DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gcy-4 and Gyc76C

DIOPT Version :9

Sequence 1:	NP_496218.2	Gene:	gcy-4 / 191642	WormBaseID:	WBGene00001531	Length:	1136	Species:	Caenorhabditis elegans
Sequence 2:	NP_001163473.1	Gene:	Gyc76C / 8674026	FlyBaseID:	FBgn0266136	Length:	1525	Species:	Drosophila melanogaster

Alignment Length:	1175	Identity:	345/1175 - (29%)
Similarity:	552/1175 - (46%)	Gaps:	205/1175 - (17%)

- Green bases have known domain annotations that are detailed below.

Worm    25 RPVIRVG----ITAALKTENGSIGWAYTGGAVPLALQYL-KSHGYMLNFDFEFHVEYTECDLANT 84
            |.|:.||    :|..|||..|    ....||:.:||..: |....:.|...:.....|:.|....
  Fly    23 RTVLTVGYLTALTGDLKTRQG----LAISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLA 83

Worm    85 VRAGLNFMKTNNYDVIIGP--PCAPALKMMGTLSTIYKKPVLGWGFVSESEISDMNRFPFV---- 143
            .:| :..|..:....|.||  ||                      :| |:.:|.....|.:
  Fly    84 TKA-ITEMICDGIATIFGPEGPC----------------------YV-EAIVSQSRNIPMISYKC 124

Worm   144 ----ASVLPS-TKT----LGVVTS--KLLEIYGWDRVALLY----------FKNELDYCSSVVND 187
                ||.:|: .:|    ..||.|  .||..|.|::.::||          .|::....:..:|.
  Fly   125 AEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILYEDVWSPVADLLKDQATKRNMTINH 189

Worm   188 VEKSLYNESKSVQIVMKAEIDGSNSESTSATLQVVKTRARVILFCAHAGGEKRFY--LIQAGLLG 250
            .:..:.|..|..:.:    :|...|......:|....|.|:.:|...|.....|.  :..|||..
  Fly   190 KQSFIDNRVKCCEQM----LDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFA 250

Worm   251 MNSSEYVHVMLSMRSVGFGVQTSVGKKPLTLSGLPPIWESFTVNPDGMEDLAKSVAAKMIVIDTS 315
              ..||:.:.:.|      :..|..:....|..:..|  :|..|....|:. ..:|..::|:.::
  Fly   251 --RGEYMVIFVDM------MVYSEREAEKYLRRVDQI--TFMSNCHSTENF-NQMARSLLVVAST 304

Worm   316 SEVRDKTFLQYMTKNIVYAIREPPLSCKVPECLITN--ATGMGAYARHLFDVFYMYGMAVSSLNS 378
            ...:|  ::|: ||.:.....:||.:.::|...:.:  :..:..||.:|:|...:|..||..:..
  Fly   305 PPTKD--YIQF-TKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLR 366

Worm   379 TDPNVYGNLSLLIPKFTTAFEGMTGEVKLNEDLARKPLY-QVYGLNSEYDQI--SLIDISLI--- 437
            .:..|..:        ...||..:...::.:.:.:...| .:.|...:.||.  |..:.|::
  Fly   367 EETRVLTD--------DVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYK 423

Worm   438 ----NDTVNVVFNY-------------------ADGNTEVWHFW--GGTRPPDTPVCGFLGKSCP 477
                |::.|:..||                   .:|:.:    |  ||.:|.|.|:|||..:.|.
  Fly   424 PHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSID----WPSGGEKPADEPMCGFANELCK 484

Worm   478 LPIFEQYRALVIVAIAVTILILLAIIICMSSKIRNRRVEQSRLHSEWQIHAIKLRLPMHRRASK- 541
            ..  :.:....:.|:.:.:|:..:.:|.||            ::.:|     |:.|.:.....|
  Fly   485 KD--DTHYTSTVAAVVLGVLLFCSGVITMS------------IYRKW-----KIELEIEGLLWKI 530

