DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptch2 and ptc

DIOPT Version :9

Sequence 1:NP_032984.1 Gene:Ptch2 / 19207 MGIID:1095405 Length:1182 Species:Mus musculus
Sequence 2:NP_523661.2 Gene:ptc / 35851 FlyBaseID:FBgn0003892 Length:1286 Species:Drosophila melanogaster


Alignment Length:1246 Identity:454/1246 - (36%)
Similarity:679/1246 - (54%) Gaps:158/1246 - (12%)


- Green bases have known domain annotations that are detailed below.


Mouse    28 GSLQAPLWLRAYFQGLLFSLGCRIQKHCGKVLFLGLVAFGALALGLRVAVIETDLEQLWVEVGSR 92
            ||..| ::||:.||..|.:||..:|||.|||||:.::......:||:.|.|.:.:.|||::.|.|
  Fly    48 GSRTA-IYLRSVFQSHLETLGSSVQKHAGKVLFVAILVLSTFCVGLKSAQIHSKVHQLWIQEGGR 111

Mouse    93 VSQELHYTKEKLGEEAAYTSQMLIQTAHQEGGNVLTPEALDLHLQAALTASKVQVSLYGKSWDLN 157
            :..||.||::.:||:.:.|.|:||||.|....:||.|:||..||:..:.|:.|:|.||...|.|.
  Fly   112 LEAELAYTQKTIGEDESATHQLLIQTTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTEWGLR 176

Mouse   158 KICYKSGVPLIENGM--IERMIEKLFPCVILTPLDCFWEGAKLQG--GSAYLPG-RPDIQWTNLD 217
            .:|.....|..| |:  ||:::..|.||.|:|||||||||::|.|  .:..:|| ...:.||.|:
  Fly   177 DMCNMPSTPSFE-GIYYIEQILRHLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQRLLWTTLN 240

Mouse   218 P--------QQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLDPDDPHCPPSAPNRHSRQAPN 274
            |        |::.||...| ..|...:.:.:|.:|..|:.:|||:|.:|:||.:|||::|.|.|:
  Fly   241 PASVMQYMKQKMSEEKISF-DFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPD 304

Mouse   275 VAQELSGGCHGFSHKFMHWQEELLLGGTARDLQGQLLRAEALQSTFLLMSPRQLYEHFRGDYQTH 339
            |...|||||:|::.|.|||.|||::||..|:..|.|.:|:||||...||:.:::|:.::.:|:.|
  Fly   305 VGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVH 369

Mouse   340 DIGWSEEQASMVLQAWQRRFVQLAQEALPANA----SQQIHAFSSTTLDDILRAFSEVSTTRVVG 400
            .:||::|:|:.||.||||.|.:..::.|...:    :..|:.|||..|||||..||..|...:|.
  Fly   370 HLGWTQEKAAEVLNAWQRNFSREVEQLLRKQSRIATNYDIYVFSSAALDDILAKFSHPSALSIVI 434

Mouse   401 GYLLMLAYACVTMLRW-DCAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLAL 464
            |..:.:.||..|:||| |..:.|.:||:|||||:..:.|:||||.|||||.||||:|||:|||||
  Fly   435 GVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLAL 499

Mouse   465 GIGVDDIFLLAHAFTKAPPDTPLPERMGECLRSTGTSVALTSVNNMVAFFMAALVPIPALRAFSL 529
            |:|||.||:|..|:.    ::...|:....|:..|.|:..::.:...:||.||.:|:|||:.|.|
  Fly   500 GLGVDHIFMLTAAYA----ESNRREQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCL 560

Mouse   530 QAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLCCF-----SSPCSAQVIQMLPQELGDRAV 589
            |||||:..|.||.:|||||::|||||||...|.|:.||.     ..|..|..:..|....|..| 
  Fly   561 QAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCCCFPVWKEQPKVAPPVLPLNNNNGRGA- 624

Mouse   590 PVGIAHLTATVQAFTHCEASSQHVVTILPPQAHLLSPASDPLGSELYSPGGSTRDLLSQEEGTGP 654
                          .|.::.:.:.|.:         ||.:||..:.....||:..|         
  Fly   625 --------------RHPKSCNNNRVPL---------PAQNPLLEQRADIPGSSHSL--------- 657

