DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pten and aux

DIOPT Version :9

Sequence 1:	NP_032986.1	Gene:	Pten / 19211	MGIID:	109583	Length:	403	Species:	Mus musculus
Sequence 2:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	97/427 - (22%)
Similarity:	160/427 - (37%)	Gaps:	109/427 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 IKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYR-NNIDDVVRFLDSKH-KNHYKI 67
            :::.::||         |||:::|...|:.|..|::..|..|: |||:||...|:|:. .....|
  Fly   403 MQQSLARN---------DLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSI 458

Mouse    68 YNLCAERHYDTAKFNCRVAQ----YPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGK 128
            ||. .:|.........|..:    |.....:.|.|:.:.....|:..:|:.|...|..:......
  Fly   459 YNF-GQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSG 522

Mouse   129 GRT-GVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTI---PSQRRYVYYYSYLLKNHLDYR 189
            |.| ..:|||.|::.....:.::|:..:...|.      ||   ||:.||:||:..:|      |
  Fly   523 GCTAATVICALLMYADLLREPEDAVQVFAVKRH------TINLRPSEFRYLYYFGDIL------R 575

Mouse   190 PVALLFH-------KMMFETIPMFSGGT----------CNPQFVVCQL----KVKIYSSNSGPTR 233
            |..||.|       .:..:.:|..:...          ||...::..|    |:::|.:..|.
  Fly   576 PTPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGK-- 638

Mouse   234 REDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKD--KMFHFWVNTFFIPGPEETSEKVENGSLC 296
                   ...|..|..|||:.|..||.:..|::..  |:..|..||.|||.||
  Fly   639 -------IVLPINLTACGDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPEPE------------ 684

Mouse   297 DQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEE-------- 353
                               .::|.|..|||.....:   ..:|.|.|.|....|..|
  Fly   685 -------------------TLITFTNQDLDDLPDPE---QVTPRFCVSLSLAVTDSESPPSHKPP 727

Mouse   354 --PSNPEASSSTSVTPDVSDNEP-DHYRYSDTTDSDP 387
              |:.|:.|.:...:.|:...|. |::....:|.|.|
  Fly   728 WMPAKPKRSPAALFSSDLEYAEMLDNFVTKPSTRSSP 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pten	NP_032986.1	PTP_PTEN	24..181	CDD:350359	42/166 (25%)
		PTEN_C2	188..349	CDD:402161	39/183 (21%)
		Required for interaction with NOP53. /evidence=ECO:0000250\|UniProtKB:P60484	338..348		4/9 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..403		10/47 (21%)
		PDZ domain-binding. /evidence=ECO:0000250	401..403
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	34/172 (20%)
		DnaJ	<1110..1150	CDD:197617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810