DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gcy-25 and Gyc76C

DIOPT Version :9

Sequence 1:	NP_001294116.1	Gene:	gcy-25 / 191653	WormBaseID:	WBGene00001549	Length:	1034	Species:	Caenorhabditis elegans
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	1057	Identity:	269/1057 - (25%)
Similarity:	468/1057 - (44%)	Gaps:	229/1057 - (21%)

- Green bases have known domain annotations that are detailed below.

Worm    83 ETQTVSRLALRWHKLYLSSAPLSTKEKESTTIALKPHSLAGTAEVILAMCKSMKWKEIGIIYSEE 147
            :::.:..::.:..:...|:.|...:.:...|..:|.         :||:.:...|.:..|:|.:.
  Fly   113 QSRNIPMISYKCAEYRASAIPTFARTEPPDTQVVKS---------LLALLRYYAWNKFSILYEDV 168

Worm   148 TKYTAHAIYDMLAEQ--EDDLKIN---VFLE------------------------TDGLSNTYTI 183
            ....|    |:|.:|  :.::.||   .|::                        |...:..|..
  Fly   169 WSPVA----DLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVF 229

Worm   184 LHSARALISFLTTLDLSKFFKTLKENAFRPLEFSIVHVDC---NKSEISNF------YTYLDN-N 238
            |.:|.:|:.|:::::.:        ..|...|:.::.||.   ::.|...:      .|::.| :
  Fly   230 LGAANSLVDFMSSMETA--------GLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCH 286

Worm   239 AGEEPNPISAARLRKLYRHVALLKNSHDDMEKTEEFAKKYGLVPSYTL----------------Y 287
            :.|..|.::.:.|     .||....:.|.::.|:: .:||...|.:.|                .
  Fly   287 STENFNQMARSLL-----VVASTPPTKDYIQFTKQ-VQKYSSKPPFNLEIPRLFVESNFSKFISI 345

Worm   288 KALILCDGLQL--------------------------------------------------LNNY 302
            .|..|.|.::|                                                  ::.|
  Fly   346 YAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQY 410

Worm   303 TAPRGNLSIVQQLPYLWNHVTNTETQGYSGPVFIGNDGVRLPYYEMHM----WRDGKAVHVANVK 363
            ....||.|::...|:.||:..|.....:..||...:.|...|.|::..    |..|      ..|
  Fly   411 GDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSG------GEK 469

Worm   364 PRESDYCGGNMTKNCYEFLPSSPLLEDLPPYTSDCGYDNNLC--SDFH-VFMIAAIVFSILL--- 422
            |.:                  .|:          ||:.|.||  .|.| ...:||:|..:||
  Fly   470 PAD------------------EPM----------CGFANELCKKDDTHYTSTVAAVVLGVLLFCS 506

Worm   423 --IPMAIAFYLQRKEHL-IQQMPWRVPLDSISFDDNGGSLSASRRVSTISTARASYSS------I 478
              |.|:|  |.:.|..| |:.:.|::..:.|........:|:..:||.:|.  .||.|      :
  Fly   507 GVITMSI--YRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSA--QSYGSRWTNQFV 567

Worm   479 FSGNVAEHAIV--NKQKVSVKRHVQRRAITFSRQEMEMLNQLKYMSHTNINPFTGICFNQGSELI 541
            .|......|:|  .:.|...||.:.|..:    :||.:|.:|:   |.|||.|.|... :.:.::
  Fly   568 TSTGRLRGAVVRIKELKFPRKRDISREIM----KEMRLLRELR---HDNINSFIGASV-EPTRIL 624

Worm   542 VMWQFTTRYSLEDLIFVKEQKFGRNFQSTFIKHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVV 606
            ::..:..:.||.|:|..::.|....|.::.|..::.|:.|||||.:..||.|..|||||.|.|::
  Fly   625 LVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWML 689

Worm   607 KLTDFGIKGILKERTNHKELAPSSAFDVDAIHYK-YLQLAPE----HISAILEKLEEPRGTVEGD 666
            ::||||:.. |::...::.:....       ||: .|..|||    ||          .|:.:||
  Fly   690 QVTDFGLHE-LRQCAENESIGEHQ-------HYRNQLWRAPELLRNHI----------HGSQKGD 736

Worm   667 IYQLAMCIYQILFYMRPFAERQESIKELAHL---LSSQSTAPLHPKVP---EGNSFTMRLLSIIQ 725
            :|..|:.:|:|.....||.:.....||:...   |..:...|..|:|.   |..|....:|:.|:
  Fly   737 VYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIR 801

Worm   726 QCWLYKPAARPALIKITDAVNREFGQDVKGTLIDQMIEMIDEYSANLEQIVAERTRELEQDMSVT 790
            .||...|..||....|.:.:.:..|...| .::|||:||:::|:.|||.||.||||.|.::...|
  Fly   802 DCWAEDPEERPEFSVIRNRLKKMRGGKTK-NIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKT 865

Worm   791 ENLLYQLLPKSVADSIRSGKTVVPEQHSSVTLLVVDVCQFTKFCEAFIPVHILETLQELYSSFDN 855
            |:||:::||:|||:.:..|:.|.|..:..||:...|:..||.......|:.::..|.:||:.||.
  Fly   866 EDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDR 930

Worm   856 IVQKNKAFKVENVGDAYLICSGIPEMSGFRHLREICKISLKLQAFMKTFKVRHRPSHTLQIKMGI 920
            |::....:|||.:||||::.||:|..:|.||..||..::|:|...:|..::.|||:.||::::|:
  Fly   931 IIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGM 995

Worm   921 TSGAVAAGILGSTAPRFCIFGDTVNMACRMASTGNPGSIQLSELTANTLMEKFPSFMLEERGMID 985
            .:|.|.||::|.|.||:|:||||||.|.||.|.|....|.:|......|.:....::.|:||:::
  Fly   996 HTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVN 1060

Worm   986 VKGKGACLTFWLTGEKD 1002
            :||||..:|:||||..:
  Fly  1061 MKGKGDVVTWWLTGANE 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcy-25	NP_001294116.1	PBP1_iGluR_N_LIVBP_like	56..>230	CDD:107346	27/178 (15%)
		PKc_like	473..746	CDD:304357	81/291 (28%)
		SPS1	474..>736	CDD:223589	78/280 (28%)
		HNOBA	<764..805	CDD:285003	21/40 (53%)
		CYCc	790..976	CDD:214485	71/185 (38%)
		Nucleotidyl_cyc_III	812..999	CDD:299850	71/186 (38%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	54/358 (15%)
		ANF_receptor	48..412	CDD:279440	45/325 (14%)
		PK_GC-A_B	543..827	CDD:270944	85/311 (27%)
		HNOBA	<835..881	CDD:285003	24/45 (53%)
		CYCc	860..1052	CDD:214485	71/191 (37%)
		Guanylate_cyc	887..1074	CDD:278633	71/186 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910