DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrm-2 and scramb1

DIOPT Version :9

Sequence 1:	NP_493321.1	Gene:	scrm-2 / 191509	WormBaseID:	WBGene00014200	Length:	265	Species:	Caenorhabditis elegans
Sequence 2:	NP_648389.3	Gene:	scramb1 / 326186	FlyBaseID:	FBgn0052056	Length:	416	Species:	Drosophila melanogaster

Alignment Length:	239	Identity:	94/239 - (39%)
Similarity:	140/239 - (58%)	Gaps:	6/239 - (2%)

- Green bases have known domain annotations that are detailed below.

Worm    24 PGASIQAAPGAIWMEALPAIEGIPAGLEYLAYLDTVMVHQVKEVLEILTGWESKNKYAIRNKNGQ 88
            ||.:.|..|...||.....|...|.|||||..:|.::|.|..|:||..||:|:.||:.|:|..||
  Fly   171 PGMAPQGGPAGDWMSIPTGIPNCPRGLEYLTTIDQLLVKQKVELLEAFTGFETNNKFTIKNALGQ 235

Worm    89 QCYYAFEESNAWERQCCGSQRGFTMHIVDNFNKNVLIVKRELRCCADSFCGCLLGLQNICTIESL 153
            :.|:|.|:::...|.|||..|.|.|.:.|||.:.|:.:.|.|.|.:..|..||..::    :.:.
  Fly   236 KVYFAAEDNDCCTRNCCGPARPFDMRVFDNFQQEVIHMHRPLACSSCLFPCCLQSIE----VSAP 296

Worm   154 STGLLGTVLQGYGCTNSFYNILDKDGNLIFLVDGQGCCTSCCCEDKDFTIKTPDSSVPIGSITKK 218
            ...::||:.|.:...:..:.||:..|:.:..::|. .||...|.|.:|.:.:. :...||.|:|:
  Fly   297 PGNVIGTIEQEWSICSPSFRILNHVGDTVMRIEGP-FCTFSLCGDVEFNVVSL-TGEKIGKISKQ 359

Worm   219 WGGLLREAFTDADTFAVTFPIDLDVKLKAILLGATFLIDFVEFE 262
            |.||.||.|||||.|.:.||:||||::||:|||||||||.:.||
  Fly   360 WSGLAREIFTDADFFGINFPLDLDVRMKAVLLGATFLIDAMFFE 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrm-2	NP_493321.1	LOR	40..263	CDD:295149	88/223 (39%)
scramb1	NP_648389.3	Sox_C_TAD	<61..>129	CDD:288887
scramb1	NP_648389.3	Scramblase	184..404	CDD:252175	89/226 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	193	1.000	Domainoid score	I1864
eggNOG	1	0.900	-	-		E1_KOG0621
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41418
Inparanoid	1	1.050	208	1.000	Inparanoid score	I2390
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28609
OrthoDB	1	1.010	-	-		D1015148at2759
OrthoFinder	1	1.000	-	-		FOG0000205
OrthoInspector	1	1.000	-	-		mtm4812
orthoMCL	1	0.900	-	-		OOG6_100156
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1891
SonicParanoid	1	1.000	-	-		X164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770