DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prkg1 and Pkg21D

DIOPT Version :9

Sequence 1:	NP_035290.1	Gene:	Prkg1 / 19091	MGIID:	108174	Length:	686	Species:	Mus musculus
Sequence 2:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster

Alignment Length:	765	Identity:	371/765 - (48%)
Similarity:	488/765 - (63%)	Gaps:	102/765 - (13%)

- Green bases have known domain annotations that are detailed below.

Mouse    19 RQRDALIDEL--------ELELDQKDELIQKLQNELDKYRSVIRPAT------------------ 57
            |:|:|::..|        |:...::.||: ||..|:.|.:||::..|
  Fly     9 REREAIVSNLTKDVQALREMVRSRESELV-KLHREIHKLKSVLQQTTNNLNVTRNEKAKKKLYSL 72

Mouse    58 ------QQAQKQS------------------------------ASTLQGEP--RT---------- 74
                  |:::.|:                              |||....|  ||
  Fly    73 PEQCGEQESRNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTSADEVRPKAM 137

Mouse    75 ----KRQAISAEPTAFDIQDLSHVTLPFYPKSPQSKDLIKEAILDNDFMKNLELSQIQEIVDCMY 135
                |:|.:|||.....:|....:.:|.|.|....|..||:||:||||:||::.||::|:||.||
  Fly   138 PAAIKKQGVSAESCVQSMQQSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDSMY 202

Mouse   136 PVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTATVKTLV 200
            .........:|:||:||:.:||...|:..|.::|..|..||.||.||||||||||||||:::.|.
  Fly   203 SKSIAAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVLDKMGAGKAFGELAILYNCTRTASIRVLS 267

Mouse   201 N-VKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPDEILSKLADVLEETHYENGEYII 264
            . .::|.:||:.||.|||.|||.:....:.||:|||...:|.:|:|:|:|||||...|..|.|||
  Fly   268 EAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAKIADVLELEFYAAGTYII 332

Mouse   265 RQGARGDTFFIISKGQVNVTREDSP-SEDPVFLRTLGKGDWFGEKALQGEDVRTANVIA-AEAVT 327
            |||..||:||:||:|.|.||::.:| |.:...||||.:||:|||:||..||.||||:|| :..|.
  Fly   333 RQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALINEDKRTANIIALSPGVE 397

Mouse   328 CLVIDRDSFKHLIGGLDDVSNKAYEDA---------------EAKAKYEAEAAFFANLKLSDFNI 377
            ||.:||||||.|||.|.::..|.|.|.               |.|.:.:.|   |.:|||:|..:
  Fly   398 CLTLDRDSFKRLIGDLCELKEKDYGDESRKLAMKQAQESCRDEPKEQLQQE---FPDLKLTDLEV 459

Mouse   378 IDTLGVGGFGRVELVQLKSEES-KTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYR 441
            :.|||:|||||||||:...::. ..||:|.|||||||||:|:|||.||:.||..:.|.||.||||
  Fly   460 VSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPFICRLYR 524

Mouse   442 TFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLI 506
            ||:|.||:|||:|||:|||:||:|||||||||:..:|...||::||.|||::||||||||||||:
  Fly   525 TFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLM 589

Mouse   507 LDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSP 571
            ||.|||.|:|||||||:||...|||||||||||||||||||||||.:.|||:||||::|||.|:|
  Fly   590 LDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTP 654

Mouse   572 PFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEG 636
            |||.||||:|||:||:|||||.|||.|::.|..|||:||||.||||||....|::||:|||||.|
  Fly   655 PFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFLG 719

Mouse   637 FNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF 686
            |:|:||....|.||.:..:|.|||...||.||.|.:| |||:.||||.||
  Fly   720 FDWDGLASQLLIPPFVRPIAHPTDVRYFDRFPCDLNE-PPDELSGWDADF 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prkg1	NP_035290.1	DD_cGKI-beta	4..55	CDD:213375	13/43 (30%)
		Crp	116..>218	CDD:223736	49/102 (48%)
		CAP_ED	118..227	CDD:237999	51/109 (47%)
		CAP_ED	237..341	CDD:237999	58/105 (55%)
		PTZ00263	368..676	CDD:140289	199/308 (65%)
		STKc_cGK	381..641	CDD:270724	179/260 (69%)
		S_TK_X	636..>679	CDD:214529	21/42 (50%)
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736	100/202 (50%)
		CAP_ED	185..285	CDD:237999	46/99 (46%)
		CAP_ED	304..419	CDD:237999	61/114 (54%)
		Pkinase	457..717	CDD:278497	175/259 (68%)
		STKc_cGK	463..724	CDD:270724	179/260 (69%)
		S_TK_X	719..>760	CDD:214529	20/41 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57714
OrthoDB	1	1.010	-	-		D123183at33208
OrthoFinder	1	1.000	-	-		FOG0001832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100630
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2508
SonicParanoid	1	1.000	-	-		X815
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760