DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gcy-19 and Gyc76C

DIOPT Version :9

Sequence 1:	NP_001348702.1	Gene:	gcy-19 / 191650	WormBaseID:	WBGene00001544	Length:	1187	Species:	Caenorhabditis elegans
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	1223	Identity:	368/1223 - (30%)
Similarity:	570/1223 - (46%)	Gaps:	190/1223 - (15%)

- Green bases have known domain annotations that are detailed below.

Worm    39 ANRRTI-RVGVAAVQTTELDSIGWPMSGGAINMAIQKLRDDGFIAPFDF-EVTVNYTECDRSLGA 101
            :|.||: .||.....|.:|.:.......||:.||:.::..|..:.|..: ::..|.|:.|..| |
  Fly    20 SNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVL-A 83

Worm   102 AVGMEFMRTKRLDVVIGPPCRDPMEIMATMATYYSTPMLGW--------GLVTDSKFTDTERYPY 158
            ...:..|....:..:.||  ..|..:.|.::...:.||:.:        .:.|   |..||  |.
  Fly    84 TKAITEMICDGIATIFGP--EGPCYVEAIVSQSRNIPMISYKCAEYRASAIPT---FARTE--PP 141

Worm   159 LTNIMANSLSLGFSLVKLLEMMEWDRVALVYEESAQDYPLS-VINDVET----AINEYDTFAVNV 218
            .|.::.       ||:.||....|::.:::||:...  |:: ::.|..|    .||...:|..|.
  Fly   142 DTQVVK-------SLLALLRYYAWNKFSILYEDVWS--PVADLLKDQATKRNMTINHKQSFIDNR 197

Worm   219 V--VKQALPGGDLNDAQYISVLNRIKLRCRIIVSVFQTAPTRRRYLKMIDQQGM-ANEEYVHILL 280
            |  .:|.|  .......:..::.....|.||.| ....|.:...::..::..|: |..||:.|.:
  Fly   198 VKCCEQML--DCCRSGYWYQLVQNTMNRTRIYV-FLGAANSLVDFMSSMETAGLFARGEYMVIFV 259

Worm   281 GLRSIGFGKQSAGLTKCE-----LNCLSSGLAPFWDIAPDDGLNDRLKQAATRMLVM-DLPDTMD 339
            .:......:....|.:.:     .||.|:               :...|.|..:||: ..|.|.|
  Fly   260 DMMVYSEREAEKYLRRVDQITFMSNCHST---------------ENFNQMARSLLVVASTPPTKD 309

Worm   340 LSTDVPDINYLNTFTMNCGAVVVNPPVSCATPACINASTSPP--SAFARSLHDVFYLYGLAITNL 402
                     |:. ||.........||.:...|.....|....  |.:|..|:|...||..|:..:
  Fly   310 ---------YIQ-FTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKM 364

Worm   403 YNQDPAYLNDIDKI-----NGALQLN-------FAGLTG-EVSINANNSRVPKLMLYALN-DKYD 453
            ..::...|.| |.|     ||...::       :..:|| ::.|:..........:.|.. .|::
  Fly   365 LREETRVLTD-DVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWN 428

Worm   454 QASFMNLTYSLNGGASVSLAYTNE-----------ASLWYWYGGKRPLSVPVCGFAGTDCPQSFV 507
            .::.|...|.:     |.:||.::           .|:.:..||::|...|:||||...|.:...
  Fly   429 NSNNMPCNYHM-----VPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDT 488

Worm   508 DQYGALVFAIGGVLIFAMLFVITCFFYVMRQKRLERDRIDAEWQIPLVKLQAPPKRDKERMSKRS 572
            .....:...:.|||:|.. .|||...|  |:.::|.:.....|:|...:::.        .|...
  Fly   489 HYTSTVAAVVLGVLLFCS-GVITMSIY--RKWKIELEIEGLLWKIDPNEIKG--------YSGNE 542

