DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ndf and Psip1

DIOPT Version :9

Sequence 1:	NP_001188767.1	Gene:	Ndf / 192507	FlyBaseID:	FBgn0043456	Length:	603	Species:	Drosophila melanogaster
Sequence 2:	NP_598709.1	Gene:	Psip1 / 101739	MGIID:	2142116	Length:	528	Species:	Mus musculus

Alignment Length:	274	Identity:	66/274 - (24%)
Similarity:	108/274 - (39%)	Gaps:	48/274 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 YKPKDLIWAKMKGFTPWPGMI-------VDPPLDLLSQQRRANTKCVFFFGSRNFAWIEENNIKP 77
            :||.|||:|||||:..||..:       |.||.:.|.         :||||:...|::...:|.|
Mouse     5 FKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLP---------IFFFGTHETAFLGPKDIFP 60

  Fly    78 FEGPWKEELAKVSKPAAFRHAMTDIE-----KYIDDPAEVDEQVNKSCGAPNHATEADFDKIRDG 137
            :... ||:..|.:|...|...:.:|:     |:....|.. :|.|.|........|.:..|  :.
Mouse    61 YSEN-KEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAST-KQSNASSDVEVEEKETNVSK--ED 121

  Fly   138 LDSEEIVGEEATADGNNGVVAHVVGSPDEGDGLDVEINADSSASPVTSPAVTTKAAGKRTPKAKS 202
            .|.||....|   |....|......:...|.....|...|:..:.:.:.|..:..  |.:||...
Mouse   122 TDQEEKASNE---DVTKAVDITTPKAARRGRKRKAEKQVDTEEAGMVTAATASNV--KASPKRGR 181

  Fly   203 VAATSVKSTK--GSAKSAQK-----------RRTSAQQSPSGPSNAKRGKRDVSGEALQDADEAS 254
            .|||.||..|  |..|..::           ...|.::.|......|:.|::..|:  ::.::..
Mouse   182 PAATEVKIPKPRGRPKVVKQPCPSDGDMVIDEDKSKKKGPEEKQPKKQLKKEEEGQ--KEEEKPR 244

  Fly   255 STP---TGRRRVET 265
            ..|   .|::.||:
Mouse   245 KEPDKKEGKKEVES 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ndf	NP_001188767.1	N_Pac_NP60	20..106	CDD:99897	30/97 (31%)
		NAD_binding_2	316..477	CDD:281445
		MmsB	319..597	CDD:224995
		NAD_binding_11	481..597	CDD:291499
Psip1	NP_598709.1	HDGF_related	3..87	CDD:99895	29/91 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..348		43/209 (21%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O75475	146..156		2/9 (22%)
		Integrase-binding domain (IBD). /evidence=ECO:0000250\|UniProtKB:O75475	338..415
		LEDGF	347..448	CDD:288344
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..528
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910