DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EDNRA and Dop1R1

DIOPT Version :9

Sequence 1:	NP_001948.1	Gene:	EDNRA / 1909	HGNCID:	3179	Length:	427	Species:	Homo sapiens
Sequence 2:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	457	Identity:	101/457 - (22%)
Similarity:	167/457 - (36%)	Gaps:	126/457 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    22 NPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLV-------------LPSNG-------SMH 66
            |....:|...||....|.| .|..:.|...|.|..|.             |.:||       |.:
  Fly    38 NTSSATTIGGNHTSGSTGF-STNSTLLDADHLPLQLTTAKVDLDIEIDIQLLTNGYDGTTLTSFY 101

Human    67 NYCPQQTKITSAFKYINTVIS--------CTIFIVG----------MVGNATLLRIIYQNKCMRN 113
            |    ::..|:|.: ::|::.        .:|.:||          :.||..:...||..:.:|.
  Fly   102 N----ESSWTNASE-MDTIVGEEPEPLSLVSIVVVGIFLSVLIFLSVAGNILVCLAIYTERSLRR 161

Human   114 GPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCA 178
            ..|..:||||:.||....:.:.......|.|.|     .||...|..:..........::|||||
  Fly   162 IGNLFLASLAIADLFVASLVMTFAGVNDLLGYW-----IFGAQFCDTWVAFDVMCSTASILNLCA 221

Human   179 LSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWIL-SFILAIPEAIGFVMVP-----FEYRGEQHK 237
            :|:|||..:....|........|..|.|.:||:| :|:..:|.::| :..|     ||..|:::.
  Fly   222 ISMDRYIHIKDPLRYGRWVTRRVAVITIAAIWLLAAFVSFVPISLG-IHRPDQPLIFEDNGKKYP 285

Human   238 TCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTC---------------------- 280
            ||.|:.|..:......:      .|||  |.|.....|..:.|
  Fly   286 TCALDLTPTYAVVSSCI------SFYF--PCVVMIGIYCRLYCYAQKHVKSIKAVTRPGEVAEKQ 342

Human   281 ---------------EMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFP---LHLSRI 327
                           ::.|....|....:|:|     :.|.||..::.:|.:||.|   ::::..
  Fly   343 RYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDH-----KAAVTVGVIMGVFLICWVPFFCVNITAA 402

Human   328 LKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCC----CC 388
            ..||         |.......::.::|.:    ||..|||.....:|:|::.|:..|..    ||
  Fly   403 FCKT---------CIGGQTFKILTWLGYS----NSAFNPIIYSIFNKEFRDAFKRILTMRNPWCC 454

Human   389 YQ 390
            .|
  Fly   455 AQ 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EDNRA	NP_001948.1	7tmA_ET-AR	81..380	CDD:320641	78/362 (22%)
		TM helix 1	82..108	CDD:320641	8/43 (19%)
		TM helix 2	115..141	CDD:320641	7/25 (28%)
		TM helix 3	158..188	CDD:320641	10/29 (34%)
		TM helix 4	200..220	CDD:320641	7/20 (35%)
		TM helix 5	252..277	CDD:320641	6/24 (25%)
		TM helix 6	299..329	CDD:320641	7/32 (22%)
		TM helix 7	348..373	CDD:320641	6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..427
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	36/136 (26%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	72/317 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910