DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ndf and PSIP1

DIOPT Version :9

Sequence 1:	NP_001188767.1	Gene:	Ndf / 192507	FlyBaseID:	FBgn0043456	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_001121689.1	Gene:	PSIP1 / 11168	HGNCID:	9527	Length:	530	Species:	Homo sapiens

Alignment Length:	282	Identity:	65/282 - (23%)
Similarity:	112/282 - (39%)	Gaps:	63/282 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 YKPKDLIWAKMKGFTPWPGMI-------VDPPLDLLSQQRRANTKCVFFFGSRNFAWIEENNIKP 77
            :||.|||:|||||:..||..:       |.||.:.|.         :||||:...|::...:|.|
Human     5 FKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLP---------IFFFGTHETAFLGPKDIFP 60

  Fly    78 FEGPWKEELAKVSKPAAFRHAMTDIE-----KYIDDPAEVDEQVNKSCGAPNHATEADFDKIRDG 137
            :... ||:..|.:|...|...:.:|:     |:....|...:.        |.:::.:.::....
Human    61 YSEN-KEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQS--------NASSDVEVEEKETS 116

  Fly   138 LDSEEIVGEEATADGNNGVVAHVVGSPDEGDGLDVEINADSSASPVTSPAVTTKAAG---KRTPK 199
            :..|:...||..:  |..|...|..:..:......:..|:.......:..|||..|.   |.:||
Human   117 VSKEDTDHEEKAS--NEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPK 179

  Fly   200 AKSVAATSVKSTK--GSAKSAQ----------------KRRTSAQQSPSGPSNAKRGKRDVSGEA 246
            ....|||.||..|  |..|..:                |::...::.|.     |:.|:|..|:
Human   180 RGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPK-----KQPKKDEEGQ- 238

  Fly   247 LQDADEASSTP---TGRRRVET 265
             ::.|:....|   .|::.||:
Human   239 -KEEDKPRKEPDKKEGKKEVES 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndf	NP_001188767.1	N_Pac_NP60	20..106	CDD:99897	30/97 (31%)
		NAD_binding_2	316..477	CDD:281445
		MmsB	319..597	CDD:224995
		NAD_binding_11	481..597	CDD:291499
PSIP1	NP_001121689.1	HDGF_related	3..87	CDD:99895	29/91 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	88..349		36/189 (19%)
		PTZ00121	<89..525	CDD:173412	36/188 (19%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:15797927	146..156		1/9 (11%)
		Integrase-binding domain (IBD). /evidence=ECO:0000269\|PubMed:15895093	340..417
		LEDGF	349..442	CDD:402877
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910