DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gcy-6 and Gyc76C

DIOPT Version :9

Sequence 1:	NP_001294696.1	Gene:	gcy-6 / 191644	WormBaseID:	WBGene00001533	Length:	1086	Species:	Caenorhabditis elegans
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	1105	Identity:	343/1105 - (31%)
Similarity:	534/1105 - (48%)	Gaps:	135/1105 - (12%)

- Green bases have known domain annotations that are detailed below.

Worm    55 ASAASIAIDKIKREGLLLG---YDFKFTILYDQCDENIAAGNAIKLFAEHNVDVLFGPTTNNAAM 116
            :.|.::|:|::.::..||.   .|.::.   |...:.:.|..||.......:..:|||..
  Fly    47 SGALTMALDEVNKDPNLLPNVYLDLRWN---DTKGDTVLATKAITEMICDGIATIFGPEG----- 103

Worm   117 PVF---ILATYYNIPLITWGITSSATLDDESRFPTAGMLSIGSRSLAVTFREVMKEYGWDQFVFA 178
            |.:   |::...|||:|::.......    |..||..........:..:...:::.|.|::|...
  Fly   104 PCYVEAIVSQSRNIPMISYKCAEYRA----SAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSIL 164

Worm   179 YSLEMNDEKCETLRDDF--QNMVAYYGDIVLSYAV----QIMDHSEEGL-LAILKDVSTRGRIIV 236
            |. ::.....:.|:|..  :||...:....:...|    |::|....|. ..::::...|.||.|
  Fly   165 YE-DVWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYV 228

Worm   237 PCFHEGNSRGLHRRWMLVAARNGFVNDEYVYIFPSLRSRGYAVPQADGTFRYPWTEATGPQPGDQ 301
               ..|.:..|......:.....|...||:.||..:..  |:..:|:...|..          ||
  Fly   229 ---FLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMV--YSEREAEKYLRRV----------DQ 278

Worm   302 EALLG----------FQKSIFIVDMQGQGNVGSNYTQFEHEIIQRMKEPPYNCTDACASPEYQTA 356
            ...:.          ..:|:.:|   .......:|.||..::.:...:||:|........|...:
  Fly   279 ITFMSNCHSTENFNQMARSLLVV---ASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFS 340

Worm   357 ---ATYAGQLHDSVYIYGVVMDQIMK---------TVPNQYKNGTAFPRKMAGVFNG------VG 403
               :.||..|:|||.:|...:|::::         .:.....|||   |.:..:...      .|
  Fly   341 KFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGT---RVIDTIIKNRTYMSITG 402

Worm   404 GTVAIDEGGGLQPTLFVLTL------DSNN---NSSLIMTVDVDQQEAVVTKHYTNEATALWSHR 459
            ..:.||:.|..:....||..      :|||   |..::......|.|........| .:..|. .
  Fly   403 SKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLIN-GSIDWP-S 465

Worm   460 KGIRPPDQPICGYTGSLCPANVFFQYIGWFIAAIIIIFFTIMGAILAFIYLCHAKQQEVERQNAL 524
            .|.:|.|:|:||:...||..: ...|.....|.::.:.....|.|...||  ...:.|:|.:..|
  Fly   466 GGEKPADEPMCGFANELCKKD-DTHYTSTVAAVVLGVLLFCSGVITMSIY--RKWKIELEIEGLL 527

Worm   525 WQIPFKSMMTVTKKGKGEHSMRSISSVPSTISSTRSST---------LSEVGETRNYLFFQIQND 580
            |:|....:       || :|...|.|.||.:|...:.:         ::..|..|.
  Fly   528 WKIDPNEI-------KG-YSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRG--------- 575

Worm   581 VEMERVAAKKHSIRMVFDNKTCATMRQMRLIDHANLNKFIGMSLDAPQLYSVWRFCSRGSLADVI 645
             .:.|:...|...:.....:....||.:|.:.|.|:|.|||.|::..::..|..:|::|||.|:|
  Fly   576 -AVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDII 639

Worm   646 RKASMQMDGFFIYSLMKDIINGLTWIHESSHEFHGMLTSKNCLLNDRWQLKITDFGLRIFR---- 706
            ....:::|..||.||:.|:|.|:.:||.|...:||.|.|.||::..||.|::|||||...|
  Fly   640 ENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAE 704

Worm   707 -----THDQYNKSDRLWTSPELLRTDDILGSREGDIYSFGIISAELITRSSVFDLENRKEDAEEI 766
                 .|..|.  ::||.:||||| :.|.||::||:|:|.||..|:.:|...|...|  .:.:||
  Fly   705 NESIGEHQHYR--NQLWRAPELLR-NHIHGSQKGDVYAFAIIMYEIFSRKGPFGQIN--FEPKEI 764

Worm   767 IYMLKKGGLQSP---RPSLEHDESIEINP-ALLHLVRDCWTERPSERPDIKQVASQLRSMNTNRN 827
            :..:||..|:..   ||.:|.....|..| .:|..:||||.|.|.|||:...:.::|:.|...:.
  Fly   765 VDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKT 829

Worm   828 DNLMDHVFNVLESYASTLEDEVAERMKELVEEKKKSDVLLYRMLPRQVADKLKLGQTVEPETFDI 892
            .|:||.:..::|.||:.|||.|.||.:.|.|||.|::.||:||||:.||:||.:||.|||.::|:
  Fly   830 KNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDL 894

Worm   893 VTLFFSDVVSFTTLAGKCTPLQVVNLLNGLYTIFDGIIEQHDVYKVETIGDGYFVASGVPRRNGN 957
            ||::|||:|.||.::.:.|||||||.||.|||:||.||..:||||||||||.|.|.||:|.:||:
  Fly   895 VTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGD 959

Worm   958 EHTRNIASMSINFVKSLADFSIPHLPGEKIKIRVGFHCGSVVAGVVGLTMPRYCLFGDAVNTASR 1022
            .|...||||::..:.::....|.|.|.|.:|:|:|.|.|.||||||||||||||||||.||||||
  Fly   960 RHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASR 1024

Worm  1023 MESNSKPGQIHLSEEANQMLMRL-GGFTTEPRGEVIIKGKGVMATYWLLKMDESAAPKILKKKQD 1086
            ||||.:..:||:|.:....|.:| ||:.||.||.|.:||||.:.|:||...:|:|..|.|....|
  Fly  1025 MESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMD 1089

Worm 1087 1086
Fly 1090 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcy-6	NP_001294696.1	PBP1_NPR_GC_like	29..445	CDD:107347	83/439 (19%)
		ANF_receptor	57..424	CDD:279440	77/413 (19%)
		PKc_like	585..822	CDD:304357	88/249 (35%)
		HNOBA	<847..879	CDD:285003	17/31 (55%)
		CYCc	858..1048	CDD:214485	109/190 (57%)
		Guanylate_cyc	885..1070	CDD:278633	105/185 (57%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	81/431 (19%)
		ANF_receptor	48..412	CDD:279440	74/397 (19%)
		PK_GC-A_B	543..827	CDD:270944	96/298 (32%)
		HNOBA	<835..881	CDD:285003	22/45 (49%)
		CYCc	860..1052	CDD:214485	110/191 (58%)
		Guanylate_cyc	887..1074	CDD:278633	106/186 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010