DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prpf4b and CG7028

DIOPT Version :9

Sequence 1:	NP_038858.2	Gene:	Prpf4b / 19134	MGIID:	109584	Length:	1007	Species:	Mus musculus
Sequence 2:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	1031	Identity:	440/1031 - (42%)
Similarity:	577/1031 - (55%)	Gaps:	180/1031 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse    33 SEDQSQNKHSRHKKKKHKHRSKHKKHKHSS----EEDRDKKHKHKHKHKKHKRKEVIEASDKEGL 93
            |.|.|.|..:..::.|||...||||||.||    |:||   |.||.:.|..||......|..|..
  Fly     6 SYDSSNNSETEERRAKHKKAKKHKKHKKSSTGKTEKDR---HVHKKQKKAKKRPHRTSESTNESD 67

Mouse    94 SPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKA-RN 157
            :| :..||                           |:....||        |.:..||.:|| ||
  Fly    68 AP-ENAKL---------------------------KLSQNCGL--------SSKFTEIMQKASRN 96

Mouse   158 GNRSSTRSSSTRGK-LEITDNKNSAKKRSKSRSKERTRHRSDKRKSKGAGEMLREKANRSKSKER 221
            |      :....|| |..||..:..::.:|:...:..             .:|...::.|:|...
  Fly    97 G------ADFRVGKPLLPTDPSSLVEEITKTIQNKML-------------PVLEVASSSSESDVP 142

Mouse   222 RKSKSPSKRSKSQDQARKSKSPPLRRRSQEKVGKARSPAEEKMKSEEKGKIKDRKKSP--IVNER 284
            ..:.||...|..:|:....:....:...|.::|...|..|    :|:||.:.....|.  :|:.:
  Fly   143 ADAASPIILSIIEDELNLEELMRQKALLQARLGAYMSDPE----AEDKGDLLPHTHSQQLVVHTK 203

Mouse   285 S---------RDRSKKSKSPVDLRDKSKDRRSRSKERKSKRSEI---DKEKKPIKSPSKDASSGK 337
            |         :.:..||.:|:...........:|....|..|::   |           |:|.|:
  Fly   204 SVLKAVTSVPQPQPSKSAAPLATATSKHANIKKSTTHNSNESDVILLD-----------DSSGGQ 257

Mouse   338 ENRSPSRRPGRSPKRRSLSP---KLRDKSRRSRSPLLNDRRSK-QSKSPSRTLSPGR------RA 392
              |:||..|.:  :||..||   ..|.:.||       ||||: :.:||.|..:..:      |:
  Fly   258 --RTPSPTPEK--RRRHASPLPAAPRSRCRR-------DRRSRDRDRSPPRRRASDQQTQVRPRS 311

Mouse   393 KSRSLERKRREPERRRLSSPRTRPRDDILGRCERSKDASPINRWSPTRRRSRSPIRRRSRSPLRR 457
            ::|::|..|:|..|.:....|...||    |..|..|..|    .||..|   |.|.|.|. :|.
  Fly   312 RNRNMEDLRQEINRDKQRERRDHSRD----RDRRGLDRPP----PPTDMR---PGRARERD-VRP 364

Mouse   458 SRSPRRRSRSPRRRDRSRRSRSRLRRRSRSRGGHRRRSRSKV---KEDKFKGSLSEGM-KVEQES 518
            ||..|..|||   :..|.|.|.|.|::.|.|||.|..:||..   ..|::|||||||. |:::||
  Fly   365 SRMQRSHSRS---KFESDRRRERERQKDRDRGGGRVGARSGTDNGDRDRYKGSLSEGQNKLDKES 426

Mouse   519 SSDDNLEDFDV-EEEDEEALIEQRRIQRQAIVQK----YKYLAEDSNISVPSEPSSPQSSTRSR- 577
            |.::...:.|: ||:|||.:||.||.:|:.:::|    .:..|..:::|..|..:|..||.|.|
  Fly   427 SDEEVNVNIDILEEDDEERIIELRRKKREELLKKLGTGQESPAPHNSVSYESRSTSQGSSQRERP 491

Mouse   578 -------SPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKILAP----- 630
                   .|.|:.::..:..|     ||::|                  |.:|||...|.
  Fly   492 LRTPSPTMPCPNPLISEIPKD-----REDMD------------------NSTSQKTCSAKEKRNE 533

Mouse   631 -DMFTESDDMFAAYFDSARLRAAGI---GKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYG 691
             |||.:.|  ..:.||.:|..:...   .|...|||.|.|||.||||||||.||||||.||.|.|
  Fly   534 WDMFADQD--VDSNFDVSRKISPNTIVQNKHQHENPALTDNWDDAEGYYRVRIGEVLDNRYLVNG 596

Mouse   692 YTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRH 756
            ||||||||||||.||.||....||:|||||||:|.||||:|||.|||||||||:|:||||||:||
  Fly   597 YTGQGVFSNVVRGRDQARGQANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDRFHCLRLYRH 661

Mouse   757 FYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNI 821
            |:||||||:|||||:||||||||||||:|||||||||||:|||||||||||:..|||||||||||
  Fly   662 FFHKQHLCMVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNI 726

Mouse   822 LVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGK 886
            ||||:..|||||||||||.::||:|||||||||||:||||:|..||||||.||.|||:|||||||
  Fly   727 LVNENNLILKLCDFGSASAISDNEITPYLVSRFYRSPEIILGIPYDYGIDTWSAGCTIYELYTGK 791

Mouse   887 ILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINP 951
            |||.||:||.|||..||:|||:||::||||.|::|||||:.||:|.|:||:|||||:.||..:.|
  Fly   792 ILFSGKSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQSCNFLYHEIDKLTEREKIVVMPVVKP 856

Mouse   952 TKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI 1007
            ::.|..:||..|.||:||.:||.||||||:.:..||||||||:||||.|.|||||:
  Fly   857 SRSLQQELIADQNLPDDQHRKVTQLKDLLENMFALDPAKRISLNQALVHPFIQEKM 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prpf4b	NP_038858.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102		28/72 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..535		114/424 (27%)
		PTZ00449	<171..>393	CDD:185628	51/246 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..583		9/30 (30%)
		STKc_PRP4	686..1003	CDD:271037	233/316 (74%)
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	233/316 (74%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	227/308 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845441
Domainoid	1	1.000	486	1.000	Domainoid score	I389
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	651	1.000	Inparanoid score	I783
Isobase	1	0.950	-	0	Normalized mean entropy	S2103
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003592
OrthoInspector	1	1.000	-	-		oto93387
orthoMCL	1	0.900	-	-		OOG6_102293
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R996
SonicParanoid	1	1.000	-	-		X2065
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.770