DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment old-2 and btl

DIOPT Version :9

Sequence 1:	NP_496123.1	Gene:	old-2 / 191738	WormBaseID:	WBGene00003863	Length:	498	Species:	Caenorhabditis elegans
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	329	Identity:	122/329 - (37%)
Similarity:	181/329 - (55%)	Gaps:	37/329 - (11%)

- Green bases have known domain annotations that are detailed below.

Worm   163 EINEEDLDISKGRPLGSGEFGII----RKGFLRSKNSKNKETESRLEVAVKSPLNEYNHIQQELI 223
            ||..:.|  |.|..||.|.||.:    .:|..||...      :...||||....|:.......:
  Fly   706 EIPRQQL--SLGSILGEGAFGRVVMAEAEGLPRSPQL------AETIVAVKMVKEEHTDTDMASL 762

Worm   224 YDELKVMCAVGKHPNILALVGGITIGEKRMIISELVENGDLLSFLRKN------RRNFTIDQLAF 282
            ..|::||..:|||.||:.|:|..:.|....:|.|...:|:|..||::|      ||:   |...:
  Fly   763 VREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRS---DSDGY 824

Worm   283 EPEKP-----SLGLVDLVSFAFQIAKGMEYLIHVPCVHRDLALRNVLIKGNMVIRIADFGLARRH 342
            ..:||     .||..:|..||||||:|||||....|:|||||.||||:....|::||||||||..
  Fly   825 LDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDI 889

Worm   343 KNKDYYKTQSVDTPLPIHWMAPESIDKLLFTQKSDVWSYGVCLYELFSLGKSPYKNVIKYDERDS 407
            ::.:||: ::.:..|||.||||||:.:..:..:||||||||.|:|:.:.|..||.:::..:|
  Fly   890 QDTEYYR-KNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEE--- 950

Worm   408 YCKYVLAYLNEGKRLAQPAHADAEIYNVMKLCWDLDMNSRTTFLDCIEFFEKELKTTS---NEYF 469
                :.:||..|:|:.:||.....||.||:.||..:..:|.||.:.:|.|:..|:..|   |:.:
  Fly   951 ----LYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAY 1011

Worm   470 LDLT 473
            |||:
  Fly  1012 LDLS 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
old-2	NP_496123.1	PTKc	175..458	CDD:270623	110/297 (37%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352
		IGc2	408..469	CDD:197706
		IG_like	492..583	CDD:214653
		Ig	507..583	CDD:299845
		PKc_like	700..1000	CDD:304357	116/312 (37%)
		TyrKc	712..996	CDD:197581	113/302 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810