Worm   542 SSQESETESASETENFTSKSGDTMTSEFKETYTIQYLENDLVLTTAH------QVQELS------ 594
            ...|.:..|.:|..:..||........:...:|     |..|.:|..      :::||.
  Fly   531 DPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWT-----NQFVTSTGRLRGAVVRIKELKFPRKRD 590

Worm   595 -QAEMMKFVK-LRKLDHENLNKFIGLSIDGSRFVSVWKMCSRGSLQDIISKGSFSMDYFFMFCMI 657
             ..|:||.:: ||:|.|:|:|.|||.|::.:|.:.|...|::|||.|||......:|..|:..:|
  Fly   591 ISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLI 655

Worm   658 RDIAEGLHYIHKSFLRHHGNLRSATCLVNDSWQVKLADFGL----QFLQDEE--EKPFKKNMLWA 716
            .|:.:|:.|||.|.|.:||||:|:.|:|...|.:::.||||    |..::|.  |....:|.||.
  Fly   656 HDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWR 720

Worm   717 APEVIRGSLSIEQMDSSADIYSFAIVASEILTKREAWDLSRRKEGYEEIKYA-------VKK--- 771
            |||::|..:...|   ..|:|:|||:..||.:         ||..:.:|.:.       |||
  Fly   721 APELLRNHIHGSQ---KGDVYAFAIIMYEIFS---------RKGPFGQINFEPKEIVDYVKKLPL 773

Worm   772 GGQFVLRPDLHIDIEVNQT---LLALVKDCWCENPEERPSAENVCKVLFDMTPNTEDNLMDHVFS 833
            .|:...||::...||....   :||.::|||.|:|||||....:...|..|......|:||.:..
  Fly   774 KGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMME 838

Worm   834 MLEEYTSSLEVEVGERTKELTLEKKKSDILLGRMLPKQVAERLKAGQAVEPESFDLVTVFFSDLV 898
            |:|:|.::||..|.|||:.|..||.|::.||.||||:.|||:|..||.|||.|:||||::|||:|
  Fly   839 MMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIV 903

Worm   899 KFTDLASKCSPFQVVNLLNDVFSNFDSIIEKHDVYKVESIGDGFLCVSGLPNRNGMEHIRQIVGM 963
            .||.::::.:|.||||.|||:::.||.||..:||||||:|||.::.|||||.:||..|..:|..|
  Fly   904 GFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASM 968

Worm   964 SLCFMEFCRNFRIPHLPRERVELRVGINSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSM 1028
            :|..:...:..||.|.|.|.::||:|:::||.|||||||:|||||||||||||||||||||:...
  Fly   969 ALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALK 1033

Worm  1029 IHMSEAAHSLLVNNYPYQFETNSRGEVIIKGKGVMETYWLLG-------KMSLSNQSTPPITKVN 1086
            ||:|... .|.::.....:.|..||.|.:||||.:.|:||.|       |..:.....||  .:.
  Fly  1034 IHISNKC-KLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPP--PLF 1095

Worm  1087 HKPRK 1091
            .:|||
  Fly  1096 SRPRK 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gcy-4	NP_496218.2	PBP1_NPR_GC_like	29..457	CDD:107347	93/492 (19%)
		ANF_receptor	49..423	CDD:279440	77/406 (19%)
		PKc_like	558..819	CDD:304357	93/293 (32%)
		HNOBA	<834..876	CDD:285003	22/41 (54%)
		CYCc	855..1047	CDD:214485	103/191 (54%)
		Guanylate_cyc	882..1070	CDD:278633	99/187 (53%)
Gyc76C	NP_001163473.1	PBP1_Speract_GC_like	26..445	CDD:107365	92/472 (19%)
		ANF_receptor	48..412	CDD:279440	79/413 (19%)
		PK_GC-A_B	543..827	CDD:270944	94/300 (31%)
		HNOBA	<835..881	CDD:285003	22/45 (49%)
		CYCc	860..1052	CDD:214485	103/192 (54%)
		Guanylate_cyc	887..1074	CDD:278633	99/187 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910