHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKD-VLGPSGVLQGIRP- 402

  Fly   402 NNKAYVEMSTIDPDTSLDIGEGIKQCNGRYLEAQIHGSRQEAAEGMLIILAGGDRSVFEECHSCF 466
             .|.||:|||:|.||..::.:.|....||:|||.:.|::|.:.:|||:|||.|||.::|:|.|||
Human   403 -GKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCF 466

  Fly   467 KTIAKNTFFLGTDIGNACKVNLILQTILGVSLVGLAEALALADRFSISLNDIIDIFDLTSMKSPM 531
            :.:.|.:|||| ::|||.|:.||:..:.|..:..:||.|.||.....|...::||.:...:.|..
Human   467 QAMGKTSFFLG-EVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIF 530

  Fly   532 LLAKGKEMAKGDFNPQQPLSHMQRDLRLVLNMAENLDQSMPVTSITNEVFKHTKRLGYSEHDSSA 596
            |..|.:.:.:|:|.|...|.::|:||||.:.:.:.::...|:.:..|||:|..|.|..|::|.||
Human   531 LDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSA 595

  Fly   597 VF 598
            |:
Human   596 VY 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndf	NP_001188767.1	N_Pac_NP60	20..106	CDD:99897	33/83 (40%)
		NAD_binding_2	316..477	CDD:281445	80/161 (50%)
		MmsB	319..597	CDD:224995	119/278 (43%)
		NAD_binding_11	481..597	CDD:291499	37/115 (32%)
GLYR1	XP_016879275.2	N_Pac_NP60	56..140	CDD:99897	33/83 (40%)
		DUF4603	137..>223	CDD:317743	17/114 (15%)
		NAD_bind_amino_acid_DH	<260..>352	CDD:330244	32/102 (31%)
		MmsB	318..600	CDD:224995	121/284 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156353
Domainoid	1	1.000	164	1.000	Domainoid score	I3950
eggNOG	1	0.900	-	-		E1_COG2084
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12525
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2728
Isobase	1	0.950	-	0	Normalized mean entropy	S6039
OMA	1	1.010	-	-		QHG45921
OrthoDB	1	1.010	-	-		D379125at33208
OrthoFinder	1	1.000	-	-		FOG0002426
OrthoInspector	1	1.000	-	-		oto88897
orthoMCL	1	0.900	-	-		OOG6_100977
Panther	1	1.100	-	-	LDO	PTHR43580
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4589
SonicParanoid	1	1.000	-	-		X4119
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750