Protein Alignment PHC1 and phc1

DIOPT Version :10

• Sequence 1: XP_011518905.1
• Gene: PHC1 / 1911
• HGNCID: 3182
• Length: 1021
• Species: Homo sapiens
• Sequence 2: NP_991270.2
• Gene: phc1 / 403008
• ZFINID: ZDB-GENE-081022-39
• Length: 897
• Species: Danio rerio
• Alignment Length: 1157
• Identity: 400/1157 - (34%)
• Similarity: 510/1157 - (44%)
• Gaps: 404/1157 - (34%)

Human     4 ESEQNSNSTNGSSSSGGSSR-PQIAQMSLYERQAVQALQALQRQPNAAQYFHQFMLQQQLSNA-- 65
            |.:.||:|||.|::|||:|| ||||||||||||||||||||||||||||||.|.|||||:::|
Zfish     5 EDQTNSSSTNSSAASGGNSRPPQIAQMSLYERQAVQALQALQRQPNAAQYFQQLMLQQQINSATC 69

Human    66 QLHSLAAVQQVRGQQPAGPRGRGQALQATIAASRQASSPNTSTTQQQTTTTQASINLATTSAAQL 130
            |||:|||||                 |||:|||||:||||.|.: |.|::.|.::||:||||...
Zfish    70 QLHNLAAVQ-----------------QATLAASRQSSSPNNSAS-QPTSSAQCTVNLSTTSAGGT 116

Human   131 ISRSQSV---SSPSATTLTQSVLLGNTTSPPLNQSQAQMYLRPQLGNLLQVNRTLGRNVPLASQL 192
            ::..:.:   :|.::|.|:||||||..:.     .|.|||||        |||:|  ..||..||
Zfish   117 MTNPRPIGPATSAASTALSQSVLLGGNSG-----GQGQMYLR--------VNRSL--RAPLTPQL 166

Human   193 ILMPNG----AVAAVQQEVPSAQ------------SPGVHADADQVQNLAVR------------- 228
            |.||.|    .||.|.|..|..|            |....:|.|||||||:|
Zfish   167 IFMPGGTATATVATVAQTQPQQQPQQQQQQEATPTSSSSQSDNDQVQNLAMRCVSTPRAATVKTE 231

Human   229 -------------NQQASAQGPQMQGSTQKAIPPGASPV--------SSLSQASSQALAVAQASS 272
                         |||  .|.||..|.:.:.:.|...|:        |:.:..|..||.|.
Zfish   232 FADRKETTGTFPLNQQ--TQTPQQFGQSTQQVQPQTQPLANAKLQSFSNTANPSVPALNVK---- 290

Human   273 GATNQSLNLSQAGGGSGNSIPGSMGPGGGGQAHGGLGQLPSSGMGGGSCPRKGTGVVQPLPAAQT 337
             ..|||....|..|.|.|  |.|..|            .||                  ||.:|
Zfish   291 -PNNQSAVAPQQAGASSN--PPSSSP------------TPS------------------LPLSQ- 321

Human   338 VTVSQGSQTEAESAAAKKAEADGSGQQNVGMNLTRTATPAPSQTLISSATYTQIQPHSLIQQQQQ 402
            :.:||.                       |::.|| ..||      |:||.|    |.|:
Zfish   322 LLLSQS-----------------------GLHQTR-GVPA------STATVT----HILV----- 347

Human   403 IHLQQKQVVIQQQIAIHHQQQFQHRQSQLLHTATHLQLAQQQQQQQQQQQQQQQPQATTLTAPQP 467
                                                                             
Zfish   348 ----------------------------------------------------------------- 347

Human   468 PQVPPTQQVPPS-----------QSQQQAQTLVVQPMLQSSP-------------LSLPPDAAPK 508
                ||..||.|           :|...||||||||:.|:..             :.:.|..|..
Zfish   348 ----PTSNVPTSTQGYPLGTVATKSNMTAQTLVVQPLQQTGANLSTEKLAHGTGHVPIQPKTAQG 408

