Protein Alignment Prkg2 and Pkg21D

DIOPT Version :10

• Sequence 1: NP_032952.3
• Gene: Prkg2 / 19092
• MGIID: 108173
• Length: 762
• Species: Mus musculus
• Sequence 2: NP_477213.1
• Gene: Pkg21D / 33253
• FlyBaseID: FBgn0000442
• Length: 768
• Species: Drosophila melanogaster
• Alignment Length: 788
• Identity: 349/788 - (44%)
• Similarity: 489/788 - (62%)
• Gaps: 81/788 - (10%)

Mouse    20 NLSN--EALR-------SKVLELERELRRKDAELQEREYHLKELREQLAKQTV-AIAELTEELQS 74
            ||:.  :|||       |::::|.||:.:..:.||:...:|...|.:.||:.: ::.|...|.:|
  Fly    17 NLTKDVQALREMVRSRESELVKLHREIHKLKSVLQQTTNNLNVTRNEKAKKKLYSLPEQCGEQES 81

Mouse    75 K-----------------------CIQLNKLQDVIHVQGGSPL------QASPDKVPLDVHRKTS 110
            :                       .:.|..|..:......||.      :..|..:|..:
  Fly    82 RNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTSADEVRPKAMPAAI----- 141

Mouse   111 GLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQ 175
                      .|.|||||...::..    ..:|....:..||.|:|:.|.||:..|.|||.:|..
  Fly   142 ----------KKQGVSAESCVQSMQ----QSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDAS 192

Mouse   176 QIKDMVECMYGRNYQQGSYVIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNC 240
            |::::|:.||.::...|.:||::||.|.|::|.|.|...|.|..|:|..:.....||||||||||
  Fly   193 QVRELVDSMYSKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILYNC 257

Mouse   241 TRTASVKAITN-VKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEV 304
            |||||::.::. .:.|.|||.|||.||..|...|.|...||||||.||.||.|:.|.||.|.||:
  Fly   258 TRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLEL 322

Mouse   305 EYYDKGDYIIREGEEGSTFFILAKGKVKVTQS-TEGHDQPQLIKTLQKGEYFGEKALISDDVRSA 368
            |:|..|.||||:|..|.:||::::|.|:|||. |....:...::||.:|:||||:|||::|.|:|
  Fly   323 EFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTA 387

Mouse   369 NIIAEENDVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLE 433
            ||||....|.||.:||::|.:.:|...||::...|        ||.|         ||:...:.|
  Fly   388 NIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYG--------DESR---------KLAMKQAQE 435

Mouse   434 MI--QLKEKVARFSSTSPFQNLEIIATLGVGGFGRVELVKVKNENVA--FAMKCIRKKHIVDTKQ 494
            ..  :.||::.:........:||:::|||:||||||||||..:::..  ||:||::|:|||||||
  Fly   436 SCRDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQ 500

Mouse   495 QEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVAC 559
            :||::||:.|:....||||.:|||||:|.||||||||||:|||:|::|||||||::..::|.:.|
  Fly   501 EEHIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGC 565

Mouse   560 VTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILN 624
            |.:||:|||..||||||||||||:||..||:|:|||||||:||:..|||||||||||||||:|||
  Fly   566 VLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILN 630

Mouse   625 KGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQ 689
            ||||.:||:|:||||::|||.|.||||..|.|.|||||||||:.:.||:.|:|....||:||||.
  Fly   631 KGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRD 695

Mouse   690 NPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKGVPPDE 754
            .|:||||....||.|||||:|..||:|:||.::.|..|..|.::.|.|..|||::|.:...||||
  Fly   696 VPSERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRFPCDLNEPPDE 760

Mouse   755 MSGWDKDF 762
            :||||.||
  Fly   761 LSGWDADF 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prkg2	NP_032952.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..138		6/19 (32%)
		cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000250|UniProtKB:Q13237	168..283		52/115 (45%)
		CAP_ED	168..273	CDD:237999	47/105 (45%)
		cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000250|UniProtKB:Q13237	286..416		57/130 (44%)
		CAP_ED	286..401	CDD:237999	54/115 (47%)
		STKc_cGK	459..718	CDD:270724	168/260 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	740..762		12/21 (57%)
Pkg21D	NP_477213.1	CAP_ED	185..285	CDD:237999	45/99 (45%)
		CAP_ED	304..419	CDD:237999	54/114 (47%)
		STKc_cGK	463..724	CDD:270724	168/260 (65%)
		S_TK_X	719..>760	CDD:214529	16/40 (40%)