Protein Alignment Prpf4b and Cdk12

DIOPT Version :10

• Sequence 1: NP_038858.2
• Gene: Prpf4b / 19134
• MGIID: 109584
• Length: 1007
• Species: Mus musculus
• Sequence 2: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Alignment Length: 1151
• Identity: 273/1151 - (23%)
• Similarity: 431/1151 - (37%)
• Gaps: 291/1151 - (25%)

Mouse     3 ATEPPSLREQAEMDDADNSEK------SVNEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHS 61
            ||.|   ||  |...|.|:.|      .:...:..:..|:.:.:..|.|:|      |.||.||
  Fly    93 ATNP---RE--EPSQASNTSKDELWGREIYMSSDSIDTDELEAEMKRQKRK------KQKKEKH- 145

Mouse    62 SEEDRDKKHKHKHKHKKHKRKEVIEASDKEGLSPAKRTKLDDLALLEDLEKQRALIKAELDNELM 126
                   |||.|.|.||.|:|.....|..:.:|.      :|:..|.|.........::.:...:
  Fly   146 -------KHKSKKKSKKRKKKRAKSYSSIDSMSD------NDINALLDRRYTPPTAPSKSNERTV 197

Mouse   127 EGKVQSGMGLILQGYESGS-EEEGEIHEKARNGN---RSS--TRSSSTRGKLEIT-DNKNSAKKR 184
            .....|.....|:  ||.| .....:.....|.|   .||  |.:|:....|::| .||.|...|
  Fly   198 SAAPSSFTPHNLK--ESSSPATPPPVRRPNTNSNYYGESSLETANSALGSNLQVTVTNKQSISNR 260

Mouse   185 SKS------------------RSKERTRHRSDKRKSKGAGEMLRE-KANRSKSKERRKSKSPSKR 230
            .:|                  |:...:.:.|......|:|.::|: :::|..:...::..|...|
  Fly   261 LRSPPPSSRSSGNGPRFGNSPRTPPPSHYSSSGGGGVGSGSVVRDSRSSRYVNSPHKEDVSAHHR 325

Mouse   231 S--------------KSQDQARKSK--SPPLRRRSQEKVGKARSPAEEKMKSEEKGKIKDRKKSP 279
            |              .|....||.|  ||.|.|.:.:       |:....|   :.|..|.::..
  Fly   326 SSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQ-------PSTPPHK---RRKFSDGREVG 380

Mouse   280 IVN-ERSRDRSKKSKSPVDLRDKSKDRRSRSKERKSKRSEIDKEKKPIKSPSKDASSGKENRSPS 343
            :.| |.||..|.|.:.      .|:||.|    |:|.||...:..:..:|||...|||    |.:
  Fly   381 LGNFEHSRHHSGKYER------YSRDRYS----RRSSRSPSVQHSRSRQSPSGGLSSG----SNA 431

Mouse   344 RRPGRSPKRRSLSPKLRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRR 408
            .|.|.|.|.:                    ..:..|.:||.|....:||........|..
  Fly   432 FRHGGSHKHK--------------------YGTTVSSTPSHTTRTSKRASGTGTSGDRYS----- 471

Mouse   409 LSSPRTRPRDDILGRCERSKDASPI---------NRWSP-TRRRSRSPIRRRSRSPLRRSRSPRR 463
             .||||.      .|...|...||:         :|.|| .|:|:|...||||.|. ..|.|...
  Fly   472 -RSPRTS------SRYMESSPPSPVGASGSHHYHHRRSPRMRQRTRGDSRRRSPSS-ASSESSAS 528

Mouse   464 RSRSPRRRDRSRRSRSRLRRRSRS-------RGGHRRRSRSK---VKEDKFKGSLSEG-MKVEQE 517
            |||||..||...:....:::.|.:       :..|:|:...|   .::::...|.|.| :.:...
  Fly   529 RSRSPTSRDLKHKREEYIKKISETSLFAELVKDRHKRQKALKEIIERQEENSNSNSNGALTINDN 593

Mouse   518 SSSDD-------------------------------------NLEDFDVEEEDEEALIEQ----- 540
            |||.|                                     :|.:..:..:..::::..
  Fly   594 SSSVDGNTPNAADGRSAPGSGTPAAASTTSNGLQALGSKPDLDLNNIPMPNKQNDSVVSNPASNA 658

Mouse   541 ------RRIQRQAIVQKYKYLAEDSNI---SVPSEPSSPQSS----TRSRSPSPDDILERVAADV 592
                  .::::..:|..:.  |..:||   |:.|.|..|..:    ..:|||||        ...
  Fly   659 DVPDSVAQLKQPLLVPPFS--ASKNNIKPKSLTSLPLPPGMNVLDLAGARSPSP--------GQK 713

Mouse   593 KEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKILA--PDMFTESDDMFAAYFDSARLRAAGIG 655
            ||.:.:||.:..::.|:..||.......||.:   |:  .|:....:|..|....:......|.|
  Fly   714 KESDEKNVTSSGSANKSVLNLPMPPVIPGSEE---LSGDDDVIDSPEDFDAPAVGTVHGHGGGPG 775

Mouse   656 KDFKENP---NLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVK 717
            .. ::.|   |.||:..:...:     ||.....:.:....|:|.:..|.:|||: ..|..||:|
  Fly   776 TT-RQRPVILNRRDSRNNVRDW-----GERCVDVFEMIAQIGEGTYGQVYKARDH-HTNDMVALK 833

Mouse   718 IIR---NNELMQKTGLKELEFLKKLND----------ADPDDKFHCLRLFRHFYHKQHLCLVFEP 769
            .:|   ..|....|.::|::.|::||.          .|..|.....:....||      ||||.
  Fly   834 KVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFY------LVFEY 892

Mouse   770 LSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCD 834
            :..:|..:|:....|......|  |..:||...|....:.|.||.|||..|||:| ::..:||.|
  Fly   893 MDHDLMGLLESGMVDFNEENNA--SIMKQLLDGLNYCHKKNFLHRDIKCSNILMN-NRGKVKLAD 954

Mouse   835 FGSAS-HVADNDITPY---LVSRFYRAPEIIIGKS-YDYGIDMWSVGCTLYELYTGKILFPGKTN 894
            ||.|. :.||:...||   :::.:||.||:::|:. |...||:||.||.|.||:..:.||.....
  Fly   955 FGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAE 1019

Mouse   895 NHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADL 959
            ...|:....:.|. |...:...|.|       |...:....|.|.|
  Fly  1020 MAQLETISKICGS-PVPAVWPNVIK-------LPLFHTLKQKKTHR------------------- 1057

Mouse   960 IGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 1005
               :||.||.........||||::|.|||.|||:...||:..::::
  Fly  1058 ---RRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRK 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prpf4b	NP_038858.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..102		29/104 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	141..535		109/494 (22%)
		PTZ00449	<171..>393	CDD:185628	58/258 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	560..583		11/29 (38%)
		STKc_PRP4	686..1003	CDD:271037	96/334 (29%)
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	98/346 (28%)