DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Prkdc and nonC

DIOPT Version :9

Sequence 1:NP_035289.2 Gene:Prkdc / 19090 MGIID:104779 Length:4128 Species:Mus musculus
Sequence 2:NP_001284967.1 Gene:nonC / 31625 FlyBaseID:FBgn0263968 Length:3218 Species:Drosophila melanogaster


Alignment Length:2859 Identity:514/2859 - (17%)
Similarity:912/2859 - (31%) Gaps:1068/2859 - (37%)


- Green bases have known domain annotations that are detailed below.


Mouse  1520 GGLCDHLVSLLLNSAML---STQYLGSSQRNISFSHGEYFYSLFSEVINSELLKNLDIAVSRLME 1581
            ||...|.|:....:|:|   ....:|..|..:. :|.: .|....:.|| .:....|:.:|:::.
  Fly    75 GGGKSHDVAQAFANALLLRNMNHVVGKGQPVVQ-NHRK-AYQCKGDTIN-PMANGEDLRLSKIIR 136

Mouse  1582 S--SSDNPKMVSTVLNGMLDTSFRDRAVQKHQGLKLATAILQNWRKCDSWWAPDSA----PESKT 1640
            .  :.:|| .||..|...||.:.|             |.|...:..|...|..|:.    .:...
  Fly   137 RLINENNP-TVSLELCSKLDQAVR-------------TPINMGYMTCSFVWILDNMLTLYKQCPP 187

Mouse  1641 TVLSLLAKMLQIDSALSFDT----------NHSSFSE-----IFTTYASLLADTKLGLHLKGQAI 1690
            .||...:|.|.:...::..:          |:.|...     |....|:|..|||..||:....|
  Fly   188 PVLEECSKTLGLIGFINRKSYPIYEEFIVKNYKSSKRMQKYMIMALRATLSCDTKCELHMYADKI 252

Mouse  1691 ILLPFFTSLREGSLENLKHILEKLIVCN-FPMKSDEFPPDSLKYNNYVDCMKKFLDA-------- 1746
            :||             ||..||.....: |.:.|:.....:..|....:|  .|.|.        
  Fly   253 MLL-------------LKDFLENAESADIFIVVSNTLVQFAASYAETFEC--HFTDVVDIVIGWQ 302

Mouse  1747 LELSQ---------------SP-----------MLFQLMTDILCREQ---RHIMEEL------FQ 1776
            ||..|               :|           :|.|.:.||...|:   .:..|.:      |.
  Fly   303 LEAGQPTDLKTHCAQVLEQLTPFFSKQIDFSYGLLDQFVEDITTLEEGEPANTAERVGAFVGAFN 367

Mouse  1777 TTFKRIARQS--------PCVTQL---NLLESVYTMFRKADLPSNVTRQAFVDRSLLT------- 1823
            |..|.:||..        .|:.::   :|::.:.|:....:...|:.....:  .||.       
  Fly   368 TLLKCLARMQIFVGMPTCECIVKMAVDHLIKIMPTLHLNTEALVNINELICI--CLLNNFTGLDP 430

Mouse  1824 -LLWHCDLDTLKEFFS----------RIVVDAIDVLKSRFT-KLNEFTFDTQ--ITK-------- 1866
             ||....||.:|...|          .:::..:..|::|.| .|..|.|.:.  :||        
  Fly   431 ILLEQVLLDQVKRMISLTELQRQSVLYLLLCTVRRLRARLTPSLVHFIFQSNPYMTKVRLRSPGE 495

Mouse  1867 -------KMCYYKML---------AVMYSRLLKDDV--------------HSKEAKINQAFHGSR 1901
                   :.|...:|         |..|   |.||:              .:::|.:...||.|.
  Fly   496 TSYKLLLRTCQETLLIRNVPLLQQAYKY---LVDDIDACLEKLLITAPRSKARKASVLLVFHLSA 557

