DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptgs2 and cd

DIOPT Version :9

Sequence 1:	NP_035328.2	Gene:	Ptgs2 / 19225	MGIID:	97798	Length:	604	Species:	Mus musculus
Sequence 2:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	562	Identity:	115/562 - (20%)
Similarity:	192/562 - (34%)	Gaps:	153/562 - (27%)

- Green bases have known domain annotations that are detailed below.

Mouse   113 PPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDP 177
            |.||..          |.:.|.....|..||....|. |..:..||.:::|..|:  .|......
  Fly   231 PRTYGA----------SMVPYRRMVSPDYADGIAAPR-VSHHGRLPPARQVSLKI--HRSSYETD 282

Mouse   178 QGSNMMFAFFAQHFTHQFFKT--------------------DH---------------------- 200
            ....:|.|.|.|...|....|                    .|
  Fly   283 SNFTVMLAVFGQFMDHDITATSLTTSQEGESIDCCVAATREQHPECYPVDILPDDPYYKQYNISC 347

Mouse   201 ----KRGPGFTRGLGHGVDLNH---------IYGETLDRQHKLRLFKDGKLKYQVI--GGEVYP- 249
                :..|..|...|..:.||.         :||....||::||.|.:|.|:..|.  |.::.|
  Fly   348 MNFVRSAPAPTGRFGPRMQLNQATAFIDASVVYGNLEQRQNQLRSFINGSLRMFVTDDGRQLLPI 412

Mouse   250 ---PTVKDTQVEMIY---------PPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDIL 302
               |.....:|:|..         .....|||          |:..:.:   :|.|.||.:...|
  Fly   413 SSNPADGCNRVQMTRLGKYCFESGDDRANENL----------LLTSMHL---LWARHHNYLARQL 464

Mouse   303 KQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKL---------------KFDPELL 352
            ::::|.|.||:|:|.:|.||..:...|...:::..|.|.:...               .:|||:
  Fly   465 QEQNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISEAKGLLPAKHNLNAPDTYDPEV- 528

Mouse   353 FNQQFQYQNRIASEF--NTLYHWHPLLPDTFNIE-----DQEYSFKQFLYNN-SILLEHGL---- 405
                   ...||:.|  ......|.|||..|||.     .:.....:.|:|. |:..|||:
  Fly   529 -------DPSIANCFAAAAFRFAHTLLPGLFNISRDNSTPEAIELHKMLFNPFSLWAEHGIDHAL 586

Mouse   406 --------TQFVESFTRQIAGRVAGGR---NVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLK 459
                    .|....|:.::..::..|.   .||:....:...:|.:.|:....|...:|:...|.
  Fly   587 MTAANTPVMQVDRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHCRLP 651

Mouse   460 PYTSFEELTGEKEMAA--ELKALYSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMG 522
            ...::||::...:.|.  .::.:|.....:::|...|.|.|...||||..:..:.:...|:..:|
  Fly   652 TVDTWEEMSQAIDNATLDSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCMVSDQFLRLKLG 716

Mouse   523 NPICSPQYWKPSTFGGEVGFKI----INTASIQSLICNNVKG 560
            :     .:|.....|.:...|.    |...|:.::||.|..|
  Fly   717 D-----SHWYERKMGPQKFTKAQLAEIYKTSLAAIICRNSDG 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptgs2	NP_035328.2	EGF_CA	19..55	CDD:238011
Ptgs2	NP_035328.2	prostaglandin_endoperoxide_synthase	75..562	CDD:188648	115/562 (20%)
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	115/562 (20%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	88/411 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810