Human   509 PPIPIQSK----PPVAPIKPPQLGAAKMSAAQQPPPHIPVQVVGTRQPGTAQAQALGLAQLAAAV 569
            ..:|:|..    ||:.| .||..|.|   .|...|||:|||:||.||.....:|||.|||.....
Zfish   409 HRVPVQMSPRHPPPILP-APPNNGQA---TAGLHPPHVPVQLVGARQSTLGNSQALALAQARTCC 469

Human   570 PTSRGMPGTVQSGQAHLASSPPSSQAPGALQECPPTLAPGMTLAPVQGTAHVVKGGATTSSPVVA 634
                    :.|.|.|.:..:.|.:..  .:.....|...||.|...| :|..:....|..|.|:.
Zfish   470 --------SQQDGTAAVGVNNPGNVV--TMVTAMDTSGAGMCLKTAQ-SALPISQMQTNQSAVLT 523

Human   635 Q-VPA--------------AFYMQSVHLPGKPQTLAVKRKADSEEERDDVSTLGSMLPAKASPVA 684
            | .||              :.::||.....||....:|||::|:... ::|.         .|::
Zfish   524 QGNPASVTHSMDGQNNSGDSLFVQSAQAQIKPAIGPIKRKSESDLTH-EISN---------EPIS 578

Human   685 ESPKVMDEKSSLGEKAESVANVNANTPSSELVALTPAPS---VP------PPTLAMV-------S 733
            .||.:.|                 :.|     .|:||||   ||      ||||::.       .
Zfish   579 GSPSMQD-----------------SAP-----PLSPAPSLDTVPEIAFSSPPTLSLSLPVPLPRG 621

Human   734 RQMGDSKP-PQAIVKPQILTHIIEGFVIQEGAEPFPVGCSQLLKESEKPLQTGLPTGLTENQSGG 797
            ...||..| |||:||||:|||:|||||||||||||||                  ||..:..||.
Zfish   622 AGQGDRAPVPQAVVKPQVLTHLIEGFVIQEGAEPFPV------------------TGPLKELSGA 668

Human   798 PLGVDSPSAELDKKANLLKCEYCGKYAPAEQFRGSKRFCSMTCAKRYNVSCSHQFRLKRKKMKEF 862
            ...:..|.   |.:::.||||||..:|||.|||.|||||:::|:||||||..:..|..|......
Zfish   669 VPPILHPE---DIRSDKLKCEYCLNFAPASQFRRSKRFCTISCSKRYNVSFRNHLRASRGLEGAE 730

Human   863 QEANYARV-----RRRGPRRSSSDIARAKIQG-----KCHRGQEDSSRGSDNSSYDE-------A 910
            :.|....|     |||.||||||:||.|||.|     ||   :.:|||..|.||.:.       :
Zfish   731 RPAGGPVVQDVIARRRAPRRSSSEIACAKITGRHLPVKC---RSESSRSDDISSCEGEEEEDFLS 792

Human   911 LSPTS----PGPLSVRAGHGERDLGNPNTAP---PTPELHGINPVFLSSNPSRWSVEEVYEFIAS 968
            |||:|    |.|.     |....|  .:|||   |..|.|     |||.||:.|||:||.:||:|
Zfish   793 LSPSSTFSCPRPT-----HCGPQL--DDTAPGGLPVDENH-----FLSGNPADWSVQEVCQFISS 845

Human   969 LQGCQEIAEEFRSQEIDGQALLLLKEEHLMSAMNIKLGPALKICAKINVLKE 1020
            ||||:::|.:|.|||||||||:|||||||||.|||||||||||||.||.|::
Zfish   846 LQGCEDLASQFLSQEIDGQALMLLKEEHLMSTMNIKLGPALKICASINSLRD 897

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHC1	XP_011518905.1	PHA03247	<491..687	CDD:223021	57/227 (25%)
		PHC2_SAM_assoc	845..952	CDD:465202	46/130 (35%)
		SAM_Ph1,2,3	952..1020	CDD:188976	50/67 (75%)
phc1	NP_991270.2	None