DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptgs2 and cysu

DIOPT Version :9

Sequence 1:	NP_035328.2	Gene:	Ptgs2 / 19225	MGIID:	97798	Length:	604	Species:	Mus musculus
Sequence 2:	NP_650627.1	Gene:	cysu / 42100	FlyBaseID:	FBgn0038511	Length:	753	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	147/744 - (19%)
Similarity:	243/744 - (32%)	Gaps:	244/744 - (32%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MLFRAVLL-CAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFLTRIK 64
            |:.|.:|| .||:..:|         ....||.:.|.             :|.:|..
  Fly     1 MILRILLLSLAAVAHAQ---------YHQFGEQLQTA-------------HGSDCAL-------- 35

Mouse    65 LLLKPTPNTVH-YILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYL------------------- 109
            ||..|..::|: |.:..|:|..|..||.|   ...:.|...:.:||
  Fly    36 LLAGPGRSSVYDYNVNLFRGTLNPYNNGP---GTCITYDAINAAYLDARKRIHVAQPKSDWKPEE 97

Mouse   110 ------------IDSPPTYNVHY---------------------------------GYKSWEAF- 128
                        |....||.:.|                                 .|:.::..
  Fly    98 LATVGELLLDISIQLARTYGLSYEEIEKGLPTIDTSKTLIREVCPPFFAGVECRPGKYRRFDGLC 162

Mouse   129 SNLSY---------YTRALPPV-ADDCPTP-MGVKGNKELPDSKEVLEKVLLRREFIPDPQGSNM 182
            :|:.:         :.|.:.|: :|....| :.|.| ::||.|: |:.:.:...:...|..|:.|
  Fly   163 NNIEHPTWGAANAPFQRLIGPLYSDGINAPRISVTG-RDLPFSR-VVSRTMHPDDGFHDHAGTVM 225

Mouse   183 MFAFFAQHFTHQFFKTD-------------------HKRGP----------------------GF 206
            :.| :.|...|.|..|.                   |.:.|                      .|
  Fly   226 VIA-WGQFMDHDFTLTGTPLDPINRNDPEECCKRPLHLKHPYCNEIRIPDDDYFYRLFNVKCIDF 289

Mouse   207 TRG---------LGHG---------VDLNHIYGETLDRQHKLRLFKDGKLK----YQVIGGEVYP 249
            .||         ||..         :|.|.:||.......|||....|.::    :|..|.:...
  Fly   290 VRGFPSPRPGCKLGSRQQFNTLTGVIDANTVYGVKESFARKLRTGYGGLMRMNPVFQEYGLKDLL 354

Mouse   250 PTVKDTQVEMIYPP----HIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWG 310
            |...|...|....|    :..|..:..|.:::.     |....|:..|||||:...|.|.:..|.
  Fly   355 PLKLDIPDEGCTRPNKSMYCFEGGEIRVNEQLV-----LTCMHTLMAREHNRLATALAQINKHWD 414

Mouse   311 DEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFN------- 368
            ||.|||.:|.|.|.....:...:::..|.|.....||.   |..|:..|.:...|..|
  Fly   415 DETLFQEARRINIAIVQHVTFNEFLPILLGKEVMEKFG---LVLQKDGYWDGYDSTVNPGIIDSF 476

Mouse   369 ---TLYHWHPLLPDTFNIEDQEYSF---KQF---------LYNNSILLEH--GLTQFV-----ES 411
               .....|.|||.......:.:.|   |:.         ||...:|.|:  ||...|     :|
  Fly   477 AGAAFRFGHSLLPTAVERWSKAHKFIASKRLSDLIRRPYDLYRAGVLDEYFMGLMNQVAQAMDDS 541

Mouse   412 FTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAE 476
            .|:::...:.........:..|: .::.:.||.......|:||...|....:::|:.|  .|..|
  Fly   542 ITQEVTNHLFKKEGARFGMDLVS-FNMQRGREFGIPGYMEFRKFCGLPTSNTWDEMYG--SMPNE 603

Mouse   477 LKALYSDI-----DVMELYPALLVEKPRPDAIFGET---MVELGAPFSLKGLMGNPICSPQYW-- 531
            ....|..|     |: :|:...:.||..|.::.|.|   ::.....:..:|        .::|
  Fly   604 TVLRYGSIFEHPADI-DLWSGGVSEKSLPGSMLGPTFACVIATQMSYLRRG--------DRFWYE 659

Mouse   532 ---KPSTFGGEVGFKIINTASIQSLICNN 557
               :||:|..| ..:.|..|.:..|||:|
  Fly   660 LPNQPSSFTPE-QLQEIRKAKLSRLICDN 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptgs2	NP_035328.2	EGF_CA	19..55	CDD:238011	4/35 (11%)
Ptgs2	NP_035328.2	prostaglandin_endoperoxide_synthase	75..562	CDD:188648	131/669 (20%)
cysu	NP_650627.1	An_peroxidase	155..692	CDD:281139	117/557 (21%)
cysu	NP_650627.1	peroxinectin_like	305..687	CDD:188655	89/402 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810