DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EEF1A1 and eRF3

DIOPT Version :9

Sequence 1:	NP_001393.1	Gene:	EEF1A1 / 1915	HGNCID:	3189	Length:	462	Species:	Homo sapiens
Sequence 2:	NP_001260415.1	Gene:	eRF3 / 34658	FlyBaseID:	FBgn0020443	Length:	619	Species:	Drosophila melanogaster

Alignment Length:	448	Identity:	169/448 - (37%)
Similarity:	256/448 - (57%)	Gaps:	29/448 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     4 EKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERE 68
            ::.|:|:|.|||||:||||..|.::...|.:||||:||:|:||.|..:.|:..:|.||..:.||:
  Fly   192 KREHVNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRESWYLSWALDTNQEERD 256

Human    69 RGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQT 133
            :|.|:::....|||.:.:.||:|||||:.|:.|||.|.:|||.|||:::|..||||.|..:.|||
  Fly   257 KGKTVEVGRAFFETDRKHFTILDAPGHKSFVPNMIGGAAQADLAVLVISARKGEFETGFDRGGQT 321

Human   134 REHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNP-DTVAFVPISGWN 197
            ||||:||.|.|||.|:|.|||||.....:.|.||.|...::..|:||:|:|| ..:.|:|.||.:
  Fly   322 REHAMLAKTAGVKHLVVLVNKMDDPTVNWDQTRYNECKDKILPYLKKLGFNPAKDLTFMPCSGLS 386

Human   198 GDNMLE--PSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIG 260
            |..:.:  |....||::            |...:..:|.:....|.:|.|..:|:.|.||  .:|
  Fly   387 GYGLKDQIPETLCPWYR------------GPAFIPFIDELPSLNRKSDGPFIMPIVDKYK--DMG 437

Human   261 TVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNV 325
            ||.:|:||:|..:.|..:...|......|..:......::...||:||...:|.:..:||..|.|
  Fly   438 TVVMGKVESGTARKGQNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEEDVSPGFV 502

Human   326 AGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEK-----IDRRSGK 385
            ..|:.| |......|.|||:||.|...|.|||:.|:     ||.|...|:..|     :|::||.
  Fly   503 LCDAAN-PIKTGKIFDAQVVILEHKSIICAGYSAVM-----HIHCAAEEVTVKALICLVDKKSGD 561

Human   386 KLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVG-VIKAVD 442
            |.:..|:|:|....||:.:.....:|:|.|..:|.:|||.:||..:|:|:| |:|.|:
  Fly   562 KSKTRPRFVKQDQVAIMRIECSGMICLEQFKLFPQMGRFTLRDENKTIAIGKVLKVVE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EEF1A1	NP_001393.1	PTZ00141	1..460	CDD:185474	169/448 (38%)
		G1. /evidence=ECO:0000250	14..21		5/6 (83%)
		G2. /evidence=ECO:0000250	70..74		2/3 (67%)
		G3. /evidence=ECO:0000250	91..94		2/2 (100%)
		G4. /evidence=ECO:0000250	153..156		2/2 (100%)
		G5. /evidence=ECO:0000250	194..196		1/1 (100%)
eRF3	NP_001260415.1	PAM2	12..28	CDD:284542
		TEF1	191..619	CDD:227581	168/446 (38%)
		EF1_alpha	197..416	CDD:206670	98/230 (43%)
		eRF3_II	424..505	CDD:293906	24/82 (29%)
		eRF3_C_III	511..617	CDD:294003	39/110 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1150082at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X149
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920