DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Slc22a25 and CG33233

DIOPT Version :9

Sequence 1:	NP_620263.1	Gene:	Slc22a25 / 192273	RGDID:	621104	Length:	552	Species:	Rattus norvegicus
Sequence 2:	NP_995978.2	Gene:	CG33233 / 2769005	FlyBaseID:	FBgn0053233	Length:	489	Species:	Drosophila melanogaster

Alignment Length:	488	Identity:	106/488 - (21%)
Similarity:	187/488 - (38%)	Gaps:	121/488 - (24%)

- Green bases have known domain annotations that are detailed below.

  Rat   107 SVTEPDTEPCVDGWVYDQSTFLSTIIT--EWDLVCESQSLDSIAKFLFLTGILVGNILYGPLTDR 169
            ||||..|.    |::        .::|  |:|...:.::|  :|..| |.|::...:..|.|.||
  Fly    33 SVTESMTA----GYL--------VVLTSCEFDTSPKEKTL--LANSL-LGGMVASGLFIGFLADR 82

  Rat   170 FGRRLILICASLQMAVTETCAAFAPTFLIYCSLRFLAGISFSTVLTNSALLI-----IEWTRP-- 227
            :||:.::..|.:........:|..|.......:|.:.|...|.|.:.....:     |:| ||
  Fly    83 YGRKFVIRLALVGALSFSVISALMPDLYSLSVIRIIVGTFLSAVASLQVGFLGEFHAIKW-RPIT 146

  Rat   228 -----KFQALATGLLLCAGAIGQTVL-------AGLAFTVRNWHHLHLAMSVPIFFLLVPTRWLS 280
                 :.|.||  |:.|. .:...:|       ...::.:|.|..|.:...:|.:..||....:.
  Fly   147 VAICSQSQGLA--LIYCP-LVAMAILPNNFNVDLSSSYNLRVWRFLMMFFMIPGWLALVGICLVP 208

  Rat   281 ESARWLIMTNKLQKGLKELIKVAHINGMKNSTDVLTIEVVRTIMKEELEASQTKSSLWD------ 339
            |:..:|:..|:..|.|..|..:..:|..|       .|.|...:.||..::..:...|.
  Fly   209 ETPHFLMSVNRPDKALLALKWICRMNRKK-------WEDVDITLSEEKSSTNDQEGFWKTVWYEY 266

  Rat   340 --LFRTPNLRKRICLLSLVRFVVWLSVIGLLINFQHLR-------------IN---VFL------ 380
              ||..|::.|....|.|: |.::.:.|||.|.|..:|             :|   .|:
  Fly   267 KLLFSKPHVFKFFICLFLI-FGIFFTSIGLGIWFPVIRNMDNSGSNRLCDLVNNNPTFINHEADD 330

  Rat   381 --------------LQCLLGIITIPANLVGIF-----LVNHLGRR--ISQLFIIS-LFGISILAI 423
                          :..|:..:......:|.|     ||:.:.|:  |:...:|| :.||| |.|
  Fly   331 TNGTDSESPKCNDEMTNLIDPVYYGFTYIGCFILASVLVHWMTRKYVIALHILISMILGIS-LNI 394

  Rat   424 IFVPQEMQILRMVLATFGGVFSFVSVSSALVHANELLPTIIRATALGVI-------GIAGSTGAA 481
            :..|..:.|..:::....||. ....:|.||   :.||..:|..||.::       |:.|||...
  Fly   395 MKQPTVVLIFFVLMMVLPGVL-IPLATSVLV---DCLPVNLRGKALCMVRSLARFGGVLGSTMIG 455

  Rat   482 LSPLFMILRTYSDSLPWIIYGVLSFLGGLVVLL 514
            |     .:|...|    :.:.:.:....:.|:|
  Fly   456 L-----FIRVTCD----VTFNIFNLCLAICVVL 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc22a25	NP_620263.1	2A0119	11..525	CDD:273328	106/488 (22%)
		Aldolase_II	39..>85	CDD:294146
		MFS	125..506	CDD:119392	98/460 (21%)
CG33233	NP_995978.2	MFS_1	22..451	CDD:284993	98/449 (22%)
		MFS	23..>208	CDD:119392	43/193 (22%)
		MFS	354..>482	CDD:304372	34/140 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346962
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840