Mouse  1902 VAEGNELTKTLLKLCHDAFTENMVGESQLLEKRRLYHCAAYNCAISLISCVFNELKFYQGFLFNE 1966
            :|   .|.|.         |.:::|         :|.|......:.|.:|..:||||:..:    
  Fly   558 LA---ALAKQ---------TSSIIG---------MYACKPSILELLLTNCRAHELKFWSKY---- 597

Mouse  1967 KPEKNLFIFENLIDLKRCYTFPIEVEVPMERKKKYIEIRKEARDAANGASGSPHYMSSLSYLTDS 2031
             |.....||..|:                                       .|..::.::.|:|
  Fly   598 -PAAQQAIFGLLV---------------------------------------VHCQANHNFRTNS 622

Mouse  2032 SLSEEMSQFDFSTGVQSYSYSSQDRKPTTGHFQRREHQDSMTQDDIMELEMDELNQHECMAPMIA 2096
            ||            ::....|:::..||...|                                 
  Fly   623 SL------------LRDQELSAENTSPTANSF--------------------------------- 642

Mouse  2097 LIKHMQRNVIAPKGEEGSIPKDLPPWMKFLHDKLGNAS--VSLNIRLFLAKLVINTEEVFRPYAK 2159
                            .||       ::||...||.|.  ...|:|:.|                
  Fly   643 ----------------ASI-------LRFLDSVLGQAHQLAPQNLRVLL---------------- 668

Mouse  2160 HWLSPLLQLAVCENNREGIHYMMVE---------IVATILSWTGLATPTGVPKDEVLANRLLRFL 2215
            .|:..||:  .|   ||.|..:|.:         |.||......|.:...:              
  Fly   669 QWIQMLLR--EC---REKIDLLMEQENFRGICRNIAATASKLVPLESAACI-------------- 714

Mouse  2216 MKHVFHPKRAVFRHNLEIIKTLVECWKECLSIPYRLIFEKFSHKDPNSKDNSVGIQLLGIVIANN 2280
                    :.|..:.||.::...:     |.|.||                ...:|.|.::..|.
  Fly   715 --------QTVLDYGLERLEKYPK-----LLILYR----------------DTALQQLQMLSTNY 750

Mouse  2281 LPPYDPNCDITSAMYFEALVNNMSFVKYKEVYAAAAEVLGL---------------------ILQ 2324
            ..|                        |.::||.....|.|                     |.|
  Fly   751 HAP------------------------YFQIYAQLPLHLTLTGGESSMPGMASRRVSVWQQRISQ 791

Mouse  2325 YITERKHVIAELVCELVIKQLKQHQNTMEDKFIVCLNKI---AKGFPPLADRFLNALFFLLPKFH 2386
            |...|.:|..:.        ..:.|...:|..|.||.::   :....|..:|.:|.         
  Fly   792 YSAVRDNVFRDF--------FDRVQKPEQDSLIHCLRELFVRSCQVAPQDERQMNL--------- 839

Mouse  2387 GVMKTLCLEVVLCRAEEITGLYLQLKSKDFLQVMRHRDDERQKVCLDIVYKMVAKLKPIELR--E 2449
                :.|.:    |.:.:...:||      .:..|:..|:|.:..:....:.....:.|.:|  .
  Fly   840 ----SQCTK----RCQRLAIAWLQ------FEAARYCVDQRLRTTVGKPQETFLGFEAIIMRHAR 890

Mouse  2450 LLNPVVEFVSHPSPTCREQMYNILMWIHDNYRDQESQNDEDSQEIFKLAKDV-LIQGLIDENVGL 2513
            ||:           .|.:::            ::.:.:|...:|:..:..:: |:.|.:|   .|
  Fly   891 LLS-----------GCAKEI------------ERSALDDLSLEELLSMQSNLSLLLGFLD---AL 929

