DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gcy-13 and Gyc76C

DIOPT Version :9

Sequence 1:	NP_506097.3	Gene:	gcy-13 / 191646	WormBaseID:	WBGene00001539	Length:	1028	Species:	Caenorhabditis elegans
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	1139	Identity:	355/1139 - (31%)
Similarity:	566/1139 - (49%)	Gaps:	201/1139 - (17%)

- Green bases have known domain annotations that are detailed below.

Worm     4 SVGWQTS-------------ASAIEIAMDRI-KSEHLIDNIGINFIYVFDDCNEAKA-AGLSSKL 53
            :||:.|:             :.|:.:|:|.: |..:|:.|:.::..:     |:.|. ..|::|.
  Fly    27 TVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYLDLRW-----NDTKGDTVLATKA 86

Worm    54 LMDA---NVSAIVGPTCNAAGLAVVNLAGYYNTPVLTWGLTISSSFIDTSKYPTTVTIVPVAKSI 115
            :.:.   .::.|.||.......|:|:.:  .|.|::::    ..:....|..||.....|....:
  Fly    87 ITEMICDGIATIFGPEGPCYVEAIVSQS--RNIPMISY----KCAEYRASAIPTFARTEPPDTQV 145

Worm   116 AAAIHEVMIQFEWTEFVYVFVEDEKCGYFRDDLEQITSD---SNYTSLSRTIQIYDQSYTNLVRQ 177
            ..::..::..:.|.:|..::          :|:....:|   ...|..:.||. :.||:.:
  Fly   146 VKSLLALLRYYAWNKFSILY----------EDVWSPVADLLKDQATKRNMTIN-HKQSFID---- 195

Worm   178 LEKLKTVSRIFTVCLPEAGDIKRRFMLAAYDLDMTTDEYVYLFAGPKSTAYQQTSS--------T 234
             .::|...::...|  .:|   ..:.|....::.|.   :|:|.|..::.....||        .
  Fly   196 -NRVKCCEQMLDCC--RSG---YWYQLVQNTMNRTR---IYVFLGAANSLVDFMSSMETAGLFAR 251

Worm   235 GDVVGIWVD---WSENPDGRDEEA------KLAFM-------------RTMVIVATPVQGEQYAA 277
            |:.:.|:||   :||    |:.|.      ::.||             |::::||:....:.|..
  Fly   252 GEYMVIFVDMMVYSE----REAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQ 312

Worm   278 FKKEVIERMKLPPYNCVDECK----EKEYQE-AAEYADQLHDTIYLYALILNKTIEEQG------ 331
            |.|:|.:....||:|.  |..    |..:.: .:.||..|:|::.|||..::|.:.|:.
  Fly   313 FTKQVQKYSSKPPFNL--EIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDD 375

Worm   332 --IEQIANGSNIV-----------TRGAGIEF------EGMSGVVRMNGIGYRLPNM--NLANLD 375
              .|..:||:.::           ..|:.|:.      ||...|     :.|: |:.  |..|:.
  Fly   376 VIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSV-----LAYK-PHKWNNSNNMP 434

Worm   376 SNATQRTVAYMDIDSTSVNWTFAIIDQALIWDAYNGKLPQTRPECGYSGKSCPVNFFVDYLYIVV 440
            .|.....|||  ......:..:.:|:.::.|.: .|:.|...|.||::.:.|..:   |..|...
  Fly   435 CNYHMVPVAY--FHQGEEHPEYKLINGSIDWPS-GGEKPADEPMCGFANELCKKD---DTHYTST 493

Worm   441 IVAVI--IVLCCAAAAIAAFLVIKARRDEELRLDDQWIVPHGMLQSI----IKG----------R 489
            :.||:  ::|.|:..     :.:...|..::.|:.:     |:|..|    |||          .
  Fly   494 VAAVVLGVLLFCSGV-----ITMSIYRKWKIELEIE-----GLLWKIDPNEIKGYSGNEIVSSPS 548

