DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptf1a and HLH4C

DIOPT Version :9

Sequence 1:	NP_061279.2	Gene:	Ptf1a / 19213	MGIID:	1328312	Length:	324	Species:	Mus musculus
Sequence 2:	NP_001259243.1	Gene:	HLH4C / 31397	FlyBaseID:	FBgn0011277	Length:	191	Species:	Drosophila melanogaster

Alignment Length:	199	Identity:	56/199 - (28%)
Similarity:	84/199 - (42%)	Gaps:	47/199 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse    32 SRDPLEDSDELLGDEQAEV---EFLSHQLHEYCYRDGACLLLQPAPSAAPHALAPPPLGDPGEPE 93
            ||..|.|.||::|.....:   ::.:....:...|..|.:..:.|...||    |||
  Fly    19 SRYYLVDDDEMIGPNNPHLVNEDYAASTTLDIDKRFQARMACETAAQPAP----PPP-------- 71

Mouse    94 DNVSYCCDAGAPLAAFPYSPGSPPSCLAYPCAAVLSPGARLGGLNGAAAAAAARRRRRVRSEAEL 158
                               |...|.....|.|. |.|...:|         .:|..||.|..|.|
  Fly    72 -------------------PTPAPRRRTTPIAH-LDPSELVG---------LSREERRRRRRATL 107

Mouse   159 QQLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQADLPLR 223
             :.|.|...|||.|:::.|.:|..||..:||||.:|:|||::.|:|||.||.:|:.:::.  |..
  Fly   108 -KYRTAHATRERIRVEAFNVSFAELRKLLPTLPPDKKLSKIEILKLAICYIAYLNHVLET--PXD 169

Mouse   224 GSGA 227
            .:||
  Fly   170 SAGA 173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptf1a	NP_061279.2	HLH	162..217	CDD:238036	25/54 (46%)
Ptf1a	NP_061279.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..324
HLH4C	NP_001259243.1	HLH	108..165	CDD:238036	25/56 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810