DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prph2 and Tsp86D

DIOPT Version :9

Sequence 1:	NP_032964.1	Gene:	Prph2 / 19133	MGIID:	102791	Length:	346	Species:	Mus musculus
Sequence 2:	NP_001262468.1	Gene:	Tsp86D / 41310	FlyBaseID:	FBgn0037848	Length:	316	Species:	Drosophila melanogaster

Alignment Length:	295	Identity:	76/295 - (25%)
Similarity:	125/295 - (42%)	Gaps:	72/295 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    20 LWLMNWLSVLAGIVLFSLGLFLKIE--------LRKRS--EVMNNSESHFVPNSLIGVGVLSCVF 74
            ::|:|:|..|.|.:|.::|::..::        ||..:  :|:.|     :...:|..||:  ||
  Fly    35 IFLLNFLFWLFGGLLLAIGVYAFMDKLMDGNGWLRLDTIYDVIFN-----ISLVMIIAGVI--VF 92

Mouse    75 N-SLAGKICYDALDPAKYAKWKPWLKPYLAVC-IFFNVILFLVALCCFLLRGSLESTLAYGLKNG 137
            . |.||  |..||      :...||....::| :.|.::...:|:.||:....:.|.|.|...:.
  Fly    93 TVSFAG--CLGAL------RENTWLLKLYSMCLLLFFILEMSLAIICFVFPQYMNSFLEYQFTDK 149

Mouse   138 MKY-YRDTDTPGRCFMKKTIDMLQIEFKCCG--NNGFRDWFEIQWISNRYLDFSSKEVKDRIKSN 199
            :.: |||...     ::..||..|.||.|||  |.|::||.:     |.|.:.||..| :|.
  Fly   150 IIHSYRDDSD-----LQNFIDFAQQEFNCCGLSNAGYQDWSK-----NEYFNCSSPSV-ERC--- 200

Mouse   200 VDGRYLVDGVPFSCCNPSSPRPCIQYQLTNNSAHYSYDHQT---EELNLWLRGCRAAL-----LN 256
                    |||:|||..::.   |...|.|....|....::   ....:|..||...:     .|
  Fly   201 --------GVPYSCCINATD---ISSGLVNIMCGYGVQVRSVAAASKRIWTSGCIEIVRVWVERN 254

Mouse   257 YYSSLMNSMGVVTLLVWLFEVSITAGLRYLHTALE 291
            .|.....::|:.  |:.||.:       ||...||
  Fly   255 LYVIAGVALGIA--LLQLFVI-------YLAKTLE 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prph2	NP_032964.1	Tetraspannin	20..277	CDD:278750	72/279 (26%)
		TDT	58..>123	CDD:296283	18/66 (27%)
		peripherin_like_LEL	120..262	CDD:239415	40/152 (26%)
		Interaction with MREG. /evidence=ECO:0000269\|PubMed:17260955	341..346
Tsp86D	NP_001262468.1	Tetraspannin	51..283	CDD:278750	70/279 (25%)
Tsp86D	NP_001262468.1	penumbra_like_LEL	132..255	CDD:239411	38/147 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810