Mouse  2514 QLIIRNFWSHETRLPSNTLDRLLALNSLYS---PKIEVHFLSLATNFLLEMTRMSPDYLNPIFEH 2575
            :.:|.|                .|..|.::   |:.:|     |..|.|.         ||    
  Fly   930 EKLIYN----------------AAEGSAFALRPPEKQV-----AAFFRLN---------NP---- 960

Mouse  2576 PLSECEFQEYTIDPDW--RFR-STVLTPMFIETQASPSILHTQTQEGPLSDQRQKPGQVRATQQQ 2637
               .|:        .|  |.| ..|:..|.::   .|.::....|:..::.:.|.|         
  Fly   961 ---TCQ--------SWFNRIRIGVVIIAMHVQ---QPELVIRYAQQILVNSKTQDP--------- 1002

Mouse  2638 YDFTPTQASVERS-------------------------SFDWL-------TGSSIDLLADH-TVF 2669
               |.:||.|..:                         |:.||       .|.....||.: |:.
  Fly  1003 ---TYSQAIVYMAWSLVSCQEADSLRGLRLWARGKSCKSYKWLKYAADQAAGKRESALAGYRTIL 1064

Mouse  2670 SSETLSSSLLFSHKRTEKSQRMSC-KSVGP-----DFGTKKLGLPDDEVDNQVKSGTPSQADILR 2728
            :.:.|.|.|....::...||.|.| :.:|.     :...:::..|:|...|....  .|..::..
  Fly  1065 AEKELQSELEPHTRQFVVSQMMQCLQDLGQWSQLVELKQQQMTRPEDRELNPFLQ--RSNVEVNA 1127

Mouse  2729 LRRRFLKDREKLSLLYAKRGLMEQ----------------KLEKDIKSEFKMKQDAQ-VVLYRSY 2776
            |.|...|..|..|.:.|..|:.:|                ..|:...|...|:|..: :||::..
  Fly  1128 LERLLAKSEESCSSMDALGGVFQQLSLWPSNWDESVSSSGLSERASFSSIHMRQRTEDIVLHKLL 1192

Mouse  2777 RHGDLP-------DIQIQHSGLITPLQAVAQKDPIIAKQLFSSLFSGILKEMNKFKTTSEKNIIT 2834
            ....:|       |.|.:.|.|.......:.|:..:.:.:...:..|  :|::....:|.:    
  Fly  1193 EDRCVPDQAKNLLDTQWRDSLLNPSFDQRSCKELTLLRHIVQGVSGG--QELSLLPVSSGR---- 1251

Mouse  2835 QNLLQDFNRFLNTTFLFFPPFVSCI--QEISCQHPDFLTLDPASVRVGCL---ASLQQPGGIRLL 2894
               .|:.::|:::..|     :.|:  .::..||     ..|.|....||   |:.::.|.::|.
  Fly  1252 ---CQNRSKFISSAIL-----MRCLAWTQLLRQH-----CAPGSWETLCLDAAAAAREEGNLQLA 1303

Mouse  2895 EEALLRLMPKEPPTKRV-------RGKTCLPPDVLR-WMELAK-LYRSIGEYDVLRGIFSSELGT 2950
            |..|.:...:  |...:       :|.....|::|| :.||.| |:....:.....|..||.:  
  Fly  1304 ETLLTQFFGQ--PIGEIAALFSLEQGVQTDNPEMLRGYSELVKCLHLQQQQSQTHSGDLSSSI-- 1364

Mouse  2951 TQDTQNALLAEARSDYCQAAKLYDEALNKLEWVDGEPTEAEKEFWELASLDCYNNLSKWKELEYC 3015
                          |.|.|..|      .::..:.:|.         |..|...||:.|..:..|
  Fly  1365 --------------DVCAALCL------NIQKSNNQPA---------AGADLLLNLADWIAVRTC 1400

Mouse  3016 STVNIVSENSLDLSKMWSEPFYQETYLPYVIRSKLKLLLQGEGNQS--LLTFVDEAMNKELQKTV 3078
            :.:..                                      |||  |:..:|     :|.:..
  Fly  1401 NGLTT--------------------------------------NQSPVLIQLLD-----QLPECP 1422

