Protein Alignment Casc3 and btz

DIOPT Version :10

• Sequence 1: NP_619601.2
• Gene: Casc3 / 192160
• MGIID: 2179723
• Length: 698
• Species: Mus musculus
• Sequence 2: NP_001263028.1
• Gene: btz / 43331
• FlyBaseID: FBgn0045862
• Length: 806
• Species: Drosophila melanogaster
• Alignment Length: 757
• Identity: 180/757 - (23%)
• Similarity: 266/757 - (35%)
• Gaps: 218/757 - (28%)

Mouse    63 VESGGAKSAE-ESECESEDGMEGDAVLSDYESAEDSEGEEDYSEEENSKVELKSEANDAADSSAK 126
            ||.|.:.:.| .|.....|        |:|::|.|.||.|||.:||:        |:.:|..|..
  Fly    41 VEPGTSPTQEPNSNSHPHD--------SEYDTASDLEGGEDYDDEES--------ASGSASGSGS 89

Mouse   127 EKGEEKPESKGTVTGERQSGDGQESTE--PVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHD 189
            |:..|..:....|..|...|:|:::.:  ..:::..||      .||||.||.|||::|.|:|||
  Fly    90 EEESETDDEDDEVGSETDDGEGEQAMDRSVADSEAQKK------VDEDRSNPQYIPKRGTFYEHD 148

Mouse   190 LRGQTQEEEV-------------RPKG-----------------------RQRKLWKDEG---RW 215
            .|....|.|:             .|.|                       :..:.|:...   ||
  Fly   149 DRTAETEGEILIEPENGAGQAAAEPNGELNGLAAAGATPTGQTPQISQASKTMRKWQPASGGDRW 213

Mouse   216 EHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSSPQR-DPNWIGDR----- 274
            .||:|...|||||||.||:..||||||:    :|..||..|:.|:...|.: ..||..::
  Fly   214 SHDRFEATEQAPKSRAELLQTYGYDIRN----EDAPPRARRRRRYTRGPSKYSRNWEDEQAYLKA 274

Mouse   275 SSKSHRHQGPGGNLPPR----TFINRNTAGTGRMSASRNYSRSGGFKDGRTSFRPVEVAG----Q 331
            |:|..:        |||    ..:|.......|.|:||..      |:.|   |.|...|    :
  Fly   275 SNKERK--------PPRPQDFPALNERKPRGPRTSSSREE------KENR---RSVAAEGLVPEK 322

Mouse   332 HGGRSAETLKHEASYRSRRLEQTPVRDPSPEPD--APLLGSPEKEEVASETPAAVPDITPPAPDR 394
            ....::.:..|.:..|.|..|:...||..|:..  ..:.|.|.::                   .
  Fly   323 QQPLASSSNPHRSQERERERERERERDREPKNRNFGRMNGGPGRQ-------------------N 368

Mouse   395 PIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLASTATVPETTPAAKTGNWEAPVDSTTGGLEQ 459
            .:|.|..:|.::.|.:.....:.......||...::....|:..|..:               :|
  Fly   369 GMEFKKNNRGQQLRERERGPDQLDNRNQKPSTPRSNQQQQPQQQPHHQ---------------QQ 418

Mouse   460 DVAQLNIAEQSWSPSQP-------SFLQPRELRGVPNHI-----HMGA--GPPPQFNRMEEMGVQ 510
            ...|...::...||..|       ..||..:.|..|:|:     |..|  ...||..:.:.:..:
  Fly   419 PQQQRQPSQPQQSPQTPLSTSNLSQRLQQVQQRNDPSHVGSVQMHSLASQNQAPQQQQQQPLHQE 483

Mouse   511 SGRA-KRYSS---------------------------------QRQRPVPEPPAPPVHISIMEGH 541
            ...| |||||                                 |.|..:.:|     |:.:...:
  Fly   484 QRNAPKRYSSLRRSQQEASQHLAEQQQQQMQQQLHLQQQQQQQQSQIMIQDP-----HVLMQIAY 543

Mouse   542 YYDPLQFQ------GPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPGPLPNPGL--YPPP 598
            ....||.|      ||....|..|.|         |:.|.|....:|.....|....|.  .|.|
  Fly   544 QQQELQAQLQTMQLGPPTAAGAVPTP---------PKPHAPPAAAYPQAQAAPYYVTGTEPVPVP 599

Mouse   599 VSMSPGQPPPQQLLAPTYFSAPGVMNFGNPNYPYAPGALPPPPPPHLYPNTQAPPQVY------G 657
            |..:|...|......||   .|..:.:.....|..  ..|.|||....|.|| |.|.|      |
  Fly   600 VPQAPYVNPASAAYLPT---TPAAVAYAQAGPPVV--TQPTPPPAQAPPATQ-PAQPYQNYNTVG 658

Mouse   658 GVTYY-NPAQQQVQPKPSPPRRTPQPVSIKPPPPEVVSRGSS 698
            |.||: .|||...:|...|.||....:.|.||..:...:|.:
  Fly   659 GTTYFVPPAQTTSRPSALPQRRPTNAIPILPPSEKHKVKGGA 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Casc3	NP_619601.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..229		57/207 (28%)
		Necessary for RNA-binding, interaction with MAGOH and localization in nucleus speckles. /evidence=ECO:0000250	134..280		56/192 (29%)
		Sufficient to form the EJC. /evidence=ECO:0000250	134..280		56/192 (29%)
		Btz	143..245	CDD:214991	44/142 (31%)
		Nuclear localization signal 1. /evidence=ECO:0000255	201..207		2/28 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..457		42/231 (18%)
		Nuclear localization signal 2. /evidence=ECO:0000255	251..259		3/7 (43%)
		PHA03247	<273..698	CDD:223021	104/502 (21%)
		Necessary for localization in cytoplasmic stress granules. /evidence=ECO:0000250	374..698		80/386 (21%)
		Nuclear export signal	457..466		2/8 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..533		15/85 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	575..614		9/40 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	629..698		26/75 (35%)
btz	NP_001263028.1	Btz	102..243	CDD:214991	46/150 (31%)