DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prim2 and DNApol-alpha60

DIOPT Version :9

Sequence 1:	NP_032948.1	Gene:	Prim2 / 19076	MGIID:	97758	Length:	505	Species:	Mus musculus
Sequence 2:	NP_652001.2	Gene:	DNApol-alpha60 / 44915	FlyBaseID:	FBgn0259676	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	195/518 - (37%)
Similarity:	305/518 - (58%)	Gaps:	41/518 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MQF--SGRIRKKLRLAGDQRNASYPHSLQFYLQPPTENISLTEFENLAFDRVKLLKAIE-----N 58
            |:|  ..|.|.::::........|||::..|..||||::.:.|||.||.:|::||:.::     |
  Fly     1 MEFGLKKRARHEVKVEVASLETKYPHNVMLYHYPPTEDVHIDEFEELALERLRLLRVLDRASTRN 65

Mouse    59 LGVSYVKGTEQYQSKLEAEIRKLKFSYRENL---------------EDEYEPRRRDHISHFILRL 108
            |.|.    :::::..:.|::.      ||.|               |.:.:.||||::|||||||
  Fly    66 LRVL----SDEWKEIVSADLT------REGLRSYLRLCSTGGSAKHEADIQTRRRDYLSHFILRL 120

Mouse   109 AYCQSEDLRRWFIQQEMDLLRFRFSILPKDKVQSFLKDSHLHFEAISDEEKTLREQDIMASSPSL 173
            |||:||||.|||:.:||:|.|::|:.|...:|:.||:.:......:::.:|...:..:..|:...
  Fly   121 AYCRSEDLARWFVAREMELFRYKFAALSSFEVKQFLEANGFEIHPLTEAQKDEVKDGLYESTVGQ 185

Mouse   174 SGIKLESESVYKVPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRATLSKALALTARSLP 238
            |..|:|....|||||...|||.|||:.:|:.|:|||...|:|:::..:.:..:.:.|......:.
  Fly   186 SVAKIELLDFYKVPFTQVLDLVRGRRCFLKAGYAYVNTHDLVSLVGTKQQDEIEQGLQAAKTMVE 250

Mouse   239 AVQSDERLQPLLNHLSHSYTGQDYSTQKNTGKISLDQIDSLSTKSFPPCMRQLHKALRENHHLRH 303
            .|::|||:...|..|.:||||:||:..::.. :.::.:|.||..|.|.|||..|:.:|.|||::|
  Fly   251 DVEADERISRTLKALHNSYTGRDYTVCRDAA-VPIESLDQLSKTSMPLCMRMCHEHIRANHHIKH 314

Mouse   304 GGRMQYGLFLKGIGLTLEQALQFWKQEFIRGKMDPDKFDKGYSYNIRHSFGKEGKRTDYTPFSCM 368
            .|||||||||||||:.||.:|:||::||.: |||.|||.:.|.|||.|::||:|...:|||:||.
  Fly   315 SGRMQYGLFLKGIGVALEDSLRFWREEFTK-KMDADKFTRSYEYNIYHNYGKKGSMVNYTPYSCA 378

Mouse   369 KIILTNPPGQGDYHGCPFRHSDAELLKQKMQSYKIPASGISQILDLVKGNHYQVACQKYFEMTHN 433
            ||| .:..|.||.||||:::.|...||.|:.||.:.||.|.:::..|...|||:.|.|||::|||
  Fly   379 KII-KDVAGPGDCHGCPYKNMDQGSLKTKLSSYGLSASAIDEVMFFVSRGHYQIGCGKYFQLTHN 442

Mouse   434 --VDDCGFSLNHPNQFFFESQRILTGGKDIKKEISQPETPQHKPSTQKTRDAASALASLDSSL 494
              |:.   |:||||.:|.||| |..|.:..:...|.|...:.:|..:...|.:..:...|..|
  Fly   443 SPVEP---SINHPNNYFEESQ-IAMGNRQKRANGSAPPKARIRPDIKGHGDRSMLMGDDDDEL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prim2	NP_032948.1	PriL_PriS_Eukaryotic	28..451	CDD:143474	177/444 (40%)
		Interacts with PRIM1. /evidence=ECO:0000250\|UniProtKB:P49643	266..503		101/231 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..486		4/22 (18%)
DNApol-alpha60	NP_652001.2	PriL_PriS_Eukaryotic	30..459	CDD:143474	177/444 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850061
Domainoid	1	1.000	255	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E1_COG2219
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H731
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2140
Isobase	1	0.950	-	0	Normalized mean entropy	S1310
OMA	1	1.010	-	-		QHG53502
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005104
OrthoInspector	1	1.000	-	-		oto94480
orthoMCL	1	0.900	-	-		OOG6_102391
Panther	1	1.100	-	-	LDO	PTHR10537
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R981
SonicParanoid	1	1.000	-	-		X3626
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740