Mouse   655 QAACRPLLCAHWTLAHFARYQFAPLLLQTRAKALVLLFFGALLGLSLYGATLVQDGLALTDVVPR 719
                     |.::||.||...:.|.|:::..|.|.::.|.|.|..|||.:|.:||||.:.|:||:
  Fly   658 ---------ASFSLATFAFQHYTPFLMRSWVKFLTVMGFLAALISSLYASTRLQDGLDIIDLVPK 713

Mouse   720 GTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHY 784
            .:.||.||.||.|.|..|.:..||||.|:|...|:.|.|.|..|..:..|:.......|..||..
  Fly   714 DSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLL 778

Mouse   785 YRSWLQGIQAAFDQDWASGRIT--CHSYRNGSEDGALAYKLLIQTGNAQEPLDFSQLTTRKLVDK 847
            :..||..:|..||:::..||:|  |. :.|.|.|..|||||::|||:...|:|...:.|.:||:.
  Fly   779 FSEWLGNLQKIFDEEYRDGRLTKECW-FPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNS 842

Mouse   848 EGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLH--DKYDTTGENLRIPAAQPLEFAQF 910
            :|:|....||..|:.|.::|.....|||...||.|.::.|  ::||     |:||.:.||.:||.
  Fly   843 DGIINQRAFYNYLSAWATNDVFAYGASQGKLYPEPRQYFHQPNEYD-----LKIPKSLPLVYAQM 902

Mouse   911 PFLLHGLQKTADFVEAIEGARAACTEAGQAGVHAYPSGSPFLFWEQYLGLRRCF-LLAVCILLVC 974
            ||.||||..|:.....|...|....:....|:..||||.||:|||||:.||... ::..|:||..
  Fly   903 PFYLHGLTDTSQIKTLIGHIRDLSVKYEGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAA 967

Mouse   975 TFLVCALLLLSPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASIGIGVEFTVHVALG 1039
            ..|| :|||||.|.|.|::|.:.....::||.|..|||||||||.|||:.|:|:.:.|.|.::||
  Fly   968 LVLV-SLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLG 1031

Mouse  1040 FLTSHGSRNLRAASALEQTFAPVTDGAVSTLLGLLMLAGSNFDFIIRYFFVVLTVLTLLGLLHGL 1104
            |:||.|:|..|...:::.:..|:..|.:::.:.:.||:.|.|:|:||:|..:|.|:..:|..:.|
  Fly  1032 FMTSVGNRQRRVQLSMQMSLGPLVHGMLTSGVAVFMLSTSPFEFVIRHFCWLLLVVLCVGACNSL 1096

Mouse  1105 LLLPVLLSILGPPPQVVQVYKESPQTLNSAAP--------------------QRGGLRWD----- 1144
            |:.|:|||::||..::|.:  |.|..:::.:|                    .||..:..     
  Fly  1097 LVFPILLSMVGPEAELVPL--EHPDRISTPSPLPVRSSKRSGKSYVVQGSRSSRGSCQKSHHHHH 1159

Mouse  1145 ---RPPTL------PQSFARVTTSMTV---------------------ALH-------------- 1165
               ..|:|      |||:....:|:.:                     |.|              
  Fly  1160 KDLNDPSLTTITEEPQSWKSSNSSIQMPNDWTYQPREQRPASYAAPPPAYHKAAAQQHHQHQGPP 1224

Mouse  1166 ---PPPLPGAY 1173
               |||.|.||
  Fly  1225 TTPPPPFPTAY 1235

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptch2NP_032984.1 2A060602 12..1142 CDD:273338 440/1161 (38%)
Sterol-sensing 418..570 CDD:289145 76/156 (49%)
7TM-7TMR_HD 961..1085 CDD:285000 49/124 (40%)
ptcNP_523661.2 2A060602 17..1134 CDD:273338 438/1143 (38%)
MMPL 454..598 CDD:304422 74/147 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845390
Domainoid 1 1.000 297 1.000 Domainoid score I1459
eggNOG 1 0.900 - - E1_KOG1935
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 854 1.000 Inparanoid score I430
Isobase 1 0.950 - 0 Normalized mean entropy S4544
OMA 1 1.010 - - QHG49297
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003078
OrthoInspector 1 1.000 - - otm43252
orthoMCL 1 0.900 - - OOG6_105508
Panther 1 1.100 - - O PTHR46022
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2737
SonicParanoid 1 1.000 - - X2446
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.740

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