DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptpn1 and PTP-ER

DIOPT Version :9

Sequence 1:NP_035331.3 Gene:Ptpn1 / 19246 MGIID:97805 Length:432 Species:Mus musculus
Sequence 2:NP_726092.1 Gene:PTP-ER / 37461 FlyBaseID:FBgn0016641 Length:1377 Species:Drosophila melanogaster


Alignment Length:478 Identity:88/478 - (18%)
Similarity:146/478 - (30%) Gaps:226/478 - (47%)


- Green bases have known domain annotations that are detailed below.


Mouse    19 IYQDIRHEASDFPCKVAKLPK---NKNRNRYRDVSPFDHSRIKLHQEDND--------------- 65
            |::|:..|..|.|....:.|.   ::.:|||:.:.|.::||:.|..|.::               
  Fly   891 IFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVT 955

Mouse    66 ------YINASLIK-MEEAQRSYILTQGPLPNTCGHFWEMVWEQKSR------------------ 105
                  ||||:.|| .:...:.|:.||||||||...||.|:::...|                  
  Fly   956 ASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDR 1020

Mouse   106 ---------GVVMLNRIMEKGSLKCAQYWPQQEEKEMV-----------------FD-------- 136
                     .:|||....|....|||.|:|.:..:...                 ||        
  Fly  1021 EQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFV 1085

Mouse   137 -DT--------------------GLKLTLISEDVK------SYYTVRQLELENLTTKETREIL-- 172
             ||                    .:|:||..:.::      |::.::.:.:........|:::  
  Fly  1086 PDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLL 1150

Mouse   173 -------------------HFHYTTWPDFGVPESPASFLNFLFKVRESGSLSLEHG--------- 209
                               |:.|..|||...|....:.|:....|...|....|..         
  Fly  1151 YCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSER 1215

Mouse   210 ---------------------PI-VVHCSAGIGRSGTFCLADTCLL------------------- 233
                                 |: |:||||||||:|.|    |.:|                   
  Fly  1216 NAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCF----TAILNAVRQLRQSLAYSLTGMLT 1276

Mouse   234 -------------------------------LMDKR-----KDPSS-----------VDIKKVLL 251
                                           ::|.|     |.|.|           ||:..::.
  Fly  1277 KSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVC 1341

Mouse   252 EMRRFRMGLIQTADQLRFSYLAV 274
            .:|..|.|::|.::|....:.|:
  Fly  1342 NLRLQRGGMVQNSEQYELIHRAI 1364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptpn1NP_035331.3 PTPc 3..276 CDD:214550 88/478 (18%)
PTPc 43..276 CDD:238006 82/451 (18%)
Substrate binding. /evidence=ECO:0000250 215..221 5/5 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 297..322
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..399
PTP-ERNP_726092.1 Y_phosphatase 916..1364 CDD:278528 81/451 (18%)
PTPc 917..1364 CDD:238006 81/450 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0789
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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