DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EDNRA and CCHa2-R

DIOPT Version :9

Sequence 1:	NP_001948.1	Gene:	EDNRA / 1909	HGNCID:	3179	Length:	427	Species:	Homo sapiens
Sequence 2:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	390	Identity:	109/390 - (27%)
Similarity:	175/390 - (44%)	Gaps:	96/390 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    81 YINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGR 145
            ||.||:...|||||::||.||:.|.::::.|||.||..|.||||.||:.:::.:|:.........
  Fly    70 YIVTVLYTLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLVILVCVPVATIVYTQES 134

Human   146 WPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPL-------VTA 203
            |||:.|     :|::..|.:..|:|::|..|.|||.:||.|:.:         ||       :|.
  Fly   135 WPFERN-----MCRISEFFKDISIGVSVFTLTALSGERYCAIVN---------PLRKLQTKPLTV 185

Human   204 IEIVSIWILSFILAIPE-------------AIGFVMV----PF---EYRGEQHKTCMLNATSKFM 248
            ...|.||||:.:|.:|.             |.|.:.:    ||   ||             :|||
  Fly   186 FTAVMIWILAILLGMPSVLFSDIKSYPVFTATGNMTIEVCSPFRDPEY-------------AKFM 237

Human   249 EFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEM-LNRRN--GSLRIALSE-HLKQRREVAKTVF 309
            ...:.:       .|:.:||......|.:|...: ::.||  |..:...|. ..:.|..||:.|.
  Fly   238 VAGKAL-------VYYLLPLSIIGALYIMMAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVV 295

Human   310 CLVVIFALCWFPLHLSRI---LKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYF 371
            ..||:|.:|:||.|:..:   ...|...:.|:       |..::..:|...:.:|||:||:|||.
  Fly   296 AFVVVFFICFFPYHVFELWYHFYPTAEEDFDE-------FWNVLRIVGFCTSFLNSCVNPVALYC 353

Human   372 VSKKFKNCFQSCLCCCCYQSK-------------------SLMTSVPMNGT--SIQWKNHDQNNH 415
            ||..|:..|...|||.|.:.:                   |:..|..:.||  :::...|..:||
  Fly   354 VSGVFRQHFNRYLCCICVKRQPHLRQHSTATGMMDNTSVMSMRRSTYVGGTAGNLRASLHRNSNH 418

Human 416 415
Fly 419 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EDNRA	NP_001948.1	7tmA_ET-AR	81..380	CDD:320641	97/332 (29%)
		TM helix 1	82..108	CDD:320641	13/25 (52%)
		TM helix 2	115..141	CDD:320641	10/25 (40%)
		TM helix 3	158..188	CDD:320641	12/29 (41%)
		TM helix 4	200..220	CDD:320641	8/26 (31%)
		TM helix 5	252..277	CDD:320641	4/24 (17%)
		TM helix 6	299..329	CDD:320641	11/32 (34%)
		TM helix 7	348..373	CDD:320641	9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..427		3/10 (30%)
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	97/332 (29%)
		TM helix 1	71..97	CDD:320593	13/25 (52%)
		TM helix 2	104..130	CDD:320593	10/25 (40%)
		TM helix 3	142..172	CDD:320593	12/29 (41%)
		TM helix 4	182..202	CDD:320593	7/19 (37%)
		TM helix 5	234..259	CDD:320593	7/31 (23%)
		TM helix 6	285..315	CDD:320593	11/29 (38%)
		TM helix 7	330..355	CDD:320593	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910