Worm   490 KESHHSSRSLQSNST----TTTGTTGISSRSVFFPETETQGYFVYMNEPVLARKYQLRVPIFKQD 550
            |.|..|::|..|..|    |:||              ..:|..|.:.|....||..:...|.|
  Fly   549 KVSLMSAQSYGSRWTNQFVTSTG--------------RLRGAVVRIKELKFPRKRDISREIMK-- 597

Worm   551 RSELRMLRSIEHDNVNRFIGLSIDGPVYMSFWRYCSRGSIKDVIAKSSINMDGFFIYCLIKDIAS 615
              |:|:||.:.|||:|.|||.|::....:....||::||:.|:|....|.:|..||..||.|:..
  Fly   598 --EMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIK 660

Worm   616 GLQYIHHSPIKQHGSLTSECCYINDRWQVKIGSYGLSFMQGVEKRTEDG-------LLHTAPEVL 673
            |:.|||:|.:..||:|.|..|.:..||.:::..:||..::...:....|       .|..|||:|
  Fly   661 GMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELL 725

Worm   674 REGLTSGTQAGDVYSFSIVCSELVGHSSAWNLENRKEEADEIIFMVKR---GGRTPFRPSLDDV- 734
            |..: .|:|.||||:|:|:..|:......:...|  .|..||:..||:   .|..||||.::.:
  Fly   726 RNHI-HGSQKGDVYAFAIIMYEIFSRKGPFGQIN--FEPKEIVDYVKKLPLKGEDPFRPEVESII 787

Worm   735 -DDDINPAMLHLIRDCWDEDPKQRPNIDMVNKLMKNMNSGRSGSANLMDHVFSVLEKHASSLEDE 798
             .:.....:|..|||||.|||::||...::...:|.|..|:  :.|:||.:..::||:|::|||.
  Fly   788 EAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGK--TKNIMDQMMEMMEKYANNLEDI 850

Worm   799 VQERMKELVEEKKKSDILLYRMLPQQVAERLKLGQSVEPEAFESVTIFFSDVVGFTVLANKSTPL 863
            |.||.:.|.|||.|::.||:|||||.|||:|.:||.|||.:::.|||:|||:||||.::.:||||
  Fly   851 VTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPL 915

Worm   864 QVVNLLNDLYTTFDAIIEKNDSYKVETIGDAYLVVSGLPRRNGTEHVANIANMSLELMDSLQAFK 928
            ||||.||||||.||.||...|.||||||||||:||||||.:||..|...||:|:|||:.:::..:
  Fly   916 QVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHR 980

Worm   929 IPHLPQEKVQIRIGMHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGKPGFIHLSSDCYDLLT 993
            |.|.|.|.:::|||||:|..|||||||||||||||||||||||||||||:...||:|:.|...|.
  Fly   981 IAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALD 1045

Worm   994 SLYKEYNTESRGEVIIKGKGVMQTYWLLGMKEES 1027
            .|...|.||.||.|.:||||.:.|:||.|..|.:
  Fly  1046 KLGGGYITEKRGLVNMKGKGDVVTWWLTGANENA 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcy-13	NP_506097.3	PBP1_NPR_GC_like	3..397	CDD:107347	90/475 (19%)
		ANF_receptor	13..368	CDD:279440	80/422 (19%)
		PKc_like	548..770	CDD:304357	79/233 (34%)
		HNOBA	<797..829	CDD:285003	19/31 (61%)
		CYCc	808..1000	CDD:214485	119/191 (62%)
		Guanylate_cyc	835..1022	CDD:278633	115/186 (62%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	90/466 (19%)
		ANF_receptor	48..412	CDD:279440	76/404 (19%)
		PK_GC-A_B	543..827	CDD:270944	95/304 (31%)
		HNOBA	<835..881	CDD:285003	24/45 (53%)
		CYCc	860..1052	CDD:214485	119/191 (62%)
		Guanylate_cyc	887..1074	CDD:278633	115/186 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910