DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prkar2b and Pka-R1

DIOPT Version :9

Sequence 1:	NP_001351336.1	Gene:	Prkar2b / 19088	MGIID:	97760	Length:	416	Species:	Mus musculus
Sequence 2:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster

Alignment Length:	299	Identity:	126/299 - (42%)
Similarity:	178/299 - (59%)	Gaps:	17/299 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse   101 APVINRFTRRASVCAEAYNPDEEEDDAESRI--IHPKTDDQRNRLQEACKDILLFKNLDPEQMSQ 163
            ||.:.   ||..:.||...    |:||.:.:  :.||.....|.|.:|....:||.:||..:.|.
  Fly   173 APPVR---RRGGISAEPVT----EEDATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLDESERSD 230

Mouse   164 VLDAMFEKLVKEGEHVIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNT 228
            :.||||......||::|.|||:||||||||.|..|::|..:    .|......||||||||:|.|
  Fly   231 IFDAMFPVNHIAGENIIQQGDEGDNFYVIDVGEVDVFVNSE----LVTTISEGGSFGELALIYGT 291

Mouse   229 PRAATITATSPGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEVSERLKVVDVIGTK 293
            |||||:.|.:...|||:||.::|||::.:..:||||||.|:..:..|:||:..|||.|.|.:.|.
  Fly   292 PRAATVRAKTDVKLWGIDRDSYRRILMGSTIRKRKMYEEFLSRVSILESLDKWERLTVADSLETC 356

Mouse   294 VYNDGEQIIAQGDLADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCFRGQYFGELALVTNKP 358
            .::|||.|:.||...|.|:|:..|...:..:|   ||..|:.| |:.|.....||||:||:.::|
  Fly   357 SFDDGETIVKQGAAGDDFYIILEGCAVVLQQR---SEQGEDPA-EVGRLGSSDYFGEIALLLDRP 417

Mouse   359 RAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATY 397
            |||:..|.|.:||:.:|...|||:||||.:|:||||..|
  Fly   418 RAATVVARGPLKCVKLDRARFERVLGPCADILKRNITQY 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prkar2b	NP_001351336.1	Dimerization and phosphorylation	1..151		14/51 (27%)
		DD_RIIbeta_PKA	3..43	CDD:213051
		CAP_ED	152..265	CDD:237999	54/112 (48%)
		CAP_ED	274..394	CDD:237999	51/119 (43%)
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	59/129 (46%)
		CAP_ED	219..328	CDD:237999	54/112 (48%)
		Crp	331..>442	CDD:223736	45/114 (39%)
		CAP_ED	337..453	CDD:237999	51/119 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2591
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760