DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ndf and HIBADH

DIOPT Version :9

Sequence 1:	NP_001188767.1	Gene:	Ndf / 192507	FlyBaseID:	FBgn0043456	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_689953.1	Gene:	HIBADH / 11112	HGNCID:	4907	Length:	336	Species:	Homo sapiens

Alignment Length:	354	Identity:	88/354 - (24%)
Similarity:	154/354 - (43%)	Gaps:	50/354 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 LLASIAAKRAPNAIALLDRPVVTRPEA-QVIDMSSRSNTLADRDIVPSEQTFGFLGLGMMGSTIV 331
            :.||:....|.:.:....|.:  ||.| ....:.|||        |.|:...||:|||.||:.:.
Human     1 MAASLRLLGAASGLRYWSRRL--RPAAGSFAAVCSRS--------VASKTPVGFIGLGNMGNPMA 55

  Fly   332 KDLIYTGHKVVVWNRTIDKCQPFAEAGAEVKDTPMDVVEAADVIFCCVSDPKGAKDLVFGNCGVL 396
            |:|:..|:.:::::...|.|:.|.:||.:|..:|.||.|.||.|...:.....|.:...|..|:|
Human    56 KNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGIL 120

  Fly   397 QLKDLNNKAYVEMSTIDPDTSLDIGEGIKQCNGRYLEAQIHGSRQEAAEGMLIILAGGDRSVFEE 461
            : |.......::.|||||..|.::.:.:::....:::|.:.|....|..|.|..:.||....|..
Human   121 K-KVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEFAA 184

  Fly   462 CHSCFKTIAKNTFFLGTDIGNACKVNLILQTILGVSLVGLAEALALADRFSISLNDIIDIFDLTS 526
            .......:..|..:.|. :|......:....:|.:|::|.|||:.|..|..:
Human   185 AQELLGCMGSNVVYCGA-VGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGL------------- 235

  Fly   527 MKSPMLLAKGKEMAKG------DFNPQQ------PLSH----------MQRDLRLVLNMAENLDQ 569
              .|.||||...|:.|      .:||..      |.::          |.:||.|..:.|.:...
Human   236 --DPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSATSTKS 298

  Fly   570 SMPVTSITNEVFKHTKRLGYSEHDSSAVF 598
            .:.:.|:.:::::.....|||:.|.|:||
Human   299 PILLGSLAHQIYRMMCAKGYSKKDFSSVF 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndf	NP_001188767.1	N_Pac_NP60	20..106	CDD:99897
		NAD_binding_2	316..477	CDD:281445	43/160 (27%)
		MmsB	319..597	CDD:224995	74/299 (25%)
		NAD_binding_11	481..597	CDD:291499	30/137 (22%)
HIBADH	NP_689953.1	HIBADH	44..331	CDD:130753	75/301 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810