DRSC/TRiP Functional Genomics Resources

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Protein Alignment Prkg2 and Pka-C1

DIOPT Version :9

Sequence 1:NP_032952.3 Gene:Prkg2 / 19092 MGIID:108173 Length:762 Species:Mus musculus
Sequence 2:NP_476977.1 Gene:Pka-C1 / 34284 FlyBaseID:FBgn0000273 Length:353 Species:Drosophila melanogaster


Alignment Length:363 Identity:148/363 - (40%)
Similarity:210/363 - (57%) Gaps:34/363 - (9%)


- Green bases have known domain annotations that are detailed below.


Mouse   386 TFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSM-SSWKLSKALSLEMIQLKEKVARFSSTSP 449
            |.|:.|...:.::::||             .||... ..|:.:.                ::|:.
  Fly     7 TSNKKVDAAETVKEFLE-------------QAKEEFEDKWRRNP----------------TNTAA 42

Mouse   450 FQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIV 514
            ..:.|.|.|||.|.||||.:|:.|.....:|||.:.|:.:|..||.||..:|||||:.:..||:|
  Fly    43 LDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLV 107

Mouse   515 KLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKP 579
            .|...||||..:||:||...|||::|.||..|.|.||.|:|..|.:..||:|||.|.:|||||||
  Fly   108 SLRYHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKP 172

Mouse   580 ENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELL 644
            |||::|:.||||:.||||||::..  :|||.||||||:|||:||:||::.:||:|:||:||||:.
  Fly   173 ENLLIDSQGYLKVTDFGFAKRVKG--RTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMA 235

Mouse   645 TGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHR 709
            .|.|||.....:..|..|:.|  |:.||.......:||:|.|.:.:.|:|.||||.|:||||..:
  Fly   236 AGYPPFFADQPIQIYEKIVSG--KVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKNQK 298

Mouse   710 WLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPE 747
            |....:|..:..:.:.:|......||.|.|.||.|..|
  Fly   299 WFASTDWIAIFQKKIEAPFIPRCKGPGDTSNFDDYEEE 336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Prkg2NP_032952.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..138
Crp 162..>285 CDD:223736
cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000250|UniProtKB:Q13237 168..283
CAP_ED 168..273 CDD:237999
cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000250|UniProtKB:Q13237 286..416 5/29 (17%)
CAP_ED 286..401 CDD:237999 3/14 (21%)
PTZ00263 417..752 CDD:140289 143/332 (43%)
STKc_cGK 459..718 CDD:270724 127/258 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 740..762 4/8 (50%)
Pka-C1NP_476977.1 STKc_PKA 44..333 CDD:271111 137/292 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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