DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stab1 and NimB2

DIOPT Version :9

Sequence 1:	NP_619613.2	Gene:	Stab1 / 192187	MGIID:	2178742	Length:	2571	Species:	Mus musculus
Sequence 2:	NP_723857.1	Gene:	NimB2 / 260645	FlyBaseID:	FBgn0028543	Length:	421	Species:	Drosophila melanogaster

Alignment Length:	471	Identity:	103/471 - (21%)
Similarity:	149/471 - (31%)	Gaps:	174/471 - (36%)

- Green bases have known domain annotations that are detailed below.

Mouse  1883 QMKTCSICGLEPPCPRGSREQGSPETCWRHYSKF---WTTPLHSISMRGAYWIPSSFWN-RNHMS 1943
            |.||..|...:||.........|.|:.||.|::.   |:|...|          :..|| :||:.
  Fly    24 QFKTAGIKTRQPPSGNLQLAGNSSESGWRSYNQSSYGWSTQNQS----------NYAWNQQNHVE 78

Mouse  1944 RGCHRNCVTTVWKPSCCP---GHY------------------------------GINCH------ 1969
            :|........|::|...|   |||                              |: |:
  Fly    79 QGSAGFVRAEVFQPVTLPPLYGHYVQPVTPPAHRVQVLDETALFINKTRSAMASGV-CYKEVPTA 142

Mouse  1970 ------------------------ACPGGPRSP---------CSD---HGVCLDGIRGSGQCNCH 1998
                                    .|.|..|:|         |:|   :|:|    .....|.|.
  Fly   143 SLLRNSRDQFVGNGTTPDMSRIQVCCDGYERNPHIYRRCEPICADDCRNGIC----TAPNTCVCI 203

Mouse  1999 PGFAGTA---CELCAPGAFGPQCQACRCTQHGRCDEGLGGSGSCFCDEGWTGARCEVQLELQPVC 2060
            ||...||   |....|...|          :|.|||    ...|.|.||::     ::.|.:..|
  Fly   204 PGHVRTAEGKCISTCPLGCG----------NGVCDE----RNECKCREGYS-----LEPETRKYC 249

Mouse  2061 TPPCAPQAVCRLG-----NSCECSLGYE--GDGRVCTVADLCQKGHGGCSKHANCSQVGTVVTCT 2118
            .|.|.|.  |..|     |.|.|..||.  .||....|.|.|:.|......|.||:.....:...
  Fly   250 QPECKPG--CSFGRCVAPNKCACLDGYRLAADGSCEPVCDSCENGKCTAPGHCNCNAGYLKLQGR 312

Mouse  2119 CLPDYEGDGWSCRARDPCLDGHRGGCSEHADCLNTGPNTRRCECHVGYVGD--GLQCLEELEPPV 2181
            |.|       .|..  ||.:|.         |:  ||:.  |||..|:..|  ..:||.:.:.|
  Fly   313 CEP-------ICSI--PCKNGR---------CI--GPDI--CECASGFEWDRKSAECLPKCDLP- 354

Mouse  2182 DRCLGGSSPCHTDALCTDLHFQEKQAGVFHIQATSGPYGLTFSEAKEACEGQGAVLASLPQLSAA 2246
              ||.|....:....|...:.:::     |.:....|:      ..:.|:..   ..|.|
  Fly   355 --CLNGVCVGNNQCDCKTGYVRDE-----HQRNICQPH------CPQGCQNG---YCSAP----- 398

Mouse  2247 QQLGFHVCFVGWLANG 2262
               .|.:|..|::.:|
  Fly   399 ---NFCICRPGFIKSG 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stab1	NP_619613.2	Fasciclin	520..644	CDD:280607
		EGF_3	915..946	CDD:289699
		EGF_3	952..988	CDD:289699
		Fasciclin	1000..1121	CDD:280607
		EGF_3	1460..1496	CDD:289699
		EGF_3	1502..1539	CDD:289699
		EGF_3	1545..1582	CDD:289699
		Fasciclin	1607..1711	CDD:280607
		Fasciclin	1737..1867	CDD:280607
		EGF_Lam	<1992..2021	CDD:214543	9/31 (29%)
		EGF_3	2095..2130	CDD:289699	7/34 (21%)
		EGF_3	2136..2173	CDD:289699	10/38 (26%)
		Link_Domain	2208..2300	CDD:295393	9/55 (16%)
		FAS1	2367..2463	CDD:214719
NimB2	NP_723857.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900