DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prkg2 and Pkg21D

DIOPT Version :9

Sequence 1:	NP_032952.3	Gene:	Prkg2 / 19092	MGIID:	108173	Length:	762	Species:	Mus musculus
Sequence 2:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster

Alignment Length:	788	Identity:	349/788 - (44%)
Similarity:	489/788 - (62%)	Gaps:	81/788 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse    20 NLSN--EALR-------SKVLELERELRRKDAELQEREYHLKELREQLAKQTV-AIAELTEELQS 74
            ||:.  :|||       |::::|.||:.:..:.||:...:|...|.:.||:.: ::.|...|.:|
  Fly    17 NLTKDVQALREMVRSRESELVKLHREIHKLKSVLQQTTNNLNVTRNEKAKKKLYSLPEQCGEQES 81

Mouse    75 K-----------------------CIQLNKLQDVIHVQGGSPL------QASPDKVPLDVHRKTS 110
            :                       .:.|..|..:......||.      :..|..:|..:
  Fly    82 RNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTSADEVRPKAMPAAI----- 141

Mouse   111 GLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQ 175
                      .|.|||||...::..    ..:|....:..||.|:|:.|.||:..|.|||.:|..
  Fly   142 ----------KKQGVSAESCVQSMQ----QSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDAS 192

Mouse   176 QIKDMVECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 240
            |::::|:.||.::...|.:||::||.|.|::|.|.|...|.|..|:|..:.....||||||||||
  Fly   193 QVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILYNC 257

Mouse   241 TRTASVKAITN-VKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEV 304
            |||||::.::. .:.|.|||.|||.||..|...|.|...||||||.||.||.|:.|.||.|.||:
  Fly   258 TRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLEL 322

Mouse   305 EYYDKGDYIIREGEEGSTFFILAKGKVKVTQS-TEGHDQPQLIKTLQKGEYFGEKALISDDVRSA 368
            |:|..|.||||:|..|.:||::::|.|:|||. |....:...::||.:|:||||:|||::|.|:|
  Fly   323 EFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTA 387

Mouse   369 NIIAEENDVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLE 433
            ||||....|.||.:||::|.:.:|...||::...|        ||.|         ||:...:.|
  Fly   388 NIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYG--------DESR---------KLAMKQAQE 435

Mouse   434 MI--QLKEKVARFSSTSPFQNLEIIATLGVGGFGRVELVKVKNENVA--FAMKCIRKKHIVDTKQ 494
            ..  :.||::.:........:||:::|||:||||||||||..:::..  ||:||::|:|||||||
  Fly   436 SCRDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQ 500

Mouse   495 QEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVAC 559
            :||::||:.|:....||||.:|||||:|.||||||||||:|||:|::|||||||::..::|.:.|
  Fly   501 EEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGC 565

Mouse   560 VTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILN 624
            |.:||:|||..||||||||||||:||..||:|:|||||||:||:..|||||||||||||||:|||
  Fly   566 VLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILN 630

Mouse   625 KGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQ 689
            ||||.:||:|:||||::|||.|.||||..|.|.|||||||||:.:.||:.|:|....||:||||.
  Fly   631 KGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRD 695

Mouse   690 NPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKGVPPDE 754
            .|:||||....||.|||||:|..||:|:||.::.|..|..|.::.|.|..|||::|.:...||||
  Fly   696 VPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRFPCDLNEPPDE 760

Mouse   755 MSGWDKDF 762
            :||||.||
  Fly   761 LSGWDADF 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prkg2	NP_032952.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..138		6/19 (32%)
		Crp	162..>285	CDD:223736	56/123 (46%)
		cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000250\|UniProtKB:Q13237	168..283		52/115 (45%)
		CAP_ED	168..273	CDD:237999	47/105 (45%)
		cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000250\|UniProtKB:Q13237	286..416		57/130 (44%)
		CAP_ED	286..401	CDD:237999	54/115 (47%)
		PTZ00263	417..752	CDD:140289	187/338 (55%)
		STKc_cGK	459..718	CDD:270724	168/260 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	740..762		12/21 (57%)
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	95/202 (47%)
		CAP_ED	185..285	CDD:237999	45/99 (45%)
		CAP_ED	304..419	CDD:237999	54/114 (47%)
		Pkinase	457..717	CDD:278497	167/259 (64%)
		STKc_cGK	463..724	CDD:270724	168/260 (65%)
		S_TK_X	719..>760	CDD:214529	16/40 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	80	1.000	Domainoid score	I8629
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4556
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1264
OMA	1	1.010	-	-		QHG57714
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.670