Mouse  3079 LELQYSQELSLLYILQDDIDRATYYIKNGIQIFMQ---NYSSIDVLLYRSRLAKLQSVQTLAEIE 3140
            |....||.|:        |.:|...:...:...:|   ||:                       |
  Fly  1423 LTCDSSQPLA--------IPQAERMVARLVHSCLQQRPNYA-----------------------E 1456

Mouse  3141 EFLSFICKHGDLSSLGPLRRLLKTWTSRYPDVVTDPMHIWDDIITNRCFFLSK-----IEERLTA 3200
            ..:::                 ..|..|           |...:.:.|..|::     |.:.|..
  Fly  1457 ALIAY-----------------GNWCYR-----------WGKKVADSCCVLTQADATAISQALDI 1493

Mouse  3201 PSGDHSMSVDEDEESIDREVYEPKEDVRCMLQSCRFTMKMKMIESAWKQSNFSLSMKLLKEMHKE 3265
            |....|..:||..:::..|    :....| ::.|....:.:..|:|   .|....:..|.:...|
  Fly  1494 PQPLESEKLDELLQALSTE----QPPANC-VEVCPDAARARDDEAA---KNRLRRLTFLADKTPE 1550

Mouse  3266 S--KTREIWRVQWLHSYSQL-NHCRSHTQSPREQVLNMLKTITLLDESDISNYLNKNIQASCDQS 3327
            :  ...:|||....::|... :..||:.|      ....|:.:..::.:....:::..:...|.|
  Fly  1551 ALDAILQIWRRAIANTYDYYKDAARSYFQ------YLSFKSGSGPEKPEGEGVVSQRERLHVDDS 1609

Mouse  3328 ILLGTTCRIMADALSREPACLSDLEENKVNSILTLSGSNAENTETVITGLYQRAFHH---LSKAV 3389
            .|:.||.|::...:.........||:.       |..:.....:.:|..|:.|..||   :.|:|
  Fly  1610 NLVTTTLRLLRLIVKHASGLQEVLEQG-------LHTTPIAPWKVIIPQLFSRLNHHEPYVRKSV 1667

Mouse  3390 -----QSAEEETQLSCWGHEAAAERAHAYMTLVGFCDQQLRKVEESASQKTSAEMEAYPALVVEK 3449
                 :.|:...||..:.....|.|           :||......:.::.|:.:...|..|:.|.
  Fly  1668 CDLLCRLAKSRPQLVIFPAVVGANR-----------EQQDATAPPATARPTTEDACCYGYLLGEL 1721

Mouse  3450 MLRALKLNSSEARLKFPRLLQIIEQYSEETLNIMTKEISSIPC--WQFIGWISHMMALLDKEEAI 3512
            ..:|            |..:|.::        :|.||:..: |  |... ||             
  Fly  1722 SKQA------------PEAVQHVK--------LMVKELRRV-CLLWDEY-WI------------- 1751

Mouse  3513 AVQHTVEEIADNYPQAIIYPFIISSESYSFK-NTSSGHNNKAFVERIKSKLDHGEVIHSFINALD 3576
               |::..|.:.|...      :|:.:..|: :...|.||:..|.|                   
  Fly  1752 ---HSLAHIYNTYVSR------VSALATDFRPDDHEGKNNRFNVWR------------------- 1788

Mouse  3577 QLSNPDLLFKDWVSDTKDELGKNPVNKKNIEKLYERMYAALGDLRAPGLGPFR--------RRFI 3633
                |.||     :|.:..:.   |..:..|..|||.:....|      .|.|        ||:.
  Fly  1789 ----PQLL-----ADLEALVA---VTSRPPETTYERSFRKRFD------APIRLTVDALRHRRYP 1835