Worm   573 LQSGPSNITDTSKMTFDNTFSNYSIFYLDKEPVLSTAHPASNLIRTDYDTFVR------------ 625
            :.|.||.::..|..::.:.::|        :.|.||......::|.....|.|
  Fly   543 IVSSPSKVSLMSAQSYGSRWTN--------QFVTSTGRLRGAVVRIKELKFPRKRDISREIMKEM 599

Worm   626 --LRKLDHENVNKFVGMSIDGPEYLAVWKLCMRGSLQDIIGQGNFSIDPFFMFCVIRDMAEGLKY 688
              ||:|.|:|:|.|:|.|::....|.|...|.:|||.|||...:..:|..|:..:|.|:.:|:.|
  Fly   600 RLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIY 664

Worm   689 LHNSFLHVHANLRSGTVLVNESWQAKLTDFGLGTL---AEEKK----PMKRRQLWMAPEVIRGTL 746
            :|||.|..|.||:|...:|...|..::|||||..|   ||.:.    ...|.|||.|||::|..:
  Fly   665 IHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHI 729

Worm   747 LPHQIEKSADIYSLAVIASEVLTRKEAWNMA--ERKDTVDEIVYRIKKGGPNAPRPELD--MDGV 807
              |..:| .|:|:.|:|..|:.:||..:...  |.|:.|| .|.::...|.:..|||::  ::..
  Fly   730 --HGSQK-GDVYAFAIIMYEIFSRKGPFGQINFEPKEIVD-YVKKLPLKGEDPFRPEVESIIEAE 790

Worm   808 EINHNLLILIRDCWSEEPADRPSADVICNLLKNMM-PKKGNLMDHVFNILEDYTTNLEVEVEDRT 871
            .....:|..|||||:|:|.:||...||.|.||.|. .|..|:||.:..::|.|..|||..|.:||
  Fly   791 SCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERT 855

Worm   872 KELTAEKKKADVLLGRMLPKQVAERLKQGQTVEPEGFDSVTVFFSDVVKFTQLAAKCSPFQVVNL 936
            :.|..||.|.:.||.||||:.|||:|..||.|||..:|.||::|||:|.||.::|:.:|.||||.
  Fly   856 RLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNF 920

Worm   937 LNDLYSNFDAIIEEHGCYKVESIGDGYLCVSGLPSKNGNAHIKQIVELSLDFMSYCKSFKIPHLP 1001
            |||||:.||.||..:..||||:|||.|:.|||||.|||:.|..:|..::|:.:...|..:|.|.|
  Fly   921 LNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRP 985

Worm  1002 REKVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKASHIHLSAASYTLLMKHYPN 1066
            .|.::||||:::||.|||||||:|||||||||||||||||||||:|..||:| ....|.:.....
  Fly   986 NETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHIS-NKCKLALDKLGG 1049

Worm  1067 QYNTASRGDVIIKGKGVMETFWVFERNNQFMGVSSNSGYQSDKKATNNGSSPESTPPSTPPMHEV 1131
            .|.|..||.|.:||||.:.|:|:       .|.:.|:   ..||..:....|       ||:..
  Fly  1050 GYITEKRGLVNMKGKGDVVTWWL-------TGANENA---IQKKLVDMMDMP-------PPLFS- 1096

Worm  1132 KANSPVRHRKPPSPSSPTLSKRSVSPIMEAKARDIHNEETEALYRQFRRQETL 1184
                  |.||     ||.|:..|..|.::|    :|...|.:     |||.|:
  Fly  1097 ------RPRK-----SPKLNPDSRQPSIQA----MHFCGTGS-----RRQSTV 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcy-19	NP_001348702.1	PBP1_NPR_GC_like	45..467	CDD:107347	93/460 (20%)
		PKc_like	571..841	CDD:328722	94/294 (32%)
		CYCc	876..1065	CDD:214485	105/188 (56%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	95/469 (20%)
		ANF_receptor	48..412	CDD:279440	85/409 (21%)
		PK_GC-A_B	543..827	CDD:270944	95/295 (32%)
		HNOBA	<835..881	CDD:285003	21/45 (47%)
		CYCc	860..1052	CDD:214485	105/192 (55%)
		Guanylate_cyc	887..1074	CDD:278633	101/194 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910