Mouse  3634 QAFGK----------EFVKSFGNGGSKLLTMKVDD----FCKITGSLLVRMKKDSKLPGNLKEYS 3684
            :|:.|          ..::..|:      |:|:..    .|.| |.:.:.|      || |..:.
  Fly  1836 EAWDKLKQLYHILQSNMIRGSGS------TLKMQSISPVLCGI-GRMRISM------PG-LDAHG 1886

Mouse  3685 PWMSEFKAQFLKNELEIPGQYDGKSKPLPEYHVRISGFDERVKVMLSLRKPKRIVIRGHDEKEYP 3749
            |                    ||.       .|.|...:..|.|:.:..|||::...|.:.:.|.
  Fly  1887 P--------------------DGD-------QVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYT 1924

Mouse  3750 FLVKGGEDLRQDQRIEQIFEVMNAILS--QDA---ACSQRNMQLRTYRVVPMTSRLGLIEWIENT 3809
            ||.||.|||..|:||.|...:.|||::  .||   .|    .:...|.|:|:..:.|||.|::..
  Fly  1925 FLFKGMEDLHLDERIMQFLSISNAIMACRSDAPGNGC----YRAHHYSVIPLGPQSGLISWVDGV 1985

Mouse  3810 MTLKDLLLSNMSQEEKVANNSDPKAPIRDYKDWLMK---VSGKSDAGAYV--------LMYSRAN 3863
            ..:..|                       ||.|..:   |:|.:.|||..        |.|::.:
  Fly  1986 TPVFAL-----------------------YKKWQQRRSQVAGNAGAGAVANVPRRFTDLFYNKLS 2027

Mouse  3864 ----RTETVVAFRRRE--------------SQVPPDLLKR-AFVKMSTSPEAFLALRSHFASSHA 3909
                :....|:..||:              .:.|.|||.| .:.:...:.|...::| .|....:
  Fly  2028 PLLAKHNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVR-RFVRCMS 2091

Mouse  3910 LLCISHWLLGIGDRHLNNFMVAMETGSVIGIDFGHAFGSATQFLPVPELMPFRLTRQFVSLMLPM 3974
            ::.:..:::|:|||||:|.::.:.:|.::.||:...|... :.|.:||.:|||||:   :|:..|
  Fly  2092 VMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCFEKG-RTLRIPEKVPFRLTQ---NLVQAM 2152

Mouse  3975 KETG------LMCTVMVHALRAFRSCAGLLTDTMEIFVKEPSFDWKSFE--QTMLRKGGSWIQE 4030
            ..||      |.|..::..:|..|..  ||| .:|.||.:|..||.:.:  |.:.|...:.:||
  Fly  2153 GITGIEGPFRLGCEYVLKVMRKERET--LLT-LLEAFVYDPLVDWTTNDDAQALRRSLNAKLQE 2213

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PrkdcNP_035289.2 HEAT 1 288..323
HEAT 2 1001..1037
HEAT 3 1050..1086
Interaction with C1D. /evidence=ECO:0000250 1501..1536 5/15 (33%)
Leucine-zipper 1501..1536 5/15 (33%)
TPR 1 1720..1753 8/55 (15%)
ArAE_1_C <1766..1822 CDD:288564 11/75 (15%)
NUC194 1812..2198 CDD:285387 75/455 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2049..2071 4/21 (19%)
KIP-binding. /evidence=ECO:0000250 2432..3213 143/876 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2614..2635 3/20 (15%)
FAT 3024..3470 CDD:280429 72/466 (15%)
PIKKc_DNA-PK 3719..4014 CDD:270716 89/335 (27%)
FATC 4097..4128 CDD:280430
nonCNP_001284967.1 SMG1 571..1140 CDD:292413 138/887 (16%)
Rapamycin_bind 1738..1845 CDD:285924 31/167 (19%)
PIKKc_SMG1 1894..2196 CDD:270714 90/336 (27%)
FATC 3189..3217